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Then, the participants filled out the Relapse Prediction Scale (RPS), Multidimensional Experiential Avoidance Questionnaire (MEAQ), Integrative Self-Knowledge Scale (ISK), and Basic Psychological Needs Scale (BPNS). Data were analyzed using stepwise regression via SPSS software (version 25). Findings: The results of the study demonstrated that some of the components of experiential avoidance including distraction, distress endurance, behavioral avoidance, and distress aversion could account for 14.0% of the variance of the relapse in the addicts (P&lt;0.05). Moreover, the obtained results considering the reflective self-knowledge component and the overall score of integrative self-knowledge could explain 15.0% of the variance in relapse in the addicts. Among the basic psychological needs, communication could predict 3.8% of the variance in relapse. Conclusion: Based on the results of the present study, it is suggested that through addiction treatment and prevention of relapse programs, psychologists reduce drug relapse in addicts by decreasing distractions and behavioral avoidance, increasing distress endurance, enhancing self-knowledge, and improving efficient relationships.<\/jats:p>","DOI":"10.34172\/ahj.2024.1359","type":"journal-article","created":{"date-parts":[[2024,6,29]],"date-time":"2024-06-29T06:47:41Z","timestamp":1719643661000},"page":"69-75","update-policy":"https:\/\/doi.org\/10.34172\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Enhancing Relapse Prevention: Examining the Impact of Experiential Avoidance, Integrative Self-Knowledge, and Basic Psychological Needs in Substance Use Treatment"],"prefix":"10.34172","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7203-9332","authenticated-orcid":true,"given":"Leila","family":"Ayaz","sequence":"first","affiliation":[{"name":"Faculty of Humanities and Arts, Islamic Azad University, Zanjan Branch, Zanjan, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3660-5880","authenticated-orcid":true,"given":"Fatemeh","family":"Nazari","sequence":"additional","affiliation":[{"name":"Department of Psychology, Faculty of Humanities and Arts, Islamic Azad University, Zanjan Branch, Zanjan, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"20123","published-online":{"date-parts":[[2024,5,1]]},"reference":[{"key":"R1","doi-asserted-by":"crossref","unstructured":"American Psychiatric Association (APA). 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