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The Cochran-Armitage trend test and Joinpoint regression were employed to analyze the changes in disease trends. Results: During the study period, a total of 1,798 deaths from CeVDs were reported, with a mean age of 76.8\u00b113.2 years. The CMR and ASMR for CeVDs decreased from 38.4 and 28.3 per 100,000 population in 2016 to 30.9 and 23.3 per 100,000 in 2023 (P&lt;0.001). The trend decreased in both genders and urban and rural populations (P&lt;0.05). Joinpoint regression indicated a break point in 2018. Between 2018 and 2023, the ASMR trend decreased, with an annual percentage change of -7.98% (95% CI, -18.72% to -4.88%). Conclusion: This study reveals a significant decrease in CeVDs mortality in the region, indicating progress in therapeutic interventions. However, death rates in rural areas remain high. 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