{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T11:44:03Z","timestamp":1792064643377,"version":"4.4.0"},"reference-count":41,"publisher":"Maad Rayan Publishing Company","content-domain":{"domain":["ahj.kmu.ac.ir"],"crossmark-restriction":false},"short-container-title":["Addict Health"],"published-print":{"date-parts":[[2026,5,13]]},"abstract":"<jats:p>Introduction: Methadone poisoning, involving both syrup and tablet formulations, represents a significant public health concern, particularly in regions where methadone is widely utilized for opioid substitution therapy. Methadone accounted for approximately 16% of pediatric acute poisonings and was the leading cause of drug-related deaths in 2023. This study provides a decade-long retrospective analysis of methadone poisoning cases in Kerman, Iran, with a focus on demographic patterns, clinical outcomes, and risk factors to guide prevention and treatment strategies. Methods: This retrospective cross-sectional study reviewed medical records of 5,826 methadone poisoning cases, primarily acute but including some chronic cases, admitted to Afzalipour Hospital between 2013 and 2023. Data on demographics, clinical presentations, comorbidities, and outcomes were analyzed using SPSS version 22, with statistical significance set at P&lt;0.05. Results: The majority of patients were male (63.5%), with the highest prevalence among individuals aged 19\u201340 years (45.3%). Notably, 17.7% of cases involved children under six years old, primarily due to accidental ingestion linked to unsafe storage practices. Intentional poisoning accounted for 80.2% of cases, underscoring the role of mental health and socio-economic factors. Co-intoxication with benzodiazepines (9.8%) and alcohol (4.9%) exacerbated toxicity, while 8.8% of cases coincided with COVID-19 infection, compounding respiratory complications. The mortality rate was low at 1.9% (95% CI: 1.6\u20132.2%), with 63.8% of cases achieving full recovery; and notably, 17.7% of cases involved were children aged under six years old. Conclusion: The findings, including high co-intoxication risks with benzodiazepines (9.8%) and alcohol (4.9%), highlight the urgent need for targeted interventions, including stricter regulation of methadone distribution, childproof packaging, and public education campaigns to reduce accidental pediatric poisonings. Integrated mental health services are critical to addressing intentional poisoning cases (80.2%), while healthcare providers should remain vigilant about polysubstance use. These strategies can significantly reduce methadone-related morbidity and mortality, especially among vulnerable populations such as children and young adults.<\/jats:p>","DOI":"10.34172\/ahj.1678","type":"journal-article","created":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T10:44:21Z","timestamp":1792061061000},"page":"1678","update-policy":"https:\/\/doi.org\/10.34172\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["A Retrospective Cross-Sectional Study on Methadone Poisoning: A Decade of Insights from Kerman, Iran"],"prefix":"10.34172","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9974-4007","authenticated-orcid":true,"given":"Motahareh","family":"Soltani","sequence":"first","affiliation":[{"name":"Pistachio Safety Research Center, Rafsanjan University of Medical Sciences, Rafsanjan, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad Mahdi","family":"Ghanbari","sequence":"additional","affiliation":[{"name":"Pharmaceutics Research Center, Institute of Neuropharmacology, Kerman University of Medical Sciences, Kerman, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6256-6550","authenticated-orcid":true,"given":"Somayyeh","family":"Karami-Mohajeri","sequence":"additional","affiliation":[{"name":"Medicine and Religious Research Center, Kerman University of Medical Sciences, Kerman, Iran"},{"name":"Pharmaceutics Research Center, Institute of Neuropharmacology, Kerman University of Medical Sciences, Kerman, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7269-4919","authenticated-orcid":true,"given":"Zohreh","family":"Oghabian","sequence":"additional","affiliation":[{"name":"Gastroenterology and Hepatology Research Center, Kerman University of Medical Sciences, Kerman, Iran"},{"name":"Department of Toxicology and Pharmacology, Faculty of Pharmacy, Kerman University of Medical Sciences, Kerman, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-5318-6595","authenticated-orcid":true,"given":"Mohammed","family":"Mahdi-Abdulameer","sequence":"additional","affiliation":[{"name":"Iraqi syndicate of pharmacists, Baghdad, Iraq"},{"name":"Department of Toxicology and Pharmacology, Faculty of Pharmacy, Kerman University of Medical Sciences, Kerman, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1550-6031","authenticated-orcid":true,"given":"Maryam","family":"Dalili","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, School of Medicine, Kerman University of Medical Sciences, Kerman, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3539-8982","authenticated-orcid":true,"given":"Soudeh","family":"Khanamani Falahati-Pour","sequence":"additional","affiliation":[{"name":"Pistachio Safety Research Center, Rafsanjan University of Medical Sciences, Rafsanjan, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"20123","published-online":{"date-parts":[[2026,5,13]]},"reference":[{"key":"R1","first-page":"40","article-title":"Pharmacological comprehensive overview of methadone from structure to clinical applications and its abuse with toxicity","volume":"2","author":"Abrar A","year":"2024","journal-title":"Forensic Insights and Health Sciences Bulletin"},{"key":"R2","doi-asserted-by":"publisher","DOI":"10.5055\/jom.0897"},{"key":"R3","unstructured":"Eide D, Muller A, Bukten A, Clausen T. 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