{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T17:32:31Z","timestamp":1788802351068,"version":"build-2803163510"},"reference-count":0,"publisher":"Maad Rayan Publishing Company","issue":"5","content-domain":{"domain":["journalaim.com"],"crossmark-restriction":false},"short-container-title":["Arch Iran Med"],"published-print":{"date-parts":[[2025,5,1]]},"abstract":"<jats:p>Background: Immunoglobulin G4-related disease (IgG4-RD) is a rare, chronic inflammatory condition characterized by fibrosis and tendency for multi-organ involvement. This study aims to analyze the clinical characteristics associated with multi-organ versus single-organ involvement in IgG4-RD, thereby enhancing clinicians\u2019 understanding of the differences between these two patient groups and ultimately improving patient prognosis. Methods: We performed a retrospective analysis of clinical data from 82 patients diagnosed with IgG4-RD admitted to Yichang Central People\u2019s Hospital between January 2019 and December 2024. Results: Among the 82 patients diagnosed with IgG4-RD, 47 patients (57.32%) exhibited involvement of multiple organs. The incidence of multi-organ involvement was significantly higher in male patients than female patients [63.49% vs. 36.84%, odds ratio (OR): 2.98, 95% confidence intervals (CI): 1.03\u20138.64, P&lt;0.05]. The misdiagnosis rate in the multi-organ involvement group was significantly higher than that in the single-organ involvement group (29.79% vs. 8.57%, OR: 4.525, 95% CI: 1.19\u201317.26, P&lt;0.05). In patients with involvement of the pancreas (72.50% vs. 42.86%, OR: 3.515, 95% CI: 1.39\u20138.86, P&lt;0.05), or lymph nodes (83.72% vs. 28.21%, OR: 13.091, 95% CI: 4.50\u201338.11, P&lt;0.05), the incidence of additional organ involvement was significantly higher than those with involvement of other organs. The eosinophil percentage [median difference (Hodges-Lehmann): 1.60%, 95% CI: 0.40\u20132.80, P&lt;0.05], absolute eosinophil count [median difference (Hodges-Lehmann): 0.10\u00d7109\/L , 95% CI: 0.30\u20130.16, P&lt;0.05], serum immunoglobulin G (IgG) levels [median difference (Hodges-Lehmann): 4.10 g\/L, 95% CI: 0.10\u20137.80, P&lt;0.05], and erythrocyte sedimentation rate (ESR) [median difference (Hodges-Lehmann): 30.50 mm\/h, 95% CI: 13.00\u201348.00, P&lt;0.05] were significantly higher in the multi-organ involvement group compared to the single-organ involvement group. There was a positive correlation between the number of involved organs and ESR (r=0.404, 95% CI: 0.166\u20130.597, P=0.001), eosinophil percentage (r=0.287, 95% CI: 0.068\u20130.480, P=0.009), absolute eosinophil count (r=0.293, 95% CI: 0.075\u20130.485, P=0.007), serum IgG levels (r=0.370, 95% CI: 0.130\u20130.570, P=0.003), and serum IgG4 levels (r=0.370, 95% CI: 0.130\u20130.570, P=0.003). Conclusion: The clinical features associated with multi-organ involvement in IgG4-RD are characterized by significant diversity and complexity. Clinicians must enhance their understanding of the characteristics associated with multi-organ involvement to more effectively improve patient prognosis.<\/jats:p>","DOI":"10.34172\/aim.34027","type":"journal-article","created":{"date-parts":[[2025,5,29]],"date-time":"2025-05-29T03:08:57Z","timestamp":1748488137000},"page":"303-312","update-policy":"https:\/\/doi.org\/10.34172\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Comparative Analysis of Clinical Characteristics in Multi-organ and Single-organ Involvement of IgG4-Related Disease: A Single-center Retrospective Study"],"prefix":"10.34172","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-7708-6219","authenticated-orcid":true,"given":"Dong-Ge","family":"Han","sequence":"first","affiliation":[{"name":"The First College of Clinical Medical Science, China Three Gorges University, Yichang, China"},{"name":"Institute of Digestive Disease, China Three Gorges University, Yichang, China"},{"name":"Department of Gastroenterology, Yichang Central People\u2019s Hospital, Yichang, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chun-Lin","family":"Ying","sequence":"additional","affiliation":[{"name":"The First College of Clinical Medical Science, China Three Gorges University, Yichang, China"},{"name":"Institute of Digestive Disease, China Three Gorges University, Yichang, China"},{"name":"Department of Gastroenterology, Yichang Central People\u2019s Hospital, Yichang, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zi-Ping","family":"Cai","sequence":"additional","affiliation":[{"name":"The First College of Clinical Medical Science, China Three Gorges University, Yichang, China"},{"name":"Institute of Digestive Disease, China Three Gorges University, Yichang, China"},{"name":"Department of Gastroenterology, Yichang Central People\u2019s Hospital, Yichang, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-0647-5419","authenticated-orcid":true,"given":"Qiao-Yun","family":"Tong","sequence":"additional","affiliation":[{"name":"The First College of Clinical Medical Science, China Three Gorges University, Yichang, China"},{"name":"Institute of Digestive Disease, China Three Gorges University, Yichang, China"},{"name":"Department of Gastroenterology, Yichang Central People\u2019s Hospital, Yichang, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7118-815X","authenticated-orcid":true,"given":"Wei","family":"Liu","sequence":"additional","affiliation":[{"name":"The First College of Clinical Medical Science, China Three Gorges University, Yichang, China"},{"name":"Institute of Digestive Disease, China Three Gorges University, Yichang, China"},{"name":"Department of Gastroenterology, Yichang Central People\u2019s Hospital, Yichang, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"20123","published-online":{"date-parts":[[2025,5,1]]},"container-title":["Archives of Iranian Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journalaim.com\/PDF\/aim-28-303.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journalaim.com\/PDF\/aim-28-303.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,29]],"date-time":"2025-05-29T03:08:57Z","timestamp":1748488137000},"score":1,"resource":{"primary":{"URL":"https:\/\/journalaim.com\/Article\/aim-34027"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5,1]]},"references-count":0,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2025,5,1]]},"published-print":{"date-parts":[[2025,5,1]]}},"URL":"https:\/\/doi.org\/10.34172\/aim.34027","relation":{},"ISSN":["1029-2977","1735-3947"],"issn-type":[{"value":"1029-2977","type":"print"},{"value":"1735-3947","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,5,1]]},"assertion":[{"value":"Academy of Medical Sciences of I.R. Iran","name":"journal_owner","label":"Journal Owner"},{"value":"Academy of Medical Sciences of I.R. Iran","name":"journal_publisher","label":"Journal Publisher"},{"value":"2025-01-25","order":1,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-04-08","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-05-01","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}