{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,13]],"date-time":"2025-11-13T12:45:03Z","timestamp":1763037903088,"version":"3.37.3"},"reference-count":0,"publisher":"Maad Rayan Publishing Company","issue":"2","content-domain":{"domain":["journalaim.com"],"crossmark-restriction":false},"short-container-title":["Arch Iran Med"],"published-print":{"date-parts":[[2023,2,1]]},"abstract":"<jats:p>Background: The numerical and structural abnormalities of chromosomes are the most common cause of infertility. Here, we evaluated the prevalence and types of chromosomal abnormalities in Iranian infertile patients. Methods: We enrolled 1750 couples of reproductive age with infertility, who referred to infertility clinics in Tehran during 2014- 2019, in order to perform chromosomal analysis. Peripheral blood samples were obtained from all couples and chromosomal abnormalities were evaluated by G-banded metaphase karyotyping. In some cases, the detected abnormalities were confirmed using fluorescence in-situ hybridization (FISH). Results: We detected various chromosomal abnormalities in 114\/3500 (3.257%) patients with infertility. The prevalence of chromosomal abnormalities was 44\/114 (38.596%) among infertile females and 70\/114 (61.403%) among infertile males. Structural chromosomal abnormalities were found in 27\/1750 infertile females and 35\/1750 infertile males. Numerical chromosomal abnormalities were found in 17\/1750 of females and 35\/1750 of males. The 45, XY, rob (13;14) (p10q10) translocation and Klinefelter syndrome (47, XXY) were the most common structural and numerical chromosomal abnormalities in the Iranian infertile patients, respectively. Conclusion: In general, we found a high prevalence of chromosomal abnormalities in Iranian patients with reproductive problems. Our study highlights the importance of cytogenetic studies in infertile patients before starting infertility treatments approaches.<\/jats:p>","DOI":"10.34172\/aim.2023.17","type":"journal-article","created":{"date-parts":[[2023,6,28]],"date-time":"2023-06-28T05:58:08Z","timestamp":1687931888000},"page":"110-116","update-policy":"https:\/\/doi.org\/10.34172\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Prevalence of Chromosomal Abnormalities in Iranian Patients with Infertility"],"prefix":"10.34172","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-1867-4364","authenticated-orcid":true,"given":"Saima","family":"Abbaspour","sequence":"first","affiliation":[{"name":"Cellular and Molecular Research Center, Faculty of Medicine, Guilan University of Medical Sciences, Rasht, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8781-1177","authenticated-orcid":true,"given":"Alireza","family":"Isazadeh","sequence":"additional","affiliation":[{"name":"Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matin","family":"Heidari","sequence":"additional","affiliation":[{"name":"Ariagene Medical Genetics Laboratory, Qom, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masoud","family":"Heidari","sequence":"additional","affiliation":[{"name":"Department of Animal Biology, Faculty of Natural Sciences, University of Tabriz, Tabriz, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Saba","family":"Hajazimian","sequence":"additional","affiliation":[{"name":"Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Morteza","family":"Soleyman-Nejad","sequence":"additional","affiliation":[{"name":"Ariagene Medical Genetics Laboratory, Qom, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohammad Hossein","family":"Taskhiri","sequence":"additional","affiliation":[{"name":"Ariagene Medical Genetics Laboratory, Qom, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manzar","family":"Bolhassani","sequence":"additional","affiliation":[{"name":"Ariagene Medical Genetics Laboratory, Qom, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amir Hossein","family":"Ebrahimi","sequence":"additional","affiliation":[{"name":"Ariagene Medical Genetics Laboratory, Qom, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Parvaneh","family":"Keshavarz","sequence":"additional","affiliation":[{"name":"Cellular and Molecular Research Center, Faculty of Medicine, Guilan University of Medical Sciences, Rasht, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zahra","family":"Shiri","sequence":"additional","affiliation":[{"name":"Ariagene Medical Genetics Laboratory, Qom, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6394-0970","authenticated-orcid":true,"given":"Mansour","family":"Heidari","sequence":"additional","affiliation":[{"name":"Ariagene Medical Genetics Laboratory, Qom, Iran"},{"name":"Department of Medical Genetics, Tehran University of Medical Sciences (TUMS), Tehran, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"20123","published-online":{"date-parts":[[2023,2,1]]},"container-title":["Archives of Iranian Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/journalaim.com\/PDF\/aim-26-110.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/journalaim.com\/PDF\/aim-26-110.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,6,28]],"date-time":"2023-06-28T05:58:09Z","timestamp":1687931889000},"score":1,"resource":{"primary":{"URL":"http:\/\/journalaim.com\/Article\/aim-26296"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,2,1]]},"references-count":0,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2023,2,1]]},"published-print":{"date-parts":[[2023,2,1]]}},"URL":"https:\/\/doi.org\/10.34172\/aim.2023.17","relation":{},"ISSN":["1029-2977","1735-3947"],"issn-type":[{"type":"print","value":"1029-2977"},{"type":"electronic","value":"1735-3947"}],"subject":[],"published":{"date-parts":[[2023,2,1]]},"assertion":[{"value":"Academy of Medical Sciences of I.R. Iran","name":"journal_owner","label":"Journal Owner"},{"value":"Academy of Medical Sciences of I.R. Iran","name":"journal_publisher","label":"Journal Publisher"},{"value":"2022-06-13","order":1,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-09-13","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-02-01","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}