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Senescent cells drive chronic inflammation and multitissue dysfunction through the secretion of proinflammatory and profibrotic senescence-associated secretory phenotype cells, making them emerging therapeutic targets. Although first-generation senolytic drugs have entered clinical trials, they face limitations such as insufficient targeting specificity and transient efficacy. The success of chimeric antigen receptor T cell (CAR T cell) therapy in cancer immunotherapy has validated its precision clearance capabilities as a \u201cliving drug\u201d. This review systematically elaborates on the paradigm shift of extending CAR T cell therapy to aging medicine, from the discovery and validation of surface targets on senescent cells to a CAR engineering design tailored to the senescent microenvironment and from evidence of reversing fibrosis and improving metabolic function in preclinical models to the challenges of specificity, safety, and manufacturing faced in clinical translation. Finally, future directions for integrating technologies such as mRNA delivery and artificial intelligence are envisioned in this article, which proposes that CAR T cell therapy may drive the evolution of medicine from \u201ctreating single diseases\u201d to \u201cintervening in shared aging processes\u201d, offering transformative strategies to achieve healthy aging.<\/jats:p>","DOI":"10.34133\/research.1326","type":"journal-article","created":{"date-parts":[[2026,5,25]],"date-time":"2026-05-25T09:08:32Z","timestamp":1779700112000},"update-policy":"https:\/\/doi.org\/10.34133\/aaas_crossmark_01","source":"Crossref","is-referenced-by-count":0,"title":["Chimeric Antigen Receptor T Cells as Living Therapeutics Targeting Senescence and Age-Related Diseases"],"prefix":"10.34133","volume":"9","author":[{"given":"Qingyi","family":"Shao","sequence":"first","affiliation":[{"name":"Department of Laboratory Medicine, Children\u2019s Hospital, \rZhejiang University School of Medicine, National Clinical Research Center for Children and Adolescents\u2019 Health and Diseases, Hangzhou 310052, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danlei","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, Children\u2019s Hospital, \rZhejiang University School of Medicine, National Clinical Research Center for Children and Adolescents\u2019 Health and Diseases, Hangzhou 310052, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenxia","family":"Shao","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, Affiliated Hangzhou First People\u2019s Hospital, School of Medicine, \rWestlake University, Hangzhou 310006, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6756-0630","authenticated-orcid":true,"given":"Qing","family":"Ye","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, Children\u2019s Hospital, \rZhejiang University School of Medicine, National Clinical Research Center for Children and Adolescents\u2019 Health and Diseases, Hangzhou 310052, China."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","published-online":{"date-parts":[[2026,6,12]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1990428"},{"key":"e_1_3_3_3_2","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2026.108131","article-title":"Agrin at the crossroads of aging: A pleiotropic regulator in age-related diseases","volume":"225","author":"Yuan J","year":"2026","unstructured":"Yuan J, Zhang S, Han D, Dong X. 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