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In a recent breakthrough published in\n                    <jats:italic toggle=\"yes\">Cell<\/jats:italic>\n                    , Li et\u00a0al. provide a compelling answer by revealing that peripheral tumors secrete cystatin-C, which binds to preexisting amyloid oligomers and activates triggering receptor expressed on myeloid cells 2 (TREM2) in microglia, leading to the clearance of preexisting amyloid plaques in Alzheimer\u2019s disease mice.\n                  <\/jats:p>","DOI":"10.34133\/research.1456","type":"journal-article","created":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T09:37:34Z","timestamp":1790761054000},"update-policy":"https:\/\/doi.org\/10.34133\/aaas_crossmark_01","source":"Crossref","is-referenced-by-count":0,"title":["Cancer Hacks Neurodegeneration: Cystatin-C as a Bridge for Microglial Amyloid Clearance via TREM2"],"prefix":"10.34133","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-6129-7165","authenticated-orcid":false,"given":"Yuanhao","family":"Zhang","sequence":"first","affiliation":[{"name":"Institute of Precision and Regenerative Medicine, Department of Biomedical Sciences, Division of Biomedical Health Sciences, School of Medicine, \rThe Chinese University of Hong Kong, Shenzhen, Guangdong, China."},{"name":"Division of Clinical Medicine and Health Network, School of Medicine, \rThe Chinese University of Hong Kong, Shenzhen, Guangdong, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7403-8253","authenticated-orcid":true,"given":"Conglei","family":"Li","sequence":"additional","affiliation":[{"name":"Institute of Precision and Regenerative Medicine, Department of Biomedical Sciences, Division of Biomedical Health Sciences, School of Medicine, \rThe Chinese University of Hong Kong, Shenzhen, Guangdong, China."},{"name":"Division of Clinical Medicine and Health Network, School of Medicine, \rThe Chinese University of Hong Kong, Shenzhen, Guangdong, China."},{"name":"Guangdong Basic Research Center of Excellence for Aggregate Science, School of Science and Engineering, \rThe Chinese University of Hong Kong, Shenzhen, Guangdong, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chenzhong","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering, Division of Biomedical Health Sciences, School of Medicine, \rThe Chinese University of Hong Kong, Shenzhen, Guangdong, China."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","published-online":{"date-parts":[[2026,10,14]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41583-021-00533-w"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1079469"},{"key":"e_1_3_2_4_2","doi-asserted-by":"crossref","DOI":"10.34133\/2019\/5341375","article-title":"Promising results from Alzheimer\u2019s disease passive immunotherapy support the development of a preventive vaccine","volume":"2019","author":"Marciani DJ","year":"2019","unstructured":"Marciani DJ. 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