{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,21]],"date-time":"2026-04-21T09:29:01Z","timestamp":1776763741907,"version":"3.51.2"},"reference-count":25,"publisher":"Georg Thieme Verlag KG","issue":"05","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Vet Comp Orthop Traumatol"],"published-print":{"date-parts":[[2011]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>An eight-month-old mixed-breed dog was presented with a history of sudden onset pelvic limb lameness. Radiographic and computed tomographic examinations demonstrated an osteolytic process involving the lumbar spine and pelvis. A comprehensive work-up including serial radiographic skeletal survey, biopsy, routine laboratory investigation and evaluation of parathyroid hormone (PTH) and 25-hydroxy-vitamin D levels failed to reveal any underlying cause for the osteolysis. Conservative treatment using the bisphosphonate drug alendronate and oral analgesic medications resulted in a return to nearly normal long-term function, despite massive lumbar and pelvic osteolysis. The clinical, radiological and histopathological features in this dog are reported, and similarities with the human condition known as Gorham\u2019s disease are discussed.<\/jats:p>","DOI":"10.3415\/vcot-11-03-0047","type":"journal-article","created":{"date-parts":[[2011,8,8]],"date-time":"2011-08-08T07:30:04Z","timestamp":1312788604000},"page":"389-397","source":"Crossref","is-referenced-by-count":2,"title":["Massive osteolysis in a dog resembling Gorham\u2019s disease in humans"],"prefix":"10.3415","volume":"24","author":[{"given":"S.","family":"Lindsay","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V.","family":"Johnson","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"Child","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Farrell","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2017,12,17]]},"reference":[{"key":"10.3415\/VCOT-11-03-0047-1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tripleo.2009.08.043"},{"key":"10.3415\/VCOT-11-03-0047-2","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1056\/NEJM183807110182305","volume":"18","author":"Jackson","year":"1838","journal-title":"Boston Med Surg J"},{"key":"10.3415\/VCOT-11-03-0047-3","doi-asserted-by":"publisher","DOI":"10.3121\/cmr.3.2.65"},{"key":"10.3415\/VCOT-11-03-0047-4","doi-asserted-by":"publisher","DOI":"10.1016\/0030-4220(83)90185-8"},{"key":"10.3415\/VCOT-11-03-0047-5","doi-asserted-by":"publisher","DOI":"10.1016\/j.tripleo.2008.02.028"},{"key":"10.3415\/VCOT-11-03-0047-6","doi-asserted-by":"crossref","unstructured":"Gorham LW, Stout AP. Massive osteolysis (acute spontaneous absorption of bone, phantom bone, disappearing bone): Its relation to hemangiomatosis. J Bone Joint Surg [Am] 1955; 37A: 985-1004.","DOI":"10.2106\/00004623-195537050-00008"},{"key":"10.3415\/VCOT-11-03-0047-7","doi-asserted-by":"crossref","first-page":"62","DOI":"10.5326\/15473317-35-1-62","volume":"35","author":"Hay","year":"1999","journal-title":"J Am Anim Hosp Assoc"},{"key":"10.3415\/VCOT-11-03-0047-8","doi-asserted-by":"publisher","DOI":"10.1354\/vp.42-4-489"},{"key":"10.3415\/VCOT-11-03-0047-9","first-page":"10","volume":"22","author":"Laflamme","year":"1997","journal-title":"Canine Pract"},{"key":"10.3415\/VCOT-11-03-0047-10","unstructured":"Piermattei DL, Johnson KA. Approach to the thoracolumbar vertebrae through a dorsal incision. In: An atlas of surgical approaches to the bones and joints of the dog and cat. 4th ed. Philadelphia: W.B. Saunders Company; 2004. pg. 78-83."},{"key":"10.3415\/VCOT-11-03-0047-11","doi-asserted-by":"publisher","DOI":"10.1016\/S0303-7207(02)00275-7"},{"key":"10.3415\/VCOT-11-03-0047-12","unstructured":"Feldman EC, Nelson RW. Hypercalcaemia and primary hyperparathyroidism. In: Canine and feline endocrinology and reproduction., 3rd ed. Philadelphia: W.B. Saunders Company; 2004. pg. 660-715."},{"key":"10.3415\/VCOT-11-03-0047-13","doi-asserted-by":"publisher","DOI":"10.2460\/javma.234.8.1041"},{"key":"10.3415\/VCOT-11-03-0047-14","doi-asserted-by":"publisher","DOI":"10.1016\/0021-9975(85)90024-6"},{"key":"10.3415\/VCOT-11-03-0047-15","doi-asserted-by":"crossref","unstructured":"LeCouteur RA, Withrow SJ. Tumors of the nervous system. In: Withrow SJ, Vail DM, editors. Small Animal Clinical Oncology. 4th ed. Philadelphia: W.B. Saunders Company; 2007. pg. 659-685.","DOI":"10.1016\/B978-072160558-6.50032-0"},{"key":"10.3415\/VCOT-11-03-0047-16","doi-asserted-by":"publisher","DOI":"10.1007\/s00402-008-0742-3"},{"key":"10.3415\/VCOT-11-03-0047-17","doi-asserted-by":"crossref","unstructured":"Johnson PM, McClure CJ. Observations on massive osteolysis; a review of the literature and report of a case. Radiology 1958; 71: 28-42.","DOI":"10.1148\/71.1.28"},{"key":"10.3415\/VCOT-11-03-0047-18","doi-asserted-by":"publisher","DOI":"10.1007\/s10067-005-1088-7"},{"key":"10.3415\/VCOT-11-03-0047-19","doi-asserted-by":"publisher","DOI":"10.3928\/01477447-20080301-31"},{"key":"10.3415\/VCOT-11-03-0047-20","doi-asserted-by":"publisher","DOI":"10.1620\/tjem.205.187"},{"key":"10.3415\/VCOT-11-03-0047-21","doi-asserted-by":"publisher","DOI":"10.1210\/jc.81.5.1893"},{"key":"10.3415\/VCOT-11-03-0047-22","doi-asserted-by":"publisher","DOI":"10.1002\/path.989"},{"key":"10.3415\/VCOT-11-03-0047-23","first-page":"674","volume":"18","author":"Knoch","year":"1963","journal-title":"Zentralbl Chir"},{"key":"10.3415\/VCOT-11-03-0047-24","doi-asserted-by":"publisher","DOI":"10.1097\/01.mph.0000203721.83566.e6"},{"key":"10.3415\/VCOT-11-03-0047-25","doi-asserted-by":"publisher","DOI":"10.1097\/00007632-198111000-00003"}],"container-title":["Veterinary and Comparative Orthopaedics and Traumatology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.3415\/VCOT-11-03-0047.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,6,13]],"date-time":"2019-06-13T21:47:45Z","timestamp":1560462465000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.3415\/VCOT-11-03-0047"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011]]},"references-count":25,"journal-issue":{"issue":"05","published-online":{"date-parts":[[2017,12,17]]},"published-print":{"date-parts":[[2011]]}},"URL":"https:\/\/doi.org\/10.3415\/vcot-11-03-0047","relation":{},"ISSN":["0932-0814","2567-6911"],"issn-type":[{"value":"0932-0814","type":"print"},{"value":"2567-6911","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011]]}}}