{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,2]],"date-time":"2026-11-02T20:19:08Z","timestamp":1793650748678,"version":"4.5.1"},"reference-count":48,"publisher":"Maad Rayan Publishing Company","issue":"3","content-domain":{"domain":["ahj.kmu.ac.ir"],"crossmark-restriction":false},"short-container-title":["Addict Health"],"published-print":{"date-parts":[[2023,7,29]]},"abstract":"<jats:p>Background: Morphine is a narcotic pain reliever that is prescribed to reduce postoperative pain and can produce reactive oxygen species (ROS). Therefore, it can have negative effects on spermatogenesis and male fertility. Vitamin E is an effective antioxidant which plays an important role in membrane lipid peroxidation due to increased ROS. The present study aimed to evaluate the effects of vitamin E and morphine on sperm parameters, level of malondialdehyde (MDA), and diameter of seminiferous tubules in morphine-treated mice. Methods: In this experimental study, 80 mice were divided into ten groups (n=8) including control, normal saline, vehicle, morphine, various doses of vitamin E (100, 200, 300 mg\/kg), and morphine plus vitamin E (100, 200, 300 mg\/kg) groups. The groups were followed up for 30 consecutive days. Sperm parameters, testis weight, the diameter of seminiferous tubules, and the level of MDA were analyzed and compared. Findings: Data analysis showed seminal parameters decreased significantly (excluding sperm count) and there was an increase in the level of MDA in morphine-treated mice compared with the normal saline group (P&lt;0.05). Administration of E100 to morphinetreated mice did not show a significant difference in the evaluated parameters compared with the morphine group. However, E200 and E300 significantly reduced MDA and improved sperm parameters (P\u22640.05). Conclusion: The results showed co-administration of vitamin E in high doses (200 &amp; 300) could prevent the deleterious effects of morphine on some reproductive parameters and decrease the level of MDA in morphine-treated mice.<\/jats:p>","DOI":"10.34172\/ahj.2023.1415","type":"journal-article","created":{"date-parts":[[2023,10,14]],"date-time":"2023-10-14T09:16:35Z","timestamp":1697274995000},"page":"177-184","update-policy":"https:\/\/doi.org\/10.34172\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Evaluation of the Effect of Vitamin E on Reproductive Parameters in Morphine-Treated Male Mice"],"prefix":"10.34172","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-5951-3307","authenticated-orcid":true,"given":"Katayoon","family":"Arjmand","sequence":"first","affiliation":[{"name":"Masters student, Department of Anatomical Sciences, Faculty of Medicine, Kurdistan University of Medical Sciences, Sanandaj, 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