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Decellularized spinal cord (DSC) matrices hold promise due to their native 3-dimensional (3D) structure and extracellular matrix (ECM)-derived biochemical components. However, their limited mechanical properties and insufficient availability of growth factors hinder their effectiveness. To address these limitations, this study introduces a core\u2013shell design that reinforces DSC with a hydrogel-based matrix capable of delivering essential growth factors while preserving its natural structure. By leveraging 3D printing and electrostatic adsorption, the engineered matrix retains the topological features of DSC while introducing new topographical and neurogenic cues. These instructive cues facilitated an 11-fold increase in the number of newly generated neuronal cells, demonstrating lineage-specific neuronal regeneration in\u00a0vivo. Mechanistically, the synergistic effects of ECM-inspired structure and biochemical cues activated the ITGA2\/ITGA11\u2013ERK\/AKT signaling axis and promoted M2 macrophage\/microglia polarization, thereby reducing cavity and scar formation. This optimized microenvironment enhanced endogenous neurogenesis and supported functional recovery after SCI. Overall, this study developed a structure-inspired lineage-specific matrix that effectively stimulates endogenous neuronal regeneration, highlighting its potential for advancing spinal cord repair strategies.<\/jats:p>","DOI":"10.34133\/research.0821","type":"journal-article","created":{"date-parts":[[2025,7,15]],"date-time":"2025-07-15T11:06:22Z","timestamp":1752577582000},"update-policy":"https:\/\/doi.org\/10.34133\/aaas_crossmark_01","source":"Crossref","is-referenced-by-count":6,"title":["Structure-Inspired Lineage-Specific Matrix for Endogenous Neurogenesis in Spinal Cord Injury"],"prefix":"10.34133","volume":"8","author":[{"given":"Bo","family":"Wu","sequence":"first","affiliation":[{"name":"School of Medicine, \rNankai University, Tianjin 300071, China."},{"name":"Department of Orthopedics, General Hospital of Chinese People\u2019s Liberation Army","place":["China"]},{"name":"Department of Orthopaedics, Xinqiao Hospital, \rArmy Military Medical University, Chongqing, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuejiao","family":"Lei","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Southwest Hospital, \rThird Military Medical University (Army Medical University), Chongqing 400038, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xufang","family":"Ru","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Southwest Hospital, \rThird Military Medical University (Army Medical University), Chongqing 400038, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiangling","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics, Southwest Hospital, \rArmy Medical University (Third Military Medical University), Chongqing 400038, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Orthopedics, General Hospital of Chinese People\u2019s Liberation Army","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yibo","family":"Gan","sequence":"additional","affiliation":[{"name":"Department of Spine Surgery, Center of Orthopedics, State Key Laboratory of Trauma and Chemical Poisoning, Daping Hospital, \rArmy Medical University, Chongqing 400042, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Wang","sequence":"additional","affiliation":[{"name":"School of Medicine, \rNankai University, Tianjin 300071, China."},{"name":"Department of Orthopedics, General Hospital of Chinese People\u2019s Liberation Army","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1861-6383","authenticated-orcid":true,"given":"Wenyan","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Southwest Hospital, \rThird Military Medical University (Army Medical University), Chongqing 400038, China."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","published-online":{"date-parts":[[2025,8,7]]},"reference":[{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(14)70144-9"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.1177\/0963689718755778"},{"key":"e_1_3_4_4_2","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2022.113500","article-title":"Spatiotemporal dynamics of the cellular components involved in glial scar formation following spinal cord injury","volume":"153","author":"Zhang C","year":"2022","unstructured":"Zhang C, Kang J, Zhang X, Zhang Y, Huang N, Ning B. 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