{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T04:56:50Z","timestamp":1762145810153,"version":"3.37.3"},"reference-count":38,"publisher":"Maad Rayan Publishing Company","issue":"4","content-domain":{"domain":["ahj.kmu.ac.ir"],"crossmark-restriction":false},"short-container-title":["Addict Health"],"published-print":{"date-parts":[[2023,10,29]]},"abstract":"<jats:p>Background: This study aimed to assess the association of sleep apnea syndrome (SAS) with methadone dose and timing of administration in patients receiving methadone maintenance treatment (MMT) for opioid use disorder (OUD). Methods: This retrospective cross-sectional study was conducted on adult patients receiving MMT who had a nocturnal respiratory polygraphy between November 2015 and December 2021. Data on methadone treatment and polygraph recording, including the apnea-hypopnea index (AHI) were collected. Findings: A total of 40 patients, mostly male (72.5%), with a mean age of 35\u00b16.7 years and a mean body mass index (BMI) of 25.1\u00b14.5 kg\/m\u00b2 were included. The daily dose of methadone was significantly associated with an AHI\u226515 events\/h as well as an AHI\u226530 events\/h, even after adjustment for age, gender, BMI, and benzodiazepine use. However, these associations were not preserved when the time of administration (day vs evening) was considered, while the evening administration was significantly associated with an AHI\u226515 events\/h. The best sensitivity and specificity for the prediction of AHI\u226515 events\/h and AHI\u226530 events\/h were obtained with daily methadone doses of\u226572.5 mg and 77.5 mg, respectively. Conclusion: In this sample of MMT patients, methadone doses of 72.5 mg and 77.5 mg were the best cut-off values for predicting AHI\u226515 and\u226530 events\/h, respectively, especially when taken in the evening. These results should draw clinicians\u2019 attention to the importance of SAS screening, and further studies are needed, notably comparisons with buprenorphine.<\/jats:p>","DOI":"10.34172\/ahj.2023.1455","type":"journal-article","created":{"date-parts":[[2024,1,22]],"date-time":"2024-01-22T12:01:57Z","timestamp":1705924917000},"page":"240-246","update-policy":"https:\/\/doi.org\/10.34172\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Methadone Dose and Timing of Administration as Predictors of Sleep Apnea Syndrome During Methadone Maintenance Treatment: A Retrospective Cross-sectional Study"],"prefix":"10.34172","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-4467-1373","authenticated-orcid":true,"given":"Cl\u00e9ment","family":"Guillet","sequence":"first","affiliation":[{"name":"Sleep Exploration Centre, La Chartreuse Psychiatric Hospital, 21000 Dijon, France"},{"name":"Depression Unit, La Chartreuse Psychiatric Hospital, 21000 Dijon, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7023-1953","authenticated-orcid":true,"given":"Francky Teddy","family":"Endomba","sequence":"additional","affiliation":[{"name":"Medical Mind Association, Yaound\u00e9, Cameroon"},{"name":"Sleep Specialized Transversal Training, Psychiatry Internship Program, University of Burgundy, 21000 Dijon, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Aravantinos","sequence":"additional","affiliation":[{"name":"Sleep Exploration Centre, La Chartreuse Psychiatric Hospital, 21000 Dijon, France"},{"name":"Addictology Unit, La Chartreuse Psychiatric Hospital, 21000 Dijon, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aymard","family":"Hussami","sequence":"additional","affiliation":[{"name":"Sleep Exploration Centre, La Chartreuse Psychiatric Hospital, 21000 Dijon, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Florence","family":"Beye","sequence":"additional","affiliation":[{"name":"Pharmacy Unit, La Chartreuse Psychiatric Hospital, 21000 Dijon, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean Claude","family":"Girod","sequence":"additional","affiliation":[{"name":"Sleep Exploration Centre, La Chartreuse Psychiatric Hospital, 21000 Dijon, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7590-8644","authenticated-orcid":true,"given":"Ludwig Serge Aho","family":"Gl\u00e9l\u00e9","sequence":"additional","affiliation":[{"name":"Service D\u2019\u00e9pid\u00e9miologie Et D\u2019hygi\u00e8ne Hospitali\u00e8re, CHU H\u00f4pital D\u2019enfants, 14 Rue Paul 10 Gaffarel, 21079, Dijon, France"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"20123","published-online":{"date-parts":[[2023,10,29]]},"reference":[{"key":"R1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMp2210121"},{"key":"R2","doi-asserted-by":"publisher","DOI":"10.7326\/aitc202201180%m35007147"},{"key":"R3","doi-asserted-by":"publisher","DOI":"10.7326\/m20-1141"},{"key":"R4","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2020-037425"},{"key":"R5","doi-asserted-by":"publisher","DOI":"10.1016\/j.sleep.2021.05.021"},{"key":"R6","doi-asserted-by":"publisher","DOI":"10.1111\/ajad.12424"},{"key":"R7","doi-asserted-by":"publisher","DOI":"10.1016\/s0740-5472(03)00191-0"},{"key":"R8","doi-asserted-by":"publisher","DOI":"10.1016\/j.drugalcdep.2005.08.011"},{"key":"R9","doi-asserted-by":"publisher","DOI":"10.1213\/ane.0000000000000672"},{"key":"R10","doi-asserted-by":"publisher","DOI":"10.1111\/dar.13449"},{"key":"R11","doi-asserted-by":"publisher","DOI":"10.5055\/jom.2018.0526"},{"key":"R12","doi-asserted-by":"publisher","DOI":"10.1016\/j.drugalcdep.2009.11.019"},{"key":"R13","doi-asserted-by":"publisher","DOI":"10.1111\/j.1526-4637.2007.00343.x"},{"key":"R14","doi-asserted-by":"publisher","DOI":"10.1016\/j.euroneuro.2009.04.001"},{"key":"R15","doi-asserted-by":"publisher","DOI":"10.5664\/jcsm.6582"},{"key":"R16","doi-asserted-by":"publisher","DOI":"10.5664\/jcsm.2172"},{"key":"R17","doi-asserted-by":"publisher","DOI":"10.5664\/jcsm.6506"},{"key":"R18","doi-asserted-by":"publisher","DOI":"10.1155\/2017\/3762651"},{"key":"R19","doi-asserted-by":"crossref","first-page":"455","DOI":"10.5664\/jcsm.26908","article-title":"Chronic opioid use is a risk factor for the development of central sleep apnea and ataxic breathing","volume":"3","author":"Walker JM","year":"2007","journal-title":"J Clin Sleep Med"},{"key":"R20","doi-asserted-by":"publisher","DOI":"10.1200\/jco.1998.16.10.3216"},{"key":"R21","doi-asserted-by":"crossref","first-page":"536","DOI":"10.5694\/j.1326-5377.2000.tb139323.x","article-title":"The rediscovery of methadone for cancer pain management","volume":"173","author":"Ayonrinde OT","year":"2000","journal-title":"Med J Aust"},{"key":"R22","doi-asserted-by":"publisher","DOI":"10.1200\/jco.2001.19.11.2898"},{"key":"R23","doi-asserted-by":"publisher","DOI":"10.3402\/jchimp.v2i4.19541"},{"key":"R24","doi-asserted-by":"publisher","DOI":"10.1016\/j.smrv.2021.101441"},{"key":"R25","doi-asserted-by":"publisher","DOI":"10.1097\/j.pain.0000000000001906"},{"key":"R26","unstructured":"Roisman G, Rabec C, Escourrou P. Apn\u00e9es et Hypopn\u00e9es Centrales du Sommeil [Internet]. EM-Consulte. Masson E. Available from: https:\/\/www.em-consulte.com\/article\/939011\/apnees-et-hypopnees-centrales-du-sommeil. Accessed December 11, 2022."},{"key":"R27","doi-asserted-by":"publisher","DOI":"10.1113\/jp280214"},{"key":"R28","doi-asserted-by":"publisher","DOI":"10.1213\/ane.0000000000005378"},{"key":"R29","doi-asserted-by":"publisher","DOI":"10.5664\/jcsm.9730"},{"key":"R30","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200810-1658OC"},{"key":"R31","doi-asserted-by":"publisher","DOI":"10.1016\/j.mcna.2010.02.007"},{"key":"R32","first-page":"1048","article-title":"d-Methadone blocks morphine tolerance and N-methyl-D-aspartate-induced hyperalgesia","volume":"289","author":"Davis AM","year":"1999","journal-title":"J Pharmacol Exp Ther"},{"key":"R33","doi-asserted-by":"publisher","DOI":"10.1111\/pme.12910"},{"key":"R34","doi-asserted-by":"publisher","DOI":"10.1002\/cpt1972135part1633"},{"key":"R35","doi-asserted-by":"publisher","DOI":"10.2165\/00003088-200241140-00003"},{"key":"R36","doi-asserted-by":"publisher","DOI":"10.5935\/1806-0013.20150012"},{"key":"R37","doi-asserted-by":"publisher","DOI":"10.5603\/ARM.a2020.0160"},{"key":"R38","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00051315"}],"container-title":["Addiction and Health"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/ahj.kmu.ac.ir\/article_92381_f1006f72e9d99cf62320c3e6c96af0a1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/ahj.kmu.ac.ir\/article_92381_f1006f72e9d99cf62320c3e6c96af0a1.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,22]],"date-time":"2024-01-22T12:02:02Z","timestamp":1705924922000},"score":1,"resource":{"primary":{"URL":"https:\/\/ahj.kmu.ac.ir\/article_92381.html"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,10,29]]},"references-count":38,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2023,10,29]]},"published-print":{"date-parts":[[2023,10,29]]}},"URL":"https:\/\/doi.org\/10.34172\/ahj.2023.1455","relation":{},"ISSN":["2008-4633","2008-8469"],"issn-type":[{"type":"print","value":"2008-4633"},{"type":"electronic","value":"2008-8469"}],"subject":[],"published":{"date-parts":[[2023,10,29]]},"assertion":[{"value":"Kerman University of Medical Sciences","name":"journal_owner","label":"Journal Owner"},{"value":"Kerman University of Medical Sciences","name":"journal_publisher","label":"Journal Publisher"},{"value":"2023-03-22","order":1,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-05-15","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-10-29","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}