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Findings: The results of the study showed that DAT mRNA expression was not statistically significant in the affected subjects compared to the control group. Regarding DRD2, mRNA expression was increased significantly in the MM subjects compared to the control group (P=0.002). Conclusion: Our study could guide further research to refine the clinical applicability of biomarkers related to dopamine signaling proteins in opioid addiction.<\/jats:p>","DOI":"10.34172\/ahj.1714","type":"journal-article","created":{"date-parts":[[2026,8,6]],"date-time":"2026-08-06T08:19:40Z","timestamp":1786004380000},"page":"1714","update-policy":"https:\/\/doi.org\/10.34172\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Dopamine D2 Receptor and Dopamine Transporter mRNA Expression in Addicted Peripheral Blood Lymphocytes"],"prefix":"10.34172","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-4060-811X","authenticated-orcid":true,"given":"Nasrin","family":"Hamedanian","sequence":"first","affiliation":[{"name":"Student Research Committee, Qom University of Medical Sciences, Qom, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2406-5963","authenticated-orcid":true,"given":"Morteza","family":"Karimipoor","sequence":"additional","affiliation":[{"name":"Molecular Medicine Department, Biotechnology Research Center, Pasteur Institute of Iran, Tehran, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3761-4711","authenticated-orcid":true,"given":"Meysam","family":"Amidfar","sequence":"additional","affiliation":[{"name":"Isfahan University of Medical Sciences, Isfahan, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9033-9144","authenticated-orcid":true,"given":"Sadegh","family":"Yoosefee","sequence":"additional","affiliation":[{"name":"Neurosciences Research Center, Qom University of Medical Sciences, Qom, Iran"},{"name":"Spiritual Health Research Center, Qom University of Medical Sciences, Qom, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"20123","published-online":{"date-parts":[[2026,3,9]]},"reference":[{"key":"R1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2013.07.064"},{"key":"R2","doi-asserted-by":"publisher","DOI":"10.1385\/nmm:5:1:085"},{"key":"R3","doi-asserted-by":"publisher","DOI":"10.1016\/j.metrad.2023.100008"},{"key":"R4","doi-asserted-by":"publisher","DOI":"10.1038\/sj.mp.4001507"},{"key":"R5","doi-asserted-by":"publisher","DOI":"10.1152\/jn.1998.80.1.1"},{"key":"R6","doi-asserted-by":"publisher","DOI":"10.1046\/j.1471-4159.2002.00820.x"},{"key":"R7","doi-asserted-by":"publisher","DOI":"10.1016\/s0165-5728(01)00317-4"},{"key":"R8","doi-asserted-by":"publisher","DOI":"10.1111\/ahg.12322"},{"key":"R9","doi-asserted-by":"publisher","DOI":"10.1007\/s00406-023-01626-6"},{"key":"R10","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneumeth.2008.07.018"},{"key":"R11","doi-asserted-by":"publisher","DOI":"10.1016\/s0165-5728(02)00280-1"},{"key":"R12","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2009.04.060"},{"key":"R13","doi-asserted-by":"publisher","DOI":"10.2174\/157015911795596612"},{"key":"R14","doi-asserted-by":"publisher","DOI":"10.2217\/bmm-2021-0291"},{"key":"R15","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2017.01.012"},{"key":"R16","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0075259"},{"key":"R17","doi-asserted-by":"crossref","unstructured":"American Psychiatric Association (APA). 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