{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T18:13:09Z","timestamp":1789582389199,"version":"build-2803163510"},"reference-count":87,"publisher":"American Association for the Advancement of Science (AAAS)","funder":[{"name":"Key R&D Program of Ministry of Science and Technology","award":["2021YFC2702100"],"award-info":[{"award-number":["2021YFC2702100"]}]},{"name":"Key R&D Program of Ministry of Science and Technology","award":["2021YFC2702104"],"award-info":[{"award-number":["2021YFC2702104"]}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82273648"],"award-info":[{"award-number":["82273648"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82171100"],"award-info":[{"award-number":["82171100"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Excellent Academic Leader of Shanghai Science and Technology Commission","award":["22XD1422900"],"award-info":[{"award-number":["22XD1422900"]}]},{"name":"Talent Program of Shanghai Municipal Health and Health Commission","award":["2022XD032"],"award-info":[{"award-number":["2022XD032"]}]}],"content-domain":{"domain":["spj.science.org"],"crossmark-restriction":true},"short-container-title":["Research"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:p>\n                    The excessive elongation of eye axis is a primary contributing factor of myopia, yet the underlying genetic mechanisms remain not fully understood. The study was to explore risk-associated genes of myopia and identified that\n                    <jats:italic toggle=\"yes\">N<\/jats:italic>\n                    -acetyltransferase 2 (NAT2) acted as a regulator in the pathological process of myopia. The genome-wide association study analysis was performed for axial length of eyes in a Chinese population aged 4 to 18 years (\n                    <jats:italic toggle=\"yes\">n<\/jats:italic>\n                    = 6,345), and the most significant locus was 8p22, with\n                    <jats:italic toggle=\"yes\">NAT2<\/jats:italic>\n                    identified as a potential risk-associated gene for myopia. NAT2 was down-regulated by hypoxia in form deprivation-induced murine myopia, and the adeno-associated virus-induced genetic intervention of NAT2 in sclera influenced myopia progression. For mechanism, NAT2 could regulate the phenotypic transition and extracellular matrix remodeling of scleral fibroblasts by maintaining mitochondrial metabolism and inhibiting the ROS\/TGF-\u03b2 pathway, which also had effects on choroidal vascular function. Additionally, administration with \u03b1-ketoglutarate, a downstream metabolite of NAT2, effectively suppressed myopia progression in murine models. These findings highlight NAT2 as a critical regulator of myopia pathogenesis, offering new insights into potential therapeutic strategies targeting mitochondrial metabolism.\n                  <\/jats:p>","DOI":"10.34133\/research.0969","type":"journal-article","created":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T05:04:30Z","timestamp":1760072670000},"update-policy":"https:\/\/doi.org\/10.34133\/aaas_crossmark_01","source":"Crossref","is-referenced-by-count":4,"title":["<i>N<\/i>\n                    -Acetyltransferase 2 Inhibits Myopia by Maintaining Mitochondrial Metabolism in Scleral Fibroblasts"],"prefix":"10.34133","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8496-5288","authenticated-orcid":false,"given":"Wei","family":"Gong","sequence":"first","affiliation":[{"name":"Shanghai Eye Diseases Prevention &amp; Treatment Center\/Shanghai Eye Hospital, School of Medicine, \rTongji University, Shanghai, China."},{"name":"Department of Ophthalmology, Shanghai General Hospital, \rShanghai Jiao Tong University School of Medicine, National Clinical Research Center for Eye Diseases, Center of Eye Shanghai Key Laboratory of Ocular Fundus Diseases, Shanghai Engineering Center for Visual Science and Photomedicine, Shanghai, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhi","family":"Shen","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Renji Hospital, School of Medicine, State Key Laboratory for Oncogenes and Related Genes, Shanghai Cancer Institute, \rShanghai Jiao Tong University, Shanghai, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lingyi","family":"Zhao","sequence":"additional","affiliation":[{"name":"Shanghai Eye Diseases Prevention &amp; 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