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However, actin-targeting agents have faced major translational barriers due to poor specificity and the absence of defined druggable sites. Here, we report a bladder tumor-targeting polyarginine peptide, R11, as a precision modulator of actin dynamics capable of disrupting the cytoskeletal architecture of bladder cancer (BCa) to suppress its lung metastasis potently and persistently. R11 directly interacts with actin, weakening the actin\u2013plectin\u2013vimentin\/integrin \u03b24 axis and initiating a cascade of cytoskeletal disorganization that ultimately impairs cellular motility and metastatic potential. Remarkably, nanoscale multivalent assemblies of R11 amplify these effects through enhanced multivalent binding to actin. This study unveils a new strategy for cytoskeleton-targeted intervention through peptide-based precision materials, highlighting R11 assemblies as a promising therapeutic platform for the treatment of metastatic BCa and potentially other cytoskeleton-dependent malignancies.<\/jats:p>","DOI":"10.34133\/research.1109","type":"journal-article","created":{"date-parts":[[2026,1,5]],"date-time":"2026-01-05T07:17:54Z","timestamp":1767597474000},"update-policy":"https:\/\/doi.org\/10.34133\/aaas_crossmark_01","source":"Crossref","is-referenced-by-count":4,"title":["Polyarginine Peptide R11\u2013Actin Interaction Induces a Domino Effect on Cytoskeleton Remodeling to Suppress Bladder Cancer Metastasis"],"prefix":"10.34133","volume":"9","author":[{"given":"Zhenghong","family":"Liu","sequence":"first","affiliation":[{"name":"Urology and Nephrology Center, Department of Urology, Zhejiang Provincial People\u2019s Hospital, Affiliated People\u2019s Hospital, \rHangzhou Medical College, Hangzhou, 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