{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,8]],"date-time":"2025-09-08T06:35:17Z","timestamp":1757313317053},"reference-count":16,"publisher":"Georg Thieme Verlag KG","issue":"02","funder":[{"name":"Pet Trust, Ontario Veterinary College"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Vet Comp Orthop Traumatol"],"published-print":{"date-parts":[[2016,3]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Objective: Gentamicin impregnated collagen sponge (GICS) can be used to treat intra-articular surgical site infections. High local concentrations of gentamicin can be reached for short periods; however the collagen vehicle may persist for much longer periods. We wished to determine the effect of sponge implantation on joint inflammation and renal function.<\/jats:p><jats:p>Methods: Eighteen medium sized mixed breed research dogs of hound type were randomized to two groups; arthroscopic implantation of GICS at gentamicin dose = 6 mg\/kg (n = 9) or sham operation (n = 9). Endpoints consisted of joint inflammation measured by synovial fluid cell counts and cytokine concentrations; lameness measured by force plate asymmetry indices; and renal function measured by glomerular filtration rate (GFR) study. The prevalence of lesions associated with aminoglycoside nephrotoxicity was assessed by renal biopsy and transmission electron microscopy.<\/jats:p><jats:p>Results: Gentamicin impregnated collagen sponge implantation caused joint inflammation (p &lt;0.01), lameness (p = 0.04), and decreased GFR (p = 0.04). No difference was observed in the prevalence of renal lesions on biopsy between the treatment and control groups (p = 0.49).<\/jats:p><jats:p>Clinical significance: Gentamicin impregnated collagen sponge implantation causes joint inflammation and lameness as well as GFR reductions at the dose assessed. Gentamicin impregnated collagen sponge are not recommended for intra-articular implantation in dogs.<\/jats:p>","DOI":"10.3415\/vcot-15-05-0088","type":"journal-article","created":{"date-parts":[[2016,2,22]],"date-time":"2016-02-22T12:05:29Z","timestamp":1456142729000},"page":"159-163","source":"Crossref","is-referenced-by-count":8,"title":["Intra-articular implantation of gentamicin impregnated collagen sponge causes joint inflammation and impaired renal function in dogs"],"prefix":"10.3415","volume":"29","author":[{"given":"Tom","family":"Gibson","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Noel","family":"Moens","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephanie","family":"Nykamp","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Darren","family":"Wood","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert","family":"Foster","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Asaf","family":"Lerer","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Galina","family":"Hayes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2017,12,19]]},"reference":[{"key":"10.3415\/VCOT-15-05-0088-1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1000837"},{"key":"10.3415\/VCOT-15-05-0088-2","doi-asserted-by":"crossref","unstructured":"Attmanspacher W, Dittrich V, Sch\u00e4tzler A, et al. 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