{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T16:39:09Z","timestamp":1783701549212,"version":"3.55.0"},"reference-count":10,"publisher":"American Association for the Advancement of Science (AAAS)","funder":[{"name":"National Key Research and Development Program of China","award":["2024YFC2707300"],"award-info":[{"award-number":["2024YFC2707300"]}]},{"name":"National Key Research and Development Program of China","award":["2024YFC3405604"],"award-info":[{"award-number":["2024YFC3405604"]}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82421004"],"award-info":[{"award-number":["82421004"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32370916"],"award-info":[{"award-number":["32370916"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31988101"],"award-info":[{"award-number":["31988101"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82192874"],"award-info":[{"award-number":["82192874"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Shandong Provincial Key Research and Development Program","award":["2024CXPT087"],"award-info":[{"award-number":["2024CXPT087"]}]}],"content-domain":{"domain":["spj.science.org"],"crossmark-restriction":true},"short-container-title":["Research"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:p>Bariatric surgery has emerged as a promising intervention for obese women with polycystic ovary syndrome (PCOS), a condition strongly associated with obesity and anovulatory infertility. While weight management is a key therapeutic strategy, the optimal approach remains uncertain. A recent randomized controlled trial evaluated the impact of bariatric surgery on ovulation rates in obese women with PCOS. However, methodological limitations, including baseline body mass index discrepancies and minimal weight loss in the medical management group, necessitate cautious interpretation of the findings. To further investigate this issue, we conducted a prospective cohort study involving 192 women with PCOS who had undergone bariatric surgery. We assessed 30 reproductive and metabolic parameters at baseline and at 3, 6, and 12 months postoperatively. Most metabolic parameters improved significantly by 3 months postsurgery but plateaued thereafter, with only triglycerides and high-density lipoprotein cholesterol showing continued improvement. Reproductive outcomes demonstrated sustained improvements in ovulatory dysfunction, coinciding with a reduction in luteinizing hormone levels. However, testosterone levels and polycystic ovarian morphology showed limited improvement, while anti-M\u00fcllerian hormone levels remained unchanged. Despite the total weight loss exceeding 30%, further weight reduction did not proportionally enhance outcomes. These findings suggest that while bariatric surgery effectively improves metabolic health and ovulation in PCOS, its long-term hormonal and ovarian effects remain unclear and require further investigation. Head-to-head comparisons with emerging therapies are also urgently needed to refine weight management strategies for this high-risk population.<\/jats:p>","DOI":"10.34133\/research.0664","type":"journal-article","created":{"date-parts":[[2025,3,19]],"date-time":"2025-03-19T17:40:35Z","timestamp":1742406035000},"update-policy":"https:\/\/doi.org\/10.34133\/aaas_crossmark_01","source":"Crossref","is-referenced-by-count":3,"title":["Bariatric Surgery Impact on Women with Polycystic Ovary Syndrome: A Prospective Cohort Study"],"prefix":"10.34133","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0417-051X","authenticated-orcid":false,"given":"Shumin","family":"Li","sequence":"first","affiliation":[{"name":"State Key Laboratory of Reproductive Medicine and Offspring Health, Center for Reproductive Medicine, Institute of Women, Children and Reproductive Health, \rShandong University, Jinan 250012, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Huang","sequence":"additional","affiliation":[{"name":"Division of Bariatric and Metabolic Surgery, Department of General Surgery, \rQilu Hospital of Shandong University, Jinan, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Han","family":"Zhao","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Reproductive Medicine and Offspring Health, Center for Reproductive Medicine, Institute of Women, Children and Reproductive Health, \rShandong University, Jinan 250012, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaozhuang","family":"Liu","sequence":"additional","affiliation":[{"name":"Division of Bariatric and Metabolic Surgery, Department of General Surgery, \rQilu Hospital of Shandong University, Jinan, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7407-9220","authenticated-orcid":true,"given":"Shigang","family":"Zhao","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Reproductive Medicine and Offspring Health, Center for Reproductive Medicine, Institute of Women, Children and Reproductive Health, \rShandong University, Jinan 250012, China."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","published-online":{"date-parts":[[2025,4,9]]},"reference":[{"issue":"10443","key":"e_1_3_2_2_2","doi-asserted-by":"crossref","first-page":"2456","DOI":"10.1016\/S0140-6736(24)00811-0","article-title":"Bariatric surgery in women with PCOS and obesity","volume":"403","author":"Morin-Papunen L","year":"2024","unstructured":"Morin-Papunen L. Bariatric surgery in women with PCOS and obesity. Lancet. 2024;403(10443):2456\u20132457.","journal-title":"Lancet"},{"key":"e_1_3_2_3_2","article-title":"4,4-Dimethylsterols reduces fat accumulation via inhibiting fatty acid amide hydrolase in\u00a0vitro and in\u00a0vivo","volume":"7","author":"Wang Z","year":"2024","unstructured":"Wang Z, Guo X, Liu R, Jin Q, Chang M, Wang X. 4,4-Dimethylsterols reduces fat accumulation via inhibiting fatty acid amide hydrolase in\u00a0vitro and in\u00a0vivo. Research. 2024;7: Article 0377.","journal-title":"Research"},{"key":"e_1_3_2_4_2","doi-asserted-by":"crossref","DOI":"10.34133\/research.0363","article-title":"Remodeling intestinal microbiota alleviates severe combined hyperlipidemia-induced nonalcoholic steatohepatitis and atherosclerosis in LDLR-\/- hamsters","volume":"7","author":"Miao G","year":"2024","unstructured":"Miao G, Guo J, Zhang W, Lai P, Yitong X, Chen J, Zhang L, Zhou Z, Han Y, Chen G, et al. Remodeling intestinal microbiota alleviates severe combined hyperlipidemia-induced nonalcoholic steatohepatitis and atherosclerosis in LDLR-\/- hamsters. Research. 2024;7: Article 0363.","journal-title":"Research"},{"issue":"2","key":"e_1_3_2_5_2","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pmed.1003679","article-title":"Obesity and risk of female reproductive conditions: A Mendelian randomisation study","volume":"19","author":"Venkatesh SS","year":"2022","unstructured":"Venkatesh SS, Ferreira T, Benonisdottir S, Rahmioglu N, Becker CM, Granne I, Zondervan KT, Holmes MV, Lindgren CM, Wittemans LBL. Obesity and risk of female reproductive conditions: A Mendelian randomisation study. PLOS Med. 2022;19(2): Article e1003679.","journal-title":"PLOS Med"},{"issue":"10443","key":"e_1_3_2_6_2","doi-asserted-by":"crossref","first-page":"2489","DOI":"10.1016\/S0140-6736(24)00538-5","article-title":"Bariatric surgery for spontaneous ovulation in women living with polycystic ovary syndrome: The BAMBINI multicentre, open-label, randomised controlled trial","volume":"403","author":"Samarasinghe SNS","year":"2024","unstructured":"Samarasinghe SNS, Leca B, Alabdulkader S, Dimitriadis GK, Davasgaium A, Thadani P, Parry K, Luli M, O\u2019Donnell K, Johnson B, et al. Bariatric surgery for spontaneous ovulation in women living with polycystic ovary syndrome: The BAMBINI multicentre, open-label, randomised controlled trial. Lancet. 2024;403(10443):2489\u20132503.","journal-title":"Lancet"},{"issue":"1","key":"e_1_3_2_7_2","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1093\/humrep\/deh098","article-title":"Revised 2003 consensus on diagnostic criteria and long-term health risks related to polycystic ovary syndrome (PCOS)","volume":"19","year":"2004","unstructured":"The Rotterdam ESHRE\/ASRM-sponsored PCOS consensus workshop group. Revised 2003 consensus on diagnostic criteria and long-term health risks related to polycystic ovary syndrome (PCOS). Hum Reprod. 2004;19(1):41\u201347.","journal-title":"Hum Reprod"},{"issue":"4","key":"e_1_3_2_8_2","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1016\/j.fertnstert.2023.07.025","article-title":"Recommendations from the 2023 International Evidence-based Guideline for the Assessment and Management of Polycystic Ovary Syndrome","volume":"120","author":"Teede HJ","year":"2023","unstructured":"Teede HJ, Tay CT, Laven J, Dokras A, Moran LJ, Piltonen TT, Costello MF, Boivin J, Redman LM, Boyle JA, et al. Recommendations from the 2023 International Evidence-based Guideline for the Assessment and Management of Polycystic Ovary Syndrome. Fertil Steril. 2023;120(4):767\u2013793.","journal-title":"Fertil Steril"},{"issue":"3","key":"e_1_3_2_9_2","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1093\/humupd\/dmac045","article-title":"Anti-Mullerian hormone for the diagnosis and prediction of menopause: A systematic review","volume":"29","author":"Nelson SM","year":"2023","unstructured":"Nelson SM, Davis SR, Kalantaridou S, Lumsden MA, Panay N, Anderson RA. Anti-Mullerian hormone for the diagnosis and prediction of menopause: A systematic review. Hum Reprod Update. 2023;29(3):327\u2013346.","journal-title":"Hum Reprod Update"},{"issue":"4","key":"e_1_3_2_10_2","doi-asserted-by":"crossref","first-page":"1087","DOI":"10.1002\/hep.23116","article-title":"Importance of changes in adipose tissue insulin resistance to histological response during thiazolidinedione treatment of patients with nonalcoholic steatohepatitis","volume":"50","author":"Gastaldelli A","year":"2009","unstructured":"Gastaldelli A, Harrison SA, Belfort-Aguilar R, Hardies LJ, Balas B, Schenker S, Cusi K. Importance of changes in adipose tissue insulin resistance to histological response during thiazolidinedione treatment of patients with nonalcoholic steatohepatitis. Hepatology. 2009;50(4):1087\u20131093.","journal-title":"Hepatology"},{"issue":"4","key":"e_1_3_2_11_2","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1089\/met.2008.0034","article-title":"The product of fasting glucose and triglycerides as surrogate for identifying insulin resistance in apparently healthy subjects","volume":"6","author":"Simental-Mend\u00eda LE","year":"2008","unstructured":"Simental-Mend\u00eda LE, Rodr\u00edguez-Mor\u00e1n M, Guerrero-Romero F. The product of fasting glucose and triglycerides as surrogate for identifying insulin resistance in apparently healthy subjects. Metab Syndr Relat Disord. 2008;6(4):299\u2013304.","journal-title":"Metab Syndr Relat Disord"}],"container-title":["Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/spj.science.org\/doi\/pdf\/10.34133\/research.0664","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,9]],"date-time":"2025-04-09T08:03:16Z","timestamp":1744185796000},"score":1,"resource":{"primary":{"URL":"https:\/\/spj.science.org\/doi\/10.34133\/research.0664"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1]]},"references-count":10,"alternative-id":["10.34133\/research.0664"],"URL":"https:\/\/doi.org\/10.34133\/research.0664","relation":{},"ISSN":["2639-5274"],"issn-type":[{"value":"2639-5274","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,1]]},"assertion":[{"value":"2025-01-04","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-03-09","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-03-15","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-04-09","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"0664"}}