{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,20]],"date-time":"2025-11-20T09:17:07Z","timestamp":1763630227769,"version":"3.45.0"},"reference-count":0,"publisher":"Maad Rayan Publishing Company","issue":"10","content-domain":{"domain":["journalaim.com"],"crossmark-restriction":false},"short-container-title":["Arch Iran Med"],"published-print":{"date-parts":[[2025,10,1]]},"abstract":"<jats:p>Background: Pediatric central nervous system (CNS) tumors are among the most common childhood malignancies and a leading cause of cancer-related death. This study aimed to describe the histopathological spectrum of primary brain tumors in children over a 13-year period in a tertiary referral center in Iran. Methods: In this existing data study (EDS), we reviewed the medical records of 549 patients aged 0\u201317 years who underwent surgical resection of brain tumors between 2008 and 2020. Tumor characteristics, including histology, location, and World Health Organization (WHO 2016) grade, along with patient age and sex, were extracted. Descriptive and comparative analyses were conducted. Temporal trends for single-center in the number of pediatric brain tumor surgeries performed in our center were assessed using Poisson regression. Results: The mean age at diagnosis was 5.1 years, with a male-to-female ratio of 1.3:1. Pilocytic astrocytoma (20.9%) was the most common tumor, followed by medulloblastoma (15.3%) and ependymoma (11.3%). Tumors were nearly evenly distributed between supratentorial (48.6%) and infratentorial (48.5%) regions. Grade I tumors were most frequent overall, while Grade IV tumors were significantly more common in the infratentorial space (P&lt;0.001). No significant differences in tumor distribution were observed by sex or age group. The number of surgeries increased significantly over time (incidence rate ratio: 1.127\/year, P&lt;0.001), with no subgroup differences in temporal trend. Conclusion: This single-center study provides institutional-level insights into the histopathological characteristics of pediatric brain tumors. The predominance of low-grade tumors observed emphasizes the need for national pediatric neuro-oncology registries, particularly in low- and middle-income countries, to enable more representative data collection and planning.<\/jats:p>","DOI":"10.34172\/aim.34594","type":"journal-article","created":{"date-parts":[[2025,11,20]],"date-time":"2025-11-20T09:12:31Z","timestamp":1763629951000},"page":"543-550","update-policy":"https:\/\/doi.org\/10.34172\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Primary Pediatric Brain Tumors in a Tertiary Referral Center in Iran: A 13-Year Retrospective Analysis"],"prefix":"10.34172","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6272-2402","authenticated-orcid":true,"given":"Ghazaleh","family":"Kheiri","sequence":"first","affiliation":[{"name":"Department of Neurosurgery, Children\u2019s Medical Center, Tehran University of Medical Sciences, Tehran, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sadra","family":"Kheiri","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Isfahan University of Medical Sciences, Isfahan, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Milad","family":"Shafizadeh","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keyvan","family":"Tayebi Meybodi","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Children\u2019s Medical Center, Tehran University of Medical Sciences, Tehran, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Farideh","family":"Nejat","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Children\u2019s Medical Center, Tehran University of Medical Sciences, Tehran, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5771-1167","authenticated-orcid":true,"given":"Zohreh","family":"Habibi","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Children\u2019s Medical Center, Tehran University of Medical Sciences, Tehran, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"20123","published-online":{"date-parts":[[2025,10,1]]},"container-title":["Archives of Iranian Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journalaim.com\/PDF\/aim-28-543.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journalaim.com\/PDF\/aim-28-543.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,20]],"date-time":"2025-11-20T09:12:33Z","timestamp":1763629953000},"score":1,"resource":{"primary":{"URL":"https:\/\/journalaim.com\/Article\/aim-34594"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10,1]]},"references-count":0,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2025,10,1]]},"published-print":{"date-parts":[[2025,10,1]]}},"URL":"https:\/\/doi.org\/10.34172\/aim.34594","relation":{},"ISSN":["1029-2977","1735-3947"],"issn-type":[{"value":"1029-2977","type":"print"},{"value":"1735-3947","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,10,1]]},"assertion":[{"value":"Academy of Medical Sciences of I.R. Iran","name":"journal_owner","label":"Journal Owner"},{"value":"Academy of Medical Sciences of I.R. Iran","name":"journal_publisher","label":"Journal Publisher"},{"value":"2025-05-28","order":1,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-09-24","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-10-01","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}