{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,22]],"date-time":"2025-02-22T00:15:05Z","timestamp":1740183305556,"version":"3.37.3"},"reference-count":48,"publisher":"Maad Rayan Publishing Company","issue":"8","content-domain":{"domain":["journalaim.com"],"crossmark-restriction":false},"short-container-title":["Arch Iran Med"],"published-print":{"date-parts":[[2024,8,1]]},"abstract":"<jats:p>Background: Peripheral neuropathic pain is a result of damage\/illness of the peripheral nerves. The mechanisms caused by its pathophysiology are not completely understood. Methods: Imipramine is a tricyclic antidepressant that is sometimes used to treat neuropathic pain. Moreover, citicoline is considered a novel adjuvant for painful disorders such as neuropathic pain. So, a possible interaction between imipramine and citicoline on pain behavior was examined in nerve-ligated mice using tail-flick and hot plate tests. Results: The results indicated that induction of neuropathic pain by sciatic nerve ligation caused hyperalgesia in nerve-ligated mice. On the other hand, intraperitoneal (i.p.) administration of citicoline (50, 75, and 100 mg\/kg), and imipramine (2.5 and 5 mg\/kg) induced anti-hyperalgesic and anti-nociceptive effects in nerve-ligated mice. Furthermore, citicoline potentiated the anti-hyperalgesic and anti-nociceptive effects of imipramine when they were co-administrated in nerve-ligated mice. Interestingly, there was an additive effect between imipramine and citicoline upon induction of anti-hyperalgesic and anti-nociceptive effects in nerve-ligated mice. Conclusion: Therefore, it can be concluded that citicoline (as an adjuvant substance) enhanced the efficacy of imipramine for the modulation of pain behavior in nerve-ligated mice<\/jats:p>","DOI":"10.34172\/aim.28772","type":"journal-article","created":{"date-parts":[[2024,9,9]],"date-time":"2024-09-09T05:39:01Z","timestamp":1725860341000},"page":"456-464","update-policy":"https:\/\/doi.org\/10.34172\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Potentiation of Imipramine-Induced Anti-hyperalgesic and Anti-Nociceptive Effects by Citicoline in the Sciatic Nerve Ligated Mice"],"prefix":"10.34172","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6103-9449","authenticated-orcid":true,"given":"Negar","family":"Raissi-Dehkordi","sequence":"first","affiliation":[{"name":"School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nastaran","family":"Raissi-Dehkordi","sequence":"additional","affiliation":[{"name":"School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bardia","family":"Hajikarimloo","sequence":"additional","affiliation":[{"name":"School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fatemeh","family":"Khakpai","sequence":"additional","affiliation":[{"name":"Department of Physiology, Faculty of Medicine, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran"},{"name":"Cognitive and Neuroscience Research Center (CNRC), Tehran Medical Sciences, Islamic Azad University, Tehran, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0688-5378","authenticated-orcid":true,"given":"Moammad-Reza","family":"Zarrindast","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran"},{"name":"Iranian National Center for Addiction Studies, Tehran University of Medical Sciences, Tehran, Iran"},{"name":"Institute for Cognitive Science Studies (ICSS), Tehran, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"20123","published-online":{"date-parts":[[2024,8,1]]},"reference":[{"key":"R1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.neuro.051508.135531"},{"key":"R2","doi-asserted-by":"publisher","DOI":"10.4081\/ejtm.2017.6488"},{"key":"R3","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0773.2001.d01-139.x"},{"key":"R4","doi-asserted-by":"publisher","DOI":"10.1515\/jcim-2016-0066"},{"key":"R5","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2006.09.021"},{"key":"R6","doi-asserted-by":"publisher","DOI":"10.5935\/1806-0013.20160043"},{"key":"R7","doi-asserted-by":"publisher","DOI":"10.1016\/s0304-3959(98)00045-1"},{"key":"R8","doi-asserted-by":"publisher","DOI":"10.1152\/jn.01088.2012"},{"key":"R9","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2010.08.067"},{"key":"R10","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2009.09.030"},{"key":"R11","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2014.11.039"},{"key":"R12","doi-asserted-by":"publisher","DOI":"10.1038\/srep26955"},{"key":"R13","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejpain.2007.10.002"},{"key":"R14","doi-asserted-by":"crossref","unstructured":"Yalcin I, Megat S, Barthas F, Waltisperger E, Kremer M, Salvat E, et al. 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