{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T20:06:18Z","timestamp":1779393978692,"version":"3.53.1"},"reference-count":0,"publisher":"Maad Rayan Publishing Company","issue":"11","content-domain":{"domain":["www.aimjournal.ir"],"crossmark-restriction":false},"short-container-title":["Arch Iran Med"],"abstract":"<jats:p>\n            <jats:bold>Background:<\/jats:bold> In Iran, zoonotic and anthroponotic cutaneous leishmaniasis (CL) are caused by Leishmania major and L. tropica respectively. Despite extensive studies, no effective therapies have ever been reported for CL. The main objective of this research was to determine and compare the three different protocols for treatment of CL patients referring to Skin Diseases and Leishmaniasis Research Center (SDLRC), affiliated to Isfahan University of Medical Sciences, Isfahan, Iran from September 2017 to October 2018. <jats:bold>Methods: <\/jats:bold>In a randomized controlled parallel groups clinical trial, 150 selected CL patients who met our inclusion criteria were randomly assigned to one of the three therapy groups: A, intra-lesional glucantime plus 50% trichloroacetic acid (TCA), B, intralesional glucantime and C, systemic glucantime. All patients in the three groups received the complete course of treatment and were followed for 6 months. To identify the etiologic agents, smears from their lesions were prepared and PCR-RFLP was used after parasite culture. Also, clinical characteristics, history of previous involvement, endemic emigration and demographic data were collected. <jats:bold>Results:<\/jats:bold> The results showed that the mean value of healing period was 53.12 \u00b1 25.88 (median: 45, IQR: Q1 = 30-Q3 = 77) days in group A, 57.22 \u00b1 44.02 (median: 42.5, IQR: Q1 = 30-Q3 = 60) days in group B, and 73.56 \u00b1 41.08 (median: 71, IQR: Q1 = 45-Q3 = 90) days in group C; the observed differences were statistically significant (<jats:italic>P<\/jats:italic>=0.024). There was a significant difference between group A and group C (<jats:italic>P<\/jats:italic> = 0.049), and between group B and group C (<jats:italic>P<\/jats:italic> = 0.047) in terms of mean healing period. Finally, complete recovery rates of 80%, 62% and 42% were shown in the three medicinal groups of A, B and C, respectively (<jats:italic>P<\/jats:italic> = 0.022). <jats:bold>Conclusion:<\/jats:bold> In this study, the average duration of lesion healing among the three groups was the shortest in patients with IL glucantime plus 50% TCA treatment regimen. Also, the use of 50% TCA in patients suffering from CL was associated with a significant improvement in the depth of scars, the time and the percentage of recovery, and the low cost of this agent in the treatment of CL. <\/jats:p>","DOI":"10.34172\/aim.2020.98","type":"journal-article","created":{"date-parts":[[2020,11,11]],"date-time":"2020-11-11T15:22:04Z","timestamp":1605108124000},"page":"740-748","update-policy":"https:\/\/doi.org\/10.34172\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Comparison of Three Different Therapies for Cutaneous Leishmaniasis and Identification of the Etiologic Isolates in Isfahan, Iran"],"prefix":"10.34172","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0666-556X","authenticated-orcid":true,"given":"Latifeh","family":"Abdellahi","sequence":"first","affiliation":[{"name":"Department of Biology, School of Basic Science, Science and Research Branch, Islamic Azad University, Tehran, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8787-4162","authenticated-orcid":true,"given":"Seyed Hossein","family":"Hejazi","sequence":"additional","affiliation":[{"name":"Skin Diseases and Leishmaniasis Research Center, Department of Parasitology and Mycology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nour","family":"Amirmozafari","sequence":"additional","affiliation":[{"name":"Iran University of Medical Sciences, School of Medicine, Microbiology Department, Tehran, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fattah","family":"Sotoodehnejadnematalahi","sequence":"additional","affiliation":[{"name":"Department of Biology, School of Basic Science, Science and Research Branch, Islamic Azad University, Tehran, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"20123","published-online":{"date-parts":[[2020,11,1]]},"container-title":["Archives of Iranian Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.aimjournal.ir\/PDF\/aim-23-740.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.aimjournal.ir\/PDF\/aim-23-740.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,11,11]],"date-time":"2020-11-11T15:22:04Z","timestamp":1605108124000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.aimjournal.ir\/Article\/aim-13565"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,11,1]]},"references-count":0,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2020,11]]}},"URL":"https:\/\/doi.org\/10.34172\/aim.2020.98","relation":{},"ISSN":["1029-2977","1735-3947"],"issn-type":[{"value":"1029-2977","type":"print"},{"value":"1735-3947","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,11,1]]},"assertion":[{"value":"Academy of Medical Sciences of the I.R. Iran","name":"journal_owner","label":"Journal Owner"},{"value":"Academy of Medical Sciences of the I.R. Iran","name":"journal_publisher","label":"Journal Publisher"}]}}