{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,11]],"date-time":"2026-04-11T10:11:40Z","timestamp":1775902300802,"version":"3.50.1"},"reference-count":41,"publisher":"Maad Rayan Publishing Company","issue":"5","content-domain":{"domain":["www.aimjournal.ir"],"crossmark-restriction":false},"short-container-title":["Arch Iran Med"],"abstract":"<jats:p><jats:bold>Background<\/jats:bold>: As there are different views on the effects of aminophylline on neonatal renal function, we intended to observe the effects of aminophylline on renal dysfunction in neonates with prenatal asphyxia.<jats:bold>Methods<\/jats:bold>: This randomized trial was conducted in the Obstetrics and Gynecology Hospital, Tehran, Iran, from June 2016 to May 2017, in neonates with moderate to severe asphyxia during birth. Fifty-six neonates were divided randomly into two groups. The intervention group received one dose of 5mg\/kg slow intravenous aminophylline injection and the placebo group received 2 mL\/kg of intravenous 10% solution of dextrose saline during the first hour of life. They were monitored and compared for renal functional indices, electrolytes, and complications of asphyxia during the three days of life.<jats:bold>Results<\/jats:bold>: The mean of Cr (37.9 \u00b1 8.8 vs 38.5 \u00b1 9.4 and 20.8 \u00b1 4.8 vs 30.1 \u00b1 5.2 \u03bcmol\/L), GFR (21.55 \u00b1 4.7 vs 20.25 \u00b1 4.4 and 30.8 \u00b1 7.1 vs 20.1 \u00b1 6.5 mL\/minute\/1.73 m2 ), Na (135.1 \u00b1 12.4 vs134.5 \u00b1 11.2 and 128.9 \u00b1 11.5 vs 134.2 \u00b1 10.9 mEq\/L), and urine output (98.2 \u00b1 25 vs 96.8 \u00b1 23 and 148.7 \u00b1 35 vs 108.8 \u00b1 20 cc) were in the aminophylline treated and placebo group on the 1st and 3rd days, respectively. The mean difference of Cr (-9.3 (-8.9; -9.7) \u03bcmol\/L); (<jats:italic>P<\/jats:italic>= 0.02), GFR (10.7 (10.1; 11.3) mL\/minute\/1.73 m2 ) (<jats:italic>P<\/jats:italic>= 0.009), Na (-5.3 (-5.9; -4.7) mEq\/L) (<jats:italic>P<\/jats:italic>= 0.002), and urine volume (39.9 (24.9; 54.9) cc) (<jats:italic>P<\/jats:italic>= 0.001) presented statistically significant differences on the third day between the intervention and placebo group.<jats:bold>Conclusion<\/jats:bold>: Aminophylline was effective in preventing renal dysfunction in neonates with asphyxia. Neonates who received aminophylline indicated a significant improvement in GFR and urine output on the first day of life.<\/jats:p>","DOI":"10.34172\/aim.2020.20","type":"journal-article","created":{"date-parts":[[2020,5,8]],"date-time":"2020-05-08T12:57:53Z","timestamp":1588942673000},"page":"312-318","update-policy":"https:\/\/doi.org\/10.34172\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Effect of Aminophylline in Preventing Renal Dysfunction among Neonates with Prenatal Asphyxia: A Clinical Trial"],"prefix":"10.34172","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2146-3752","authenticated-orcid":true,"given":"Maryam","family":"Saboute","sequence":"first","affiliation":[{"name":"Department of Neonatology, Akbar Abadi Hospital, Iran University of Medical Sciences, (IUMS), Tehran, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1588-5169","authenticated-orcid":true,"given":"Javad","family":"Balasi","sequence":"additional","affiliation":[{"name":"Department of Neonatology, Ali Asghar Hospital, Iran University of Medical Sciences, (IUMS), Tehran, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2045-6430","authenticated-orcid":true,"given":"Saleheh","family":"Tajalli","sequence":"additional","affiliation":[{"name":"School of Nursing and Midwifery, Iran University of Medical Sciences, (IUMS), Tehran, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8187-9114","authenticated-orcid":true,"given":"Mahmoud","family":"Hajipour","sequence":"additional","affiliation":[{"name":"Student Research Committee, Epidemiology Department, School of Public Health and Safety, Shahid Beheshti University of Medical Sciences, Tehran, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shaghayegh","family":"Heshmat","sequence":"additional","affiliation":[{"name":"Department of Neonatology, Ali Asghar Hospital, Iran University of Medical Sciences, (IUMS), Tehran, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2773-7419","authenticated-orcid":true,"given":"Nasrin","family":"Khalesi","sequence":"additional","affiliation":[{"name":"Department of Neonatology, Ali Asghar Hospital, Iran University of Medical Sciences, (IUMS), Tehran, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9851-6771","authenticated-orcid":true,"given":"Leila","family":"Allahqoli","sequence":"additional","affiliation":[{"name":"Endometriosis Research Center, Iran University of Medical Sciences (IUMS), Tehran, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"20123","published-online":{"date-parts":[[2020,5,1]]},"reference":[{"key":"R1","doi-asserted-by":"crossref","first-page":"30","DOI":"10.20286\/jpn-040130","article-title":"The prevalence of acute kidney injury in neonates with asphyxia","volume":"4","author":"Saboute M","year":"2016","journal-title":"J Pediatr Nephrol"},{"key":"R2","doi-asserted-by":"publisher","DOI":"10.7196\/samj.9140"},{"key":"R3","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2010.11.010"},{"key":"R4","doi-asserted-by":"publisher","DOI":"10.3233\/NPM-161614"},{"key":"R5","doi-asserted-by":"publisher","DOI":"10.1007\/s12350-014-0036-9"},{"key":"R6","first-page":"928","article-title":"Renal failure in asphyxiated neonates","volume":"42","author":"Gupta B","year":"2005","journal-title":"Indian Pediatr"},{"key":"R7","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2014-3819"},{"key":"R8","doi-asserted-by":"crossref","first-page":"60","DOI":"10.30750\/ijpbr.2.2.11","article-title":"Acute Kidney Injury (AKI) in perinatal asphyxia","volume":"2","author":"Gopal G","year":"2014","journal-title":"Indian Journal of Pharmaceutical and Biological Research"},{"key":"R9","doi-asserted-by":"crossref","first-page":"p281","DOI":"10.1016\/j.siny.2015.06.001","article-title":"editor Fanaroff and Martin\u2019s Neonatal-Perinatal Medicine\u2013Diseases of the Fetus and Infant","volume":"20","author":"Miall L","year":"2015","journal-title":"Semin Fetal Neonatal Med"},{"key":"R10","doi-asserted-by":"publisher","DOI":"10.1007\/s13167-011-0100-3"},{"key":"R11","unstructured":"Ridha M. 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