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Methods: A quantitative review of the literature searched in PubMed and Google Scholar databases yielded a total of 1416 studies among which 27 cross-sectional studies, conducted on the general population of 15 and above years of age, were selected based on the eligibility criteria. Findings: A sample of 1,021,118 individuals were investigated in this study. The most commonly used substances were marijuana (100%), methadone (69.86%), and large cigar (60%). A total of 26 substances were reported to have been used during pandemic, 13 of which showed trends in usage (increased\/decreased\/no change). Of the total sample, 45.89% were males, 54.14% females, and 1.28% others. Conclusion: Everyone and anyone is susceptible to alcohol, tobacco, and other substance use and abuse at different stages of their lives. Therefore, the need for effective preventive strategies is critical in community efforts to combat substance abuse. Combined efforts from local and global stakeholders will lead to curbing the issue of substance use and abuse worldwide. <\/jats:p>","DOI":"10.34172\/ahj.2022.1274","type":"journal-article","created":{"date-parts":[[2023,2,19]],"date-time":"2023-02-19T18:55:18Z","timestamp":1676832918000},"page":"296-308","update-policy":"https:\/\/doi.org\/10.34172\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Trends in Substance Use and Abuse During COVID-19 Among the General Population"],"prefix":"10.34172","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3599-3132","authenticated-orcid":true,"given":"Rajashree","family":"Shankar","sequence":"first","affiliation":[{"name":"Department of Public Health, The National Institute of Health and Family Welfare, Baba Gang Nath Marg, New Delhi, 110064, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vandana","family":"Bhattacharya","sequence":"additional","affiliation":[{"name":"Department of Public Health, The National Institute of Health and Family Welfare, Baba Gang Nath Marg, New Delhi, 110064, India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"20123","published-online":{"date-parts":[[2022,10,29]]},"reference":[{"key":"R1","doi-asserted-by":"publisher","DOI":"10.7326\/m20-1212"},{"key":"R2","unstructured":"Substance Use, Abuse and Dependence. 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