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Efficient neutron sources and specific boron carriers are essential for successful treatment. By exploiting the\n                    <jats:sup>10<\/jats:sup>\n                    B(n,\u03b1)\n                    <jats:sup>7<\/jats:sup>\n                    Li nuclear reaction, the BNCT enables precise eradication of\n                    <jats:sup>10<\/jats:sup>\n                    B-loaded tumor malignant cells while sparing adjacent healthy tissues, rendering it particularly advantageous for treating invasive or radioresistant recurrent tumors. Numerous clinical trials related to BNCT have focus on evaluating the safety and efficacy of treating glioblastoma, head and neck carcinoma, meningioma, malignant melanoma, and liver cancer. Preliminary studies have shown that BNCT treatment may extend the overall survival (OS) and improve the quality of life for patients with these cancers. Additionally, the scope of BNCT clinical trials has expanded to other tumor types, such as lung cancer, breast cancer, extramammary Paget\u2019s disease, osteosarcoma, clear cell sarcoma, malignant peripheral nerve sheath tumor, angiosarcoma, thyroid cancer, recurrent chordoma, and gastrointestinal malignancies. This review provides a comprehensive overview of BNCT clinical trials, covering the therapeutic principles of BNCT and the current status and outcomes of clinical trials for various types of tumors. With advancements in neutron beam quality and the development of efficient, specific boron carriers, the therapeutic efficacy of BNCT is expected to be further enhanced, and its scope of application is anticipated to expand. Looking ahead, the BNCT is expected to be integrated with other tumor treatment modalities to augment local tumor control, thereby improving patients\u2019 OS and quality of life.\n                  <\/jats:p>","DOI":"10.34133\/research.0988","type":"journal-article","created":{"date-parts":[[2025,10,24]],"date-time":"2025-10-24T05:22:02Z","timestamp":1761283322000},"update-policy":"https:\/\/doi.org\/10.34133\/aaas_crossmark_01","source":"Crossref","is-referenced-by-count":9,"title":["Advances in Clinical Trials of Boron Neutron Capture Therapy"],"prefix":"10.34133","volume":"9","author":[{"given":"Xiaoling","family":"Li","sequence":"first","affiliation":[{"name":"Cancer Center, Dongguan Engineering Research Center for Innovative Boron Drugs and Novel Radioimmune Drugs, The Tenth Affiliated Hospital, \rSouthern Medical University (Dongguan People\u2019s Hospital), Southern Medical University, Dongguan 523059, China."},{"name":"Guangdong Engineering Research Center of Boron Neutron Therapy and Application in Malignant Tumors, The Tenth Affiliated Hospital, \rSouthern Medical University (Dongguan People\u2019s Hospital), Southern Medical University, Dongguan 523059, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhijie","family":"Liu","sequence":"additional","affiliation":[{"name":"Cancer Center, Dongguan Engineering Research Center for Innovative Boron Drugs and Novel Radioimmune Drugs, The Tenth Affiliated Hospital, \rSouthern Medical University (Dongguan People\u2019s Hospital), Southern Medical University, Dongguan 523059, China."},{"name":"Guangdong Engineering Research Center of Boron Neutron Therapy and Application in Malignant Tumors, The Tenth Affiliated Hospital, \rSouthern Medical University (Dongguan People\u2019s Hospital), Southern Medical University, Dongguan 523059, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kejun","family":"Liu","sequence":"additional","affiliation":[{"name":"Cancer Center, Dongguan Engineering Research Center for Innovative Boron Drugs and Novel Radioimmune Drugs, The Tenth Affiliated Hospital, \rSouthern Medical University (Dongguan People\u2019s Hospital), Southern Medical University, Dongguan 523059, China."},{"name":"Guangdong Engineering Research Center of Boron Neutron Therapy and Application in Malignant Tumors, The Tenth Affiliated Hospital, \rSouthern Medical University (Dongguan People\u2019s Hospital), Southern Medical University, Dongguan 523059, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunhong","family":"Wang","sequence":"additional","affiliation":[{"name":"College of Chemistry and Molecular Engineering, \rPeking University, Beijing 100871, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhigang","family":"Liu","sequence":"additional","affiliation":[{"name":"Cancer Center, Dongguan Engineering Research Center for Innovative Boron Drugs and Novel Radioimmune Drugs, The Tenth Affiliated Hospital, \rSouthern Medical University (Dongguan People\u2019s Hospital), Southern Medical University, Dongguan 523059, China."},{"name":"Guangdong Engineering Research Center of Boron Neutron Therapy and Application in Malignant Tumors, The Tenth Affiliated Hospital, \rSouthern Medical University (Dongguan People\u2019s Hospital), Southern Medical University, Dongguan 523059, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3474-0659","authenticated-orcid":true,"given":"Xiao","family":"Xu","sequence":"additional","affiliation":[{"name":"Cancer Center, Dongguan Engineering Research Center for Innovative Boron Drugs and Novel Radioimmune Drugs, The Tenth Affiliated Hospital, \rSouthern Medical University (Dongguan People\u2019s Hospital), Southern Medical University, Dongguan 523059, China."},{"name":"Guangdong Engineering Research Center of Boron Neutron Therapy and Application in Malignant Tumors, The Tenth Affiliated Hospital, \rSouthern Medical University (Dongguan People\u2019s Hospital), Southern Medical University, Dongguan 523059, China."},{"name":"Department of Diagnostic Radiology, Yong Loo Lin School of Medicine, \rNational University of Singapore, Singapore 119074, Singapore."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","published-online":{"date-parts":[[2026,1,8]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-642-31334-9_1"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM195112062452301"},{"key":"e_1_3_2_4_2","volume-title":"Handbook of boron science.","author":"Hosmane NS","year":"2017","unstructured":"Hosmane NS, Eagling R. 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