{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T17:32:01Z","timestamp":1787506321550,"version":"build-2736575974"},"reference-count":54,"publisher":"Maad Rayan Publishing Company","issue":"5","content-domain":{"domain":["www.aimjournal.ir"],"crossmark-restriction":false},"short-container-title":["Arch Iran Med"],"abstract":"<jats:p>\n                    <jats:bold>Background<\/jats:bold>\n                    : M\u00e9ni\u00e8re\u2019s disease (MD) is a common inner ear disorder which is characterized by recurrent attacks of vertigo, fluctuating sensorineural hearing loss (SNHL), tinnitus, and a sense of fullness in the affected ear. MD is a complex disorder; although six genes have been linked to familial autosomal dominant form of the disease, in many cases, the exact genetic etiology remains elusive.\n                    <jats:bold>Methods<\/jats:bold>\n                    : To elucidate the genetic causes of MD in an Iranian family, we performed exome sequencing on all members of the family: consanguineous parents and four children (two affected and two unaffected). Variant filtering was completed using a customized workflow keeping variants based on segregation with MD in autosomal recessive (AR) inheritance pattern, minor allele frequency (MAF), and\n                    <jats:italic>in-silico<\/jats:italic>\n                    prediction of pathogenicity.\n                    <jats:bold>Results<\/jats:bold>\n                    : Analysis revealed that in this family, 970 variants co-segregated with MD in AR pattern, out of which eight variants (one intergenic, four intronic, and three exonic) were extremely rare. The exonic variants included a synonymous substitution in\n                    <jats:italic>USP3<\/jats:italic>\n                    gene, an in-frame deletion in\n                    <jats:italic>ZBED2<\/jats:italic>\n                    gene, and a rare, highly conserved deleterious missense alteration in\n                    <jats:italic>LSAMP<\/jats:italic>\n                    gene.\n                    <jats:bold>Conclusion<\/jats:bold>\n                    : The phenotype observed in the proband described here, i.e. vertigo, poor sense of smell, tinnitus, and borderline hearing ability, may originate from aberrant changes in the cerebellum and limbic system due to a deleterious mutation in the\n                    <jats:italic>LSAMP<\/jats:italic>\n                    gene; hence,\n                    <jats:italic>LSAMP<\/jats:italic>\n                    mutation is a possible candidate for the etiology of MD in this family.\n                  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