{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T21:20:58Z","timestamp":1792099258896,"version":"4.4.0"},"reference-count":9,"publisher":"Maad Rayan Publishing Company","issue":"3","content-domain":{"domain":["ahj.kmu.ac.ir"],"crossmark-restriction":false},"short-container-title":["Addict Health"],"published-print":{"date-parts":[[2024,7,29]]},"abstract":"<jats:p>Background: Naltrexone is a Food and Drug Administration (FDA)-approved anti-craving agent for the long-term treatment of alcohol dependence syndrome (ADS). However, it may not be equally effective in all patients. This study aims to assess naltrexone treatment response over four weeks in a national-level tertiary care setting. Methods: Male patients with ADS (n=100) who were initiated on naltrexone were included in the study. The clinical data, including the drinking pattern and craving, were recorded at baseline. At the end of the one-month follow-up, the drinking status and compliance with naltrexone were recorded. Findings: At the end of one month, more than half of the patients (n=53) were retained in the study. All the treatment-retained patients (n=53) reported naltrexone consumption for more than 24 days in the last month. Those who retained in the study reported significantly less craving among 72% of patients, while an almost 50% reduction in alcohol use was observed. Conclusion: This study adds to the evidence of outcomes with naltrexone in terms of reduced craving and alcohol use. <\/jats:p>","DOI":"10.34172\/ahj.1494","type":"journal-article","created":{"date-parts":[[2024,10,8]],"date-time":"2024-10-08T08:45:46Z","timestamp":1728377146000},"page":"224-227","update-policy":"https:\/\/doi.org\/10.34172\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Naltrexone and its Effects on Craving and Alcohol Use among Patients with Alcohol Dependence Syndroms: A Report"],"prefix":"10.34172","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3923-531X","authenticated-orcid":true,"given":"Ram","family":"Kumar","sequence":"first","affiliation":[{"name":"National Drug Dependence Treatment Centre, Department of Psychiatry, All India Institute of Medical Sciences, Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9759-0542","authenticated-orcid":true,"given":"Rizwana","family":"Quraishi","sequence":"additional","affiliation":[{"name":"National Drug Dependence Treatment Centre, Department of Psychiatry, All India Institute of Medical Sciences, Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3827-1549","authenticated-orcid":true,"given":"Siddharth","family":"Sarkar","sequence":"additional","affiliation":[{"name":"National Drug Dependence Treatment Centre, Department of Psychiatry, All India Institute of Medical Sciences, Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1765-1462","authenticated-orcid":true,"given":"Ravindra","family":"Rao","sequence":"additional","affiliation":[{"name":"National Drug Dependence Treatment Centre, Department of Psychiatry, All India Institute of Medical Sciences, Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1116-7741","authenticated-orcid":true,"given":"Atul","family":"Ambekar","sequence":"additional","affiliation":[{"name":"National Drug Dependence Treatment Centre, Department of Psychiatry, All India Institute of Medical Sciences, Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"20123","published-online":{"date-parts":[[2024,7,29]]},"reference":[{"key":"R1","unstructured":"Ambekar A, Agrawal A, Rao R, Mishra AK, Khandelwal SK, Chadda RK. Magnitude of Substance Use in India. New Delhi: Ministry of Social Justice and Empowerment, Government of India; 2019."},{"key":"R2","doi-asserted-by":"publisher","DOI":"10.4103\/0973-1229.58820"},{"key":"R3","unstructured":"Ambekar A, Kattimani S. Anti-Craving Medications in the Treatment of Alcoholism. Manual for long term pharmacotherapy. National Drug Dependence Treatment Centre, All India Institute of Medical Sciences, developed under WHO, Ministry of Health & Family Welfare, Government of India; 2006."},{"key":"R4","doi-asserted-by":"crossref","unstructured":"R\u00f6sner S, Hackl-Herrwerth A, Leucht S, Vecchi S, Srisurapanont M, Soyka M. Opioid antagonists for alcohol dependence. Cochrane Database Syst Rev. 2010(12):CD001867. doi: 10.1002\/14651858.CD001867.pub3.","DOI":"10.1002\/14651858.CD001867.pub3"},{"key":"R5","doi-asserted-by":"publisher","DOI":"10.1111\/j.1360-0443.2012.04054.x"},{"key":"R6","doi-asserted-by":"publisher","DOI":"10.1093\/alcalc\/36.6.544"},{"key":"R7","doi-asserted-by":"publisher","DOI":"10.1017\/s1461145704004997"},{"key":"R8","doi-asserted-by":"publisher","DOI":"10.1093\/alcalc\/agh104"},{"key":"R9","doi-asserted-by":"publisher","DOI":"10.4103\/ijmr.IJMR_1309_15"}],"container-title":["Addiction and Health"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/ahj.kmu.ac.ir\/article_92509_cfc4bfe2a87b53c54ae0b273ca05331e.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/ahj.kmu.ac.ir\/article_92509_cfc4bfe2a87b53c54ae0b273ca05331e.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,10,17]],"date-time":"2024-10-17T09:32:51Z","timestamp":1729157571000},"score":1,"resource":{"primary":{"URL":"https:\/\/ahj.kmu.ac.ir\/article_92509.html"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,7,29]]},"references-count":9,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2024,7,29]]},"published-print":{"date-parts":[[2024,7,29]]}},"URL":"https:\/\/doi.org\/10.34172\/ahj.1494","relation":{},"ISSN":["2008-4633","2008-8469"],"issn-type":[{"value":"2008-4633","type":"print"},{"value":"2008-8469","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,7,29]]},"assertion":[{"value":"Kerman University of Medical Sciences","name":"journal_owner","label":"Journal Owner"},{"value":"Kerman University of Medical Sciences","name":"journal_publisher","label":"Journal Publisher"},{"value":"2023-07-30","order":1,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-05-01","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-07-29","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}