{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,24]],"date-time":"2025-12-24T12:19:21Z","timestamp":1766578761605,"version":"3.37.3"},"reference-count":28,"publisher":"Maad Rayan Publishing Company","issue":"6","content-domain":{"domain":["aimjournal.ir"],"crossmark-restriction":false},"short-container-title":["Arch Iran Med"],"published-print":{"date-parts":[[2022,6,1]]},"abstract":"<jats:p>Background: The Sydney system offers a standard biopsy protocol for detection and follow-up of gastric preneoplastic lesions such as intestinal metaplasia (IM). The highest frequency of cardia-type gastric adenocarcinoma (GA) in Iran has been documented in the north-western part of the country. This study aims to investigate the effect of the addition of mucosal biopsies of gastric cardia to the standard Sydney protocol on the rate of detection of IM in the asymptomatic residents of this high-risk region for proximal gastric cancer. Methods: A retrospective new analysis was performed on the previous data obtained in cross-sectional endoscopic screening in 2000 as well as a biopsy study of 508 asymptomatic volunteer residents in Meshkinshahr district, Ardabil province. The screening study was conducted in a group of residents aged 40 years and older who did not have any previous GI or hemodynamic problems. Results: Intestinal metaplasia at the Sydney protocol sampling sites was detected in 107 samples belonging to 76 of the 508 (14.99%) volunteers. Twenty-one patients had IM at the cardia. Of these, five patients had IM-cardia (IM only at the cardia). Therefore, adding a cardia biopsy to the set of biopsies diagnosed five more IM cases which were not diagnosed on the standard Sydney protocol (P=0.062). Conclusion: The addition of a biopsy from the cardia to the Sydney protocol biopsy set does not seem to improve the frequency of detection of IM in the residents of this high-risk geographic area for proximal gastric carcinoma.<\/jats:p>","DOI":"10.34172\/aim.2022.63","type":"journal-article","created":{"date-parts":[[2022,7,12]],"date-time":"2022-07-12T09:31:53Z","timestamp":1657618313000},"page":"394-398","update-policy":"https:\/\/doi.org\/10.34172\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Does Adding a Cardia Biopsy Improve Gastric Intestinal Metaplasia Detection Rate by the Sydney System Protocol?"],"prefix":"10.34172","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1361-2519","authenticated-orcid":true,"given":"Ghazaleh","family":"Soltani","sequence":"first","affiliation":[{"name":"Digestive Disease Research Center, Digestive Disease Research Institute, Tehran University of Medical Sciences, Tehran, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bahar","family":"Saberzadeh- Ardestani","sequence":"additional","affiliation":[{"name":"Digestive Disease Research Center, Digestive Disease Research Institute, Tehran University of Medical Sciences, Tehran, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masoud","family":"Sotoudeh","sequence":"additional","affiliation":[{"name":"Digestive Disease Research Center, Digestive Disease Research Institute, Tehran University of Medical Sciences, Tehran, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Siavosh","family":"Naseri -Moghaddam","sequence":"additional","affiliation":[{"name":"Digestive Disease Research Center, Digestive Disease Research Institute, Tehran University of Medical Sciences, Tehran, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohammad Hossein","family":"Derakhshan","sequence":"additional","affiliation":[{"name":"Institute of Infection, Immunity & Inflammation, University of Glasgow, Glasgow, United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiva","family":"Saffar","sequence":"additional","affiliation":[{"name":"Department of Pathology, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amir","family":"Kasaeian","sequence":"additional","affiliation":[{"name":"Digestive Disease Research Center, Digestive Disease Research Institute, Tehran University of Medical Sciences, Tehran, Iran"},{"name":"Hematology, Oncology and Stem Cell Transplantation Research Center, Tehran University of Medical Sciences, Tehran, Iran, Shariati Hospital, Tehran University of Medical"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"MohammadReza","family":"Chavoshi","sequence":"additional","affiliation":[{"name":"Department of Radiology, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1397-4846","authenticated-orcid":true,"given":"Alireza","family":"Sima","sequence":"additional","affiliation":[{"name":"Digestive Disease Research Center, Digestive Disease Research Institute, Tehran University of Medical Sciences, Tehran, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"20123","published-online":{"date-parts":[[2022,6,1]]},"reference":[{"key":"R1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2019.07.045"},{"key":"R2","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21492"},{"key":"R3","doi-asserted-by":"publisher","DOI":"10.1002\/cam4.2390"},{"key":"R4","doi-asserted-by":"publisher","DOI":"10.1016\/j.critrevonc.2009.01.004"},{"key":"R5","doi-asserted-by":"publisher","DOI":"10.1016\/s0959-8049(01)00267-2"},{"key":"R6","doi-asserted-by":"publisher","DOI":"10.1097\/cej.0000000000000480"},{"key":"R7","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v12.i3.354"},{"key":"R8","first-page":"576","article-title":"Gastric cancer in Iran: epidemiology and risk factors","volume":"12","author":"Malekzadeh R","year":"2009","journal-title":"Arch Iran Med"},{"key":"R9","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2003.035857"},{"key":"R10","doi-asserted-by":"publisher","DOI":"10.1053\/gast.1996.v111.pm8898634"},{"key":"R11","doi-asserted-by":"publisher","DOI":"10.1053\/hupa.2003.3"},{"key":"R12","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.11359"},{"key":"R13","doi-asserted-by":"publisher","DOI":"10.1136\/jclinpath-2015-202858"},{"key":"R14","first-page":"76","article-title":"Gastric cardia cancer; 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