{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T23:49:27Z","timestamp":1771026567268,"version":"3.50.1"},"reference-count":0,"publisher":"Maad Rayan Publishing Company","issue":"9","content-domain":{"domain":["aimjournal.ir"],"crossmark-restriction":false},"short-container-title":["Arch Iran Med"],"published-print":{"date-parts":[[2021,9,1]]},"abstract":"<jats:p>Background: Multidrug resistance pathogens are important heath challenges. In this study, the antibacterial activity of 20 plant extracts was tested against standard as well as 20 multidrug-resistant (MDR) strains of Pseudomonas aeruginosa and Escherichia coli. The most active plant extract (Quercus infectoria) was selected for the synergistic activity assay. Methods: Plant extracts were prepared by maceration using water, methanol and ethanol. The antibacterial activity of extracts was determined by both broth and agar dilution methods. The synergistic activity of QIG with ceftazidime (CAZ) was evaluated by checker board assay. Antioxidant activity was determined by colorimetric Ferric reducing antioxidant power (FRAP) assay.  Results: Only the methanol extract of QIG inhibited the growth of all the bacterial strains at a concentration of 1000 \u00b5g\/mL. Other active extracts were Myrtus communis and Eucalyptus globulus inhibiting the growth of most bacterial strains tested at 2000 \u00b5g\/ mL. In checker board assay, the minimum inhibitory concentration (MIC) to both QIG extract and CAZ was reduced. The MIC of CAZ was reduced from 64-4096 \u00b5g\/mL to 4 \u00b5g\/mL for P. aeruginosa and to 16 \u00b5g\/mL for E. coli isolates. Conclusion: The QIG extract exhibited potent antioxidant activity determined by FRAP assay. The result of this study showed a strong synergistic activity between QIC and CAZ on P. aeruginosa and E. coli. The activity within ethyl acetate-methanol (7:3) fraction indicates that the active components of the plant have a semi-polar nature and further work with this fraction may lead to understanding the mechanism of this synergistic activity. <\/jats:p>","DOI":"10.34172\/aim.2021.98","type":"journal-article","created":{"date-parts":[[2021,10,19]],"date-time":"2021-10-19T08:23:24Z","timestamp":1634631804000},"page":"684-688","update-policy":"https:\/\/doi.org\/10.34172\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Novel Synergistic Activity of <i>Quercus infectoria<\/i> Gall Extract with Ceftazidime Against Standard and Multiple Drug Resistant <i>Pseudomonas aeruginosa<\/i> and <i>Escherichia coli<\/i> Isolates"],"prefix":"10.34172","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3909-3630","authenticated-orcid":true,"given":"Elham","family":"Isaei","sequence":"first","affiliation":[{"name":"Student Research Committee, Kerman University of Medical Sciences, Kerman, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8320-3385","authenticated-orcid":true,"given":"Shahla","family":"Mansouri","sequence":"additional","affiliation":[{"name":"Medical Mycology and Bacteriology Research Center, Kerman University of Medical Sciences, Kerman, Iran"},{"name":"Department of Medical Microbiology (Bacteriology & Virology), Afzalipour Faculty of Medicine, Kerman University of Medical Sciences, Kerman, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maryam","family":"Rahmani","sequence":"additional","affiliation":[{"name":"Research Center of Tropical and Infectious Diseases, Kerman University of Medical Sciences, Kerman, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fariba","family":"Sharififar","sequence":"additional","affiliation":[{"name":"Herbal and Traditional Medicines Research Center, Kerman University of Medical Sciences, Kerman, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Atefeh","family":"Salary","sequence":"additional","affiliation":[{"name":"Student Research Committee, Kerman University of Medical Sciences, Kerman, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"20123","published-online":{"date-parts":[[2021,9,1]]},"container-title":["Archives of Iranian Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/aimjournal.ir\/PDF\/aim-24-684.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/aimjournal.ir\/PDF\/aim-24-684.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,10,19]],"date-time":"2021-10-19T08:23:24Z","timestamp":1634631804000},"score":1,"resource":{"primary":{"URL":"http:\/\/aimjournal.ir\/Article\/aim-19516"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,9,1]]},"references-count":0,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2021,9]]}},"URL":"https:\/\/doi.org\/10.34172\/aim.2021.98","relation":{},"ISSN":["1029-2977","1735-3947"],"issn-type":[{"value":"1029-2977","type":"print"},{"value":"1735-3947","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,9,1]]},"assertion":[{"value":"Academy of Medical Sciences of I.R. Iran","name":"journal_owner","label":"Journal Owner"},{"value":"Academy of Medical Sciences of I.R. Iran","name":"journal_publisher","label":"Journal Publisher"},{"value":"2020-09-04","order":1,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-04-21","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-09-01","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}