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Methods: The present study was based on an analytical cross-sectional design and conducted on 310 medical students selected by stratified sampling at Guilan University of Medical Sciences in 2021. The Interpersonal Dependency Inventory and the Iranian Addiction Potential Scale were employed to assess the two variables of interpersonal dependence and the tendency to use substances\/drugs. Findings: The correlation matrix shows that the tendency to use substances\/drugs has a significant negative correlation with interpersonal dependence (P=0.0001, r=-0.285) in general and emotional reliance on another person (P=-0.0001, r=-0.264) and lack of social self-confidence (LSSC) (P=0.0001, r=-0.297) in particular. Female (F=8.57, P=0.004) and married (F=5.14, P=0.024) students showed more tendency to use substances\/drugs than male and single students, but no significant difference was observed regarding interpersonal dependence. Academic course, residence status, parents\u2019 occupation, number of family members, and birth order did not significantly affect the scores. Conclusion: Interpersonal dependence can have different functions, depending on its level. Although interpersonal dependence at maladaptive levels can act as a risk factor and make a person vulnerable to some behavioral problems, at adaptive levels, it acts as a protective factor and reduces those problems.<\/jats:p>","DOI":"10.34172\/ahj.1501","type":"journal-article","created":{"date-parts":[[2024,10,8]],"date-time":"2024-10-08T08:42:54Z","timestamp":1728376974000},"page":"188-197","update-policy":"https:\/\/doi.org\/10.34172\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The Tendency to Use Substances\/Drugs and its Association with Interpersonal Dependence in Iranian Medical Students"],"prefix":"10.34172","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8824-4629","authenticated-orcid":true,"given":"Mohammadrasoul","family":"Khalkhali","sequence":"first","affiliation":[{"name":"Kavosh Cognitive Behavior Sciences and Addiction Research Center, Department of Psychiatry, School of Medicine, Guilan University of Medical Sciences, 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