{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T22:42:17Z","timestamp":1792017737688,"version":"4.4.0"},"reference-count":0,"publisher":"Maad Rayan Publishing Company","issue":"8","content-domain":{"domain":["journalaim.com"],"crossmark-restriction":false},"short-container-title":["Arch Iran Med"],"published-print":{"date-parts":[[2023,8,1]]},"abstract":"<jats:p>Background: miRNAs are non-coding RNAs participating actively in the post-translational regulation of oncogenes, tumor suppressor, and DNA repair genes implicated in colorectal cancer (CRC). This study aims to examine the association of the variants miR-27a (rs895819 A&gt;G), miR-196a2 (rs11614913 T&gt;G) and miR-146a (rs2910164 C&gt;G) in Mexican CRC patients. Methods: DNA samples from 183 patients and 186 healthy Mexican subjects were analyzed. Variants were identified by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) methodology. Association was calculated by the odds ratio (OR) and adjusted by the Bonferroni test. Results: Patients carrying the G\/G genotype of the rs895819 variant in the miR-27a gene showed an increased risk of CRC (19% vs 12%, P=0.013). A similar tendency was noticed for patients younger than 50 years carrying A\/G (48% vs 41%, P=0.014). The A\/G genotype in TNM stages I+II (55.7% vs 40.8%, P=0.011) and tumor location in the colon (69.5 vs 40.8%, P=0.001) were also increased. For the variant rs11614913 of the miR-196a2 gene, carriers of the C\/C genotype showed an increased risk of CRC (32% vs 22%, P=0.009). This genotype was more frequent in TNM stage III+IV (36.8% vs 22.5%, P=0.007) and the tumor had a more recurrent location in the rectum (31.6% vs 22.5%, P=0.013). The rs2910164 variant of the miR-146a gene was found to have no significant risk associations. Conclusion: Our results reveal that the rs895819 variant in miR-27a and rs11614913 in miR-196a2 have a substantial impact on the development of CRC. <\/jats:p>","DOI":"10.34172\/aim.2023.67","type":"journal-article","created":{"date-parts":[[2023,11,8]],"date-time":"2023-11-08T08:07:15Z","timestamp":1699430835000},"page":"439-446","update-policy":"https:\/\/doi.org\/10.34172\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Functional Variants in MicroRNAs (rs895819, rs11614913 and rs2910164) Are Associated with Susceptibility and Clinicopathological Features in Mexican Patients with Colorectal Cancer"],"prefix":"10.34172","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9695-9771","authenticated-orcid":true,"given":"Yuri Giovanna Vanessa","family":"Trujillo-Fern\u00e1ndez","sequence":"first","affiliation":[{"name":"Molecular Medicine Division, Centro de Investigaci\u00f3n Biom\u00e9dica de Occidente, Instituto Mexicano del Seguro Social (IMSS), Guadalajara, Jalisco, M\u00e9xico"},{"name":"Doctorado en Gen\u00e9tica Humana, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Jalisco, M\u00e9xico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carmen","family":"Yzabal-Barbedillo","sequence":"additional","affiliation":[{"name":"Molecular Medicine Division, Centro de Investigaci\u00f3n Biom\u00e9dica de Occidente, Instituto Mexicano del Seguro Social (IMSS), Guadalajara, Jalisco, M\u00e9xico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4097-8671","authenticated-orcid":true,"given":"Anil\u00fa Margarita","family":"Saucedo-Sarina\u00f1a","sequence":"additional","affiliation":[{"name":"Department of Devices and Systems I, Facultad de Medicina. Decanato Ciencias de la Salud, Universidad Aut\u00f3noma de Guadalajara (UAG). Zapopan, Jalisco, M\u00e9xico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C\u00e9sar de Jes\u00fas","family":"Tovar-J\u00e1come","sequence":"additional","affiliation":[{"name":"Molecular Medicine Division, Centro de Investigaci\u00f3n Biom\u00e9dica de Occidente, Instituto Mexicano del Seguro Social (IMSS), Guadalajara, Jalisco, M\u00e9xico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miriam Yadira","family":"God\u00ednez-Rodr\u00edguez","sequence":"additional","affiliation":[{"name":"Molecular Medicine Division, Centro de Investigaci\u00f3n Biom\u00e9dica de Occidente, Instituto Mexicano del Seguro Social (IMSS), Guadalajara, Jalisco, M\u00e9xico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6607-5553","authenticated-orcid":true,"given":"Patricio","family":"Barros-N\u00fa\u00f1ez","sequence":"additional","affiliation":[{"name":"Doctorado en Gen\u00e9tica Humana, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Jalisco, M\u00e9xico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4539-1693","authenticated-orcid":true,"given":"Martha Patricia","family":"Gallegos-Arreola","sequence":"additional","affiliation":[{"name":"Genetic Division, Centro de Investigaci\u00f3n Biom\u00e9dica de Occidente, Instituto Mexicano del Seguro Social (IMSS), Guadalajara, Jalisco, M\u00e9xico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clara Ibet","family":"Ju\u00e1rez-V\u00e1zquez","sequence":"additional","affiliation":[{"name":"Department of Devices and Systems I, Facultad de Medicina. Decanato Ciencias de la Salud, Universidad Aut\u00f3noma de Guadalajara (UAG). Zapopan, Jalisco, M\u00e9xico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6757-731X","authenticated-orcid":true,"given":"Tom\u00e1s Daniel","family":"Pineda-Razo","sequence":"additional","affiliation":[{"name":"Medical Oncology Service, Hospital de Especialidades, Instituto Mexicano del Seguro Social (IMSS), Guadalajara, Jalisco, M\u00e9xico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8352-236X","authenticated-orcid":true,"given":"Mar\u00eda Eugenia","family":"Mar\u00edn-Contreras","sequence":"additional","affiliation":[{"name":"Gastroenterology Service, Hospital de Especialidades, Instituto Mexicano del Seguro Social (IMSS), Guadalajara, Jalisco, M\u00e9xico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0387-4996","authenticated-orcid":true,"given":"M\u00f3nica Alejandra","family":"Rosales-Reynoso","sequence":"additional","affiliation":[{"name":"Molecular Medicine Division, Centro de Investigaci\u00f3n Biom\u00e9dica de Occidente, Instituto Mexicano del Seguro Social (IMSS), Guadalajara, Jalisco, M\u00e9xico"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"20123","published-online":{"date-parts":[[2023,8,1]]},"container-title":["Archives of Iranian Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/journalaim.com\/PDF\/aim-26-439.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/journalaim.com\/PDF\/aim-26-439.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,8]],"date-time":"2023-11-08T08:07:15Z","timestamp":1699430835000},"score":1,"resource":{"primary":{"URL":"http:\/\/journalaim.com\/Article\/aim-27058"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,8,1]]},"references-count":0,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2023,8,1]]},"published-print":{"date-parts":[[2023,8,1]]}},"URL":"https:\/\/doi.org\/10.34172\/aim.2023.67","relation":{},"ISSN":["1029-2977","1735-3947"],"issn-type":[{"value":"1029-2977","type":"print"},{"value":"1735-3947","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,8,1]]},"assertion":[{"value":"Academy of Medical Sciences of I.R. Iran","name":"journal_owner","label":"Journal Owner"},{"value":"Academy of Medical Sciences of I.R. Iran","name":"journal_publisher","label":"Journal Publisher"},{"value":"2022-12-10","order":1,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-07-03","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-08-01","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}