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Currently, the bacterial roles in cancer are particularly emphasized, while the fungal roles are just coming onto the stage. In this Perspective, we mainly focused on the fungi\u2013tumor axis to understand the mycobiome\u2013cancer connection, aiming to answer the questions that cause confusion and impede translational potential: (a) Why should we value the role of mycobiome in oncological research? (b) What will the relationship between fungi and bacteria be in cancer progression? (c) How will the fungi impact cancer? (d) Can we target fungi for development of intervention strategies in anticancer treatment? (e) Will the effort and investment pay back in mycobiome-driven cancer research?<\/jats:p>","DOI":"10.34133\/research.0931","type":"journal-article","created":{"date-parts":[[2025,9,19]],"date-time":"2025-09-19T07:16:52Z","timestamp":1758266212000},"update-policy":"https:\/\/doi.org\/10.34133\/aaas_crossmark_01","source":"Crossref","is-referenced-by-count":8,"title":["Unraveling the Fungi\u2013Cancer Connection"],"prefix":"10.34133","volume":"8","author":[{"given":"Weici","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Thoracic Surgery, The Affiliated Wuxi People\u2019s Hospital of \rNanjing Medical University, Wuxi People\u2019s Hospital, Wuxi Medical Center, Nanjing Medical University, Wuxi 214023, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kai","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery, The Affiliated Wuxi People\u2019s Hospital of \rNanjing Medical University, Wuxi People\u2019s Hospital, Wuxi Medical Center, Nanjing Medical University, Wuxi 214023, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lu","family":"Wang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Systems Medicine for Cancer, Center for Single-Cell Omics, School of Public Health, \rShanghai Jiao Tong University School of Medicine, Shanghai 200025, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ning-Ning","family":"Liu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Systems Medicine for Cancer, Center for Single-Cell Omics, School of Public Health, \rShanghai Jiao Tong University School of Medicine, Shanghai 200025, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4644-9749","authenticated-orcid":true,"given":"Wenjun","family":"Mao","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery, The Affiliated Wuxi People\u2019s Hospital of \rNanjing Medical University, Wuxi People\u2019s Hospital, Wuxi Medical Center, Nanjing Medical University, Wuxi 214023, China."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","published-online":{"date-parts":[[2025,10,3]]},"reference":[{"issue":"1","key":"e_1_3_3_2_2","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1186\/s12943-025-02227-8","article-title":"The mycobiome in human cancer: Analytical challenges, molecular mechanisms, and therapeutic implications","volume":"24","author":"Ding T","year":"2025","unstructured":"Ding T, Liu C, Li Z. 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