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Magnetism, as a noninvasive biophysical stimulus, has been employed in the repair of the musculoskeletal system, achieving a series of promising results. In this review, we provide a retrospective analysis and perspective of research on magnetic-driven bone regeneration and functional reconstruction. This review aims to delineate safe and efficient magnetic application modalities and to summarize the potential mechanisms by which magnetism regulates the behavior of skeletal lineage cells, thereby providing insights for the expansion and translational application of magnetic-driven regenerative medicine.<\/jats:p>","DOI":"10.34133\/research.0707","type":"journal-article","created":{"date-parts":[[2025,4,30]],"date-time":"2025-04-30T23:15:08Z","timestamp":1746054908000},"update-policy":"https:\/\/doi.org\/10.34133\/aaas_crossmark_01","source":"Crossref","is-referenced-by-count":9,"title":["Unveiling the Power of Magnetic-Driven Regenerative Medicine: Bone Regeneration and Functional Reconstruction"],"prefix":"10.34133","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-4105-2307","authenticated-orcid":false,"given":"Chenxi","family":"Xu","sequence":"first","affiliation":[{"name":"Pediatric Hospital, Honghui Hospital, \rXi\u2019an Jiaotong University, Xi\u2019an, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1706-7418","authenticated-orcid":false,"given":"Pengzhen","family":"Cheng","sequence":"additional","affiliation":[{"name":"Pediatric Hospital, Honghui Hospital, \rXi\u2019an Jiaotong University, Xi\u2019an, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-3174-5041","authenticated-orcid":false,"given":"Junxiang","family":"Wang","sequence":"additional","affiliation":[{"name":"Pediatric Hospital, Honghui Hospital, \rXi\u2019an Jiaotong University, Xi\u2019an, China."},{"name":"College of Life Sciences, \rNorthwest University, Xi\u2019an, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-0152-7423","authenticated-orcid":false,"given":"Beilei","family":"Zhang","sequence":"additional","affiliation":[{"name":"Office of Medical Information Management, \rThe First Affiliated Hospital of Xi\u2019an Jiaotong University, Xi\u2019an, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peng","family":"Shang","sequence":"additional","affiliation":[{"name":"Key Laboratory for Space Biosciences and Biotechnology, \rNorthwestern Polytechnical University, Xi\u2019an, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3636-6664","authenticated-orcid":true,"given":"Yi","family":"Lv","sequence":"additional","affiliation":[{"name":"Department of Hepatobiliary Surgery, \rThe First Affiliated Hospital of Xi\u2019an Jiaotong University, Xi\u2019an, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3215-2343","authenticated-orcid":true,"given":"Qiang","family":"Jie","sequence":"additional","affiliation":[{"name":"Pediatric Hospital, Honghui Hospital, \rXi\u2019an Jiaotong University, Xi\u2019an, China."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","published-online":{"date-parts":[[2025,5,22]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41584-019-0255-1"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41584-024-01118-4"},{"issue":"3","key":"e_1_3_2_4_2","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1016\/j.tibtech.2019.07.005","article-title":"Using remote fields for complex tissue engineering","volume":"38","author":"Armstrong JPK","year":"2020","unstructured":"Armstrong JPK, Stevens MM. 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