{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,9]],"date-time":"2026-04-09T13:45:55Z","timestamp":1775742355238,"version":"3.50.1"},"reference-count":40,"publisher":"Georg Thieme Verlag KG","issue":"06","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Vet Comp Orthop Traumatol"],"published-print":{"date-parts":[[2015]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Objective: To evaluate whether doxycycline administered to dogs with unilateral cranial cruciate ligament rupture (Uni-CCLR) would decrease the risk of contralateral-CCLR (CoCCLR). To evaluate predictors for Co-CCLR survival. To evaluate if a predisposition of Labrador Retrievers to Co-CCLR exists when compared to other breeds.<\/jats:p><jats:p>Methods: In this prospective randomized controlled clinical trial, 69 client-owned dogs with Uni-CCLR were randomly assigned to a doxycycline (group-D: 7.5 mg\/kg PO BID x 6 weeks) or non-doxycycline (group-ND: negative control). Medical and imaging data, time from Uni- to Co-CCLR and to follow-up were recorded. Statistics included chi-squared test, logistic regression, Kaplan-Meier survival analysis, log rank test, survival curves, and frailty model (p &lt;0.05).<\/jats:p><jats:p>Results: This study included 32 dogs in group-D, and 37 dogs in group-ND. Median follow-up was 54.5 and 61 months, respectively. Contralateral CCLR occurred in 53.1% and 48.6% at medians of 20 and 11 months, respectively. Doxycycline did not significantly decrease the risk of Co-CCLR (p = 0.83). This risk was decreased by 14.2% with each year of age but increased with each increasing kilogram of body weight and each increasing degree of tibial plateau angle by 5.4% and 9.7%, respectively. Labrador Retrievers were not significantly predisposed (p = 0.37).<\/jats:p><jats:p>Clinical significance: At the dose regimen investigated doxycycline does not decrease the risk for Co-CCLR.<\/jats:p>","DOI":"10.3415\/vcot-15-02-0034","type":"journal-article","created":{"date-parts":[[2015,10,1]],"date-time":"2015-10-01T09:51:49Z","timestamp":1443693109000},"page":"371-378","source":"Crossref","is-referenced-by-count":1,"title":["Effect of doxycycline on contra lateral canine cranial cruciate ligament rupture"],"prefix":"10.3415","volume":"28","author":[{"given":"J.","family":"Sung","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Barry","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"Hayashi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. R.","family":"Edwards","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D. J. F.","family":"von Pfeil","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2017,12,23]]},"reference":[{"key":"10.3415\/VCOT-15-02-0034-1","doi-asserted-by":"publisher","DOI":"10.2460\/javma.2005.227.1604"},{"key":"10.3415\/VCOT-15-02-0034-2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1532-950X.2009.00532.x"},{"key":"10.3415\/VCOT-15-02-0034-3","doi-asserted-by":"publisher","DOI":"10.2460\/javma.244.3.328"},{"key":"10.3415\/VCOT-15-02-0034-4","doi-asserted-by":"publisher","DOI":"10.1111\/j.1532-950X.2011.00841.x"},{"key":"10.3415\/VCOT-15-02-0034-5","doi-asserted-by":"publisher","DOI":"10.3415\/VCOT-10-03-0030"},{"key":"10.3415\/VCOT-15-02-0034-6","doi-asserted-by":"publisher","DOI":"10.2460\/javma.232.6.889"},{"key":"10.3415\/VCOT-15-02-0034-7","unstructured":"Hayashi K, Frank JD, Manley PA, et al. Doxycycline treatment for cruciate disease: A clinical trial in 12 dogs. Proceedings of the European College of Veterinary Surgeons 14th Annual Scientific Meeting; 2005 July 7-9; Lyon, France. pg. 444-445"},{"key":"10.3415\/VCOT-15-02-0034-8","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0025331"},{"key":"10.3415\/VCOT-15-02-0034-9","doi-asserted-by":"publisher","DOI":"10.4081\/vsd.2011.e7"},{"key":"10.3415\/VCOT-15-02-0034-10","first-page":"167","volume":"29","author":"Doverspike","year":"1993","journal-title":"J Am Anim Hosp Assoc"},{"key":"10.3415\/VCOT-15-02-0034-11","doi-asserted-by":"publisher","DOI":"10.5326\/0400385"},{"key":"10.3415\/VCOT-15-02-0034-12","doi-asserted-by":"publisher","DOI":"10.2460\/ajvr.2002.63.1279"},{"key":"10.3415\/VCOT-15-02-0034-13","doi-asserted-by":"publisher","DOI":"10.1111\/j.1532-950X.2005.00073.x"},{"key":"10.3415\/VCOT-15-02-0034-14","doi-asserted-by":"publisher","DOI":"10.1111\/j.1532-950X.2010.00675.x"},{"key":"10.3415\/VCOT-15-02-0034-15","doi-asserted-by":"publisher","DOI":"10.2460\/ajvr.2002.63.1423"},{"key":"10.3415\/VCOT-15-02-0034-16","doi-asserted-by":"publisher","DOI":"10.3415\/VCOT-13-06-0082"},{"key":"10.3415\/VCOT-15-02-0034-17","doi-asserted-by":"publisher","DOI":"10.1016\/j.micpath.2006.10.002"},{"key":"10.3415\/VCOT-15-02-0034-18","doi-asserted-by":"crossref","first-page":"814","DOI":"10.1111\/j.1532-950X.2013.12038.x","volume":"42","author":"Bhandal","year":"2013","journal-title":"Vet Surg"},{"key":"10.3415\/VCOT-15-02-0034-19","unstructured":"Boothe DM. Antimicrobial drugs. In: Boothe DM, editor. Small animal clinical pharmacology and therapeutics. 1st edition. Philadelphia, PA: Saunders; 2001. pg. 152-154 and 169-170"},{"key":"10.3415\/VCOT-15-02-0034-20","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780351007"},{"key":"10.3415\/VCOT-15-02-0034-21","doi-asserted-by":"publisher","DOI":"10.1053\/jvet.2001.21399"},{"key":"10.3415\/VCOT-15-02-0034-22","doi-asserted-by":"publisher","DOI":"10.1016\/j.tvjl.2011.10.028"},{"key":"10.3415\/VCOT-15-02-0034-23","unstructured":"Wienke A. Frailty Models in Survival Analysis. Boca Raton: CRC Press, Taylor & Francis Group ISBN: 13: 978-1-4200-7391-1 (eBook - PDF) 2011: 1-299"},{"key":"10.3415\/VCOT-15-02-0034-24","doi-asserted-by":"publisher","DOI":"10.2460\/javma.2005.226.567"},{"key":"10.3415\/VCOT-15-02-0034-25","doi-asserted-by":"crossref","first-page":"811","DOI":"10.2460\/javma.1999.215.06.811","volume":"215","author":"Duval","year":"1999","journal-title":"J Am Vet Med Assoc"},{"key":"10.3415\/VCOT-15-02-0034-26","doi-asserted-by":"crossref","first-page":"1016","DOI":"10.2460\/javma.1993.203.07.1016","volume":"203","author":"Whitehair","year":"1993","journal-title":"J Am Vet Med Assoc"},{"key":"10.3415\/VCOT-15-02-0034-27","unstructured":"Krotscheck U, Nelson S, Mohammed HO. Long Term functional outcome of tibial tuberosity advancement versus tibial plateau leveling osteotomy and extracapsular repair in a heterogeneous population of dogs. American College of Veterinary Surgeons Symposium: The Surgical Summit; 2014 October 16-18; San Diego, CA, USA. Vet Surg 2014; 43: E167-177"},{"key":"10.3415\/VCOT-15-02-0034-28","doi-asserted-by":"crossref","first-page":"1842","DOI":"10.2460\/ajvr.1985.46.09.1842","volume":"46","author":"Vasseur","year":"1985","journal-title":"Am J Vet Res"},{"key":"10.3415\/VCOT-15-02-0034-29","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcpa.2005.06.004"},{"key":"10.3415\/VCOT-15-02-0034-30","doi-asserted-by":"crossref","first-page":"16","DOI":"10.3415\/VCOT-07-08-0078","volume":"22","author":"Inauen","year":"2009","journal-title":"Vet Comp Orthop Traumatol"},{"key":"10.3415\/VCOT-15-02-0034-31","doi-asserted-by":"publisher","DOI":"10.2460\/javma.231.11.1688"},{"key":"10.3415\/VCOT-15-02-0034-32","doi-asserted-by":"publisher","DOI":"10.2460\/javma.2001.218.363"},{"key":"10.3415\/VCOT-15-02-0034-33","doi-asserted-by":"publisher","DOI":"10.2460\/ajvr.2005.66.1563"},{"key":"10.3415\/VCOT-15-02-0034-34","unstructured":"Wikipedia contributors. List of most popular dog breeds [Internet]. Wikipedia, The Free Encyclopedia; 2015 August 8, 08:14 UTC [cited 2015 February 1]. Available from: http:\/\/en.wikipedia.org\/wiki\/List_of_most_popular_dog_breeds"},{"key":"10.3415\/VCOT-15-02-0034-35","doi-asserted-by":"crossref","unstructured":"Chuang C, Ramaker MA, Kaur S, et al. Radiographic risk factors for contralateral rupture in dogs with unilateral cranial cruciate ligament rupture. PLoS One. 2014; 25:e 106389","DOI":"10.1371\/journal.pone.0106389"},{"key":"10.3415\/VCOT-15-02-0034-36","doi-asserted-by":"publisher","DOI":"10.3415\/VCOT-12-12-0148"},{"key":"10.3415\/VCOT-15-02-0034-37","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.0020072"},{"key":"10.3415\/VCOT-15-02-0034-38","doi-asserted-by":"publisher","DOI":"10.1111\/j.1532-950X.2014.12269.x"},{"key":"10.3415\/VCOT-15-02-0034-39","doi-asserted-by":"publisher","DOI":"10.1111\/j.1532-950X.2010.00663.x"},{"key":"10.3415\/VCOT-15-02-0034-40","doi-asserted-by":"publisher","DOI":"10.1111\/vsu.12325"}],"container-title":["Veterinary and Comparative Orthopaedics and Traumatology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.3415\/VCOT-15-02-0034.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,30]],"date-time":"2025-05-30T21:48:55Z","timestamp":1748641735000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.3415\/VCOT-15-02-0034"}},"subtitle":["A prospective randomized clinical trial in 69 dogs"],"short-title":[],"issued":{"date-parts":[[2015]]},"references-count":40,"journal-issue":{"issue":"06","published-online":{"date-parts":[[2017,12,23]]},"published-print":{"date-parts":[[2015]]}},"URL":"https:\/\/doi.org\/10.3415\/vcot-15-02-0034","relation":{},"ISSN":["0932-0814","2567-6911"],"issn-type":[{"value":"0932-0814","type":"print"},{"value":"2567-6911","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015]]}}}