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This study demonstrates that pectin oligosaccharides synergistically enhance ABX efficacy by restoring gut microbiota balance and selectively enriched antibiotic-resistant\n                    <jats:italic toggle=\"yes\">Parabacteroides goldsteinii<\/jats:italic>\n                    in a colitis mouse model. Our results further indicate that the gavage administration of\n                    <jats:italic toggle=\"yes\">P. goldsteinii<\/jats:italic>\n                    AM58-2XD markedly alleviated colitis via enhancing the branched-chain amino acid metabolic pathway, particularly by facilitating valine metabolism. Notably, these anticolitis effects were partially attenuated in\n                    <jats:italic toggle=\"yes\">P. goldsteinii<\/jats:italic>\n                    <jats:sup>\u0394ilvE<\/jats:sup>\n                    mutants, which are defective in valine-derived isobutyrate (IBN) biosynthesis. We further demonstrated that exogenous IBN supplementation effectively alleviated colitis symptoms in mice and enhanced gut barrier function via activation of the peroxisome proliferator-activated receptor \u03b3 (PPAR\u03b3) pathway. Conditional knockout of PPAR\u03b3 in Caco-2 intestinal epithelial cells markedly abrogated the IBN-induced enhancement of tight junctions, thereby substantiating the critical role of the IBN-PPAR\u03b3 pathway in metabolite-mediated mucosal repair. Collectively, we delineate a prebiotic\/probiotic\u2013metabolite axis wherein\n                    <jats:italic toggle=\"yes\">P. goldsteinii<\/jats:italic>\n                    facilitates mucosal repair via IBN\/PPAR\u03b3-dependent epithelial metabolic reprogramming. This insight redefines antibiotic-resistant commensals as precise biotherapeutics for microbiota restoration in refractory UC management.\n                  <\/jats:p>","DOI":"10.34133\/research.0867","type":"journal-article","created":{"date-parts":[[2025,8,14]],"date-time":"2025-08-14T12:39:36Z","timestamp":1755175176000},"update-policy":"https:\/\/doi.org\/10.34133\/aaas_crossmark_01","source":"Crossref","is-referenced-by-count":15,"title":["Gut Commensal Antibiotic-Resistant\n                    <i>Parabacteroides goldsteinii<\/i>\n                    Ameliorates Mouse Colitis through Valine\u2013Isobutyrate Metabolism"],"prefix":"10.34133","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9453-6911","authenticated-orcid":false,"given":"Ningning","family":"He","sequence":"first","affiliation":[{"name":"School of Basic Medicine, Qingdao Medical College, \rQingdao University, Qingdao 266071, 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