{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,22]],"date-time":"2025-02-22T00:45:24Z","timestamp":1740185124545,"version":"3.37.3"},"reference-count":41,"publisher":"Maad Rayan Publishing Company","issue":"3","content-domain":{"domain":["ahj.kmu.ac.ir"],"crossmark-restriction":false},"short-container-title":["Addict Health"],"published-print":{"date-parts":[[2024,7,29]]},"abstract":"<jats:p>Background: Disulfiram is the first Food and Drug Administration (FDA)-approved drug for the treatment of alcohol dependence, primarily acting as a deterrent agent. The available literature on disulfiram treatment for alcohol dependence among individuals in low-income and middle-income countries is scarce, while numerous factors impact the acceptance and adherence to such treatment. Methods: The study utilized a purposive sampling methodology. The participants were contacted by telephone at 4 weeks, 12 weeks, and 24 weeks after the initiation of disulfiram treatment. Alcohol abstinence was calculated using the self-reported total alcohol-free days, and adherence and attitudes toward disulfiram treatment were measured using the Treatment Compliance Assessment Scale (TCAS). Findings: The participants had a mean age of 39.30\u00b17.7 years. Nearly 62% and 46% of the subjects reported maintenance of alcohol abstinence after initiation of 12 and 24 weeks of disulfiram treatment, respectively. The proportion of non-adherent subjects increased from 36.3% to 57.2% during the 12-week and 24-week follow-up periods. Attitudes toward disulfiram treatment varied significantly across different time points. A strong positive correlation was observed in the alcohol abstinence, adherence, and attitude scores at different time points (P&lt;0.01). Conclusion: The present study\u2019s findings unveiled that nearly 60% and 40% of the study subjects were maintaining alcohol abstinence and adherence at 12 weeks and 24 weeks after initiation of disulfiram treatment, respectively. Disulfiram could be a viable psychological tool for alcohol abstinence, but objective measurements are required to underpin its utility in this setting.<\/jats:p>","DOI":"10.34172\/ahj.1537","type":"journal-article","created":{"date-parts":[[2024,10,8]],"date-time":"2024-10-08T08:42:14Z","timestamp":1728376934000},"page":"152-158","update-policy":"https:\/\/doi.org\/10.34172\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Alcohol Abstinence, Adherence, and Attitudes toward Disulfiram Treatment for Alcohol Dependence among Patients Attending a Tertiary Care Setting in North India"],"prefix":"10.34172","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6628-2165","authenticated-orcid":true,"given":"Jaison","family":"Joseph","sequence":"first","affiliation":[{"name":"College of Nursing, AIIMS, Bibinagar, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9118-1457","authenticated-orcid":true,"given":"Deepika C.","family":"Khakha","sequence":"additional","affiliation":[{"name":"Nursing Advisor, Dte.GHS , Ministry of Health and Family Welfare, New Delhi, India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"20123","published-online":{"date-parts":[[2024,7,29]]},"reference":[{"key":"R1","doi-asserted-by":"crossref","unstructured":"Robinson SJ, Kenyon AJ. 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