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Surface-enhanced Raman scattering (SERS) technology demonstrates strong potential for trace VOC gas detection due to its ultra-high sensitivity and immunity to water interference. However, while surface plasmon resonance (SPR)-free semiconductor substrates offer superior spectral stability and selectivity, their sensitivity toward VOC detection remains suboptimal. This study introduces a novel semiconductor-based SERS substrate composed of copper single atoms anchored on UiO-66 (Cu\n            <jats:sub>1<\/jats:sub>\n            \/UiO-66), achieving a record-low detection limit of 10 parts per billion for VOC gases with a rapid 2-min response time, thereby elevating the gas-sensing performance of SPR-free substrates to unprecedented levels. The exceptional SERS activity originates from the highly delocalized electron properties of single-atomic copper, which effectively facilitates single-atom charge transfer processes. Concurrently, the incorporation of copper single atoms modulates the band structure of UiO-66, substantially enhancing the coupling resonance between the substrate and target molecules. In simulated breath tests mimicking lung cancer patients\u2019 exhalations, Cu\n            <jats:sub>1<\/jats:sub>\n            \/UiO-66 exhibits remarkable VOC recognition capability and robust anti-interference performance. This work pioneers a new paradigm for ultra-sensitive, rapid detection of trace VOCs in exhaled breath, holding substantial promise for early cancer diagnostics and clinical translation.\n          <\/jats:p>","DOI":"10.34133\/research.0841","type":"journal-article","created":{"date-parts":[[2025,7,28]],"date-time":"2025-07-28T12:33:07Z","timestamp":1753705987000},"update-policy":"https:\/\/doi.org\/10.34133\/aaas_crossmark_01","source":"Crossref","is-referenced-by-count":41,"title":["Single-Atom Cu Anchored on a UiO-66 Surface-Enhanced Raman Scattering Sensor for Trace and Rapid Detection of Volatile Organic Compounds"],"prefix":"10.34133","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4629-9872","authenticated-orcid":false,"given":"Yuening","family":"Wang","sequence":"first","affiliation":[{"name":"School of Chemistry, \rBeihang University, Beijing 100191, 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