{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,11]],"date-time":"2025-09-11T16:56:03Z","timestamp":1757609763694,"version":"3.44.0"},"reference-count":0,"publisher":"Maad Rayan Publishing Company","content-domain":{"domain":["apb.tbzmed.ac.ir"],"crossmark-restriction":false},"short-container-title":["Adv Pharm Bull"],"abstract":"<jats:p>Purpose: This systematic review aims to critically evaluate the safety and efficacy of PRP therapy in managing IC\/BPS. Methods: Two researchers independently searched related Databases and collected all studies from inception to December 5, 2023. Outcome indicators of symptom relief were pain scores self-assessment using the VAS system, IC symptoms using the O\u2019Leary-Sant score (OSS), urinary frequency, nocturia, PVR, voided volume, and functional bladder capacity. Results: Among 372 retrieved articles, 13 studies, including 426 patients were included. The pain of patients decreased significantly after treatment with PRP compared to the baseline values (MD: -1.93, 95% CI: -2.28, -1.58). All subgroup analyses revealed a decrease in VAS scores after PRP injection. IC symptoms using OSS, and ICSI decreased significantly after treatment. Conclusion: PRP therapy as a new and successful course of treatment may be a novel therapeutic approach in IC\/BPS cases. More study with the control arm is required to enhance treatment regimens for this difficult condition and to better understand the mechanisms of action of PRP in IC\/BPS.<\/jats:p>","DOI":"10.34172\/apb.025.45444","type":"journal-article","created":{"date-parts":[[2025,9,3]],"date-time":"2025-09-03T10:58:36Z","timestamp":1756897116000},"update-policy":"https:\/\/doi.org\/10.34172\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Platelet-Rich Plasma in interstitial cystitis\/bladder pain syndrome: A Systematic Review and Meta-analysis"],"prefix":"10.34172","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1494-7097","authenticated-orcid":true,"given":"Sakineh","family":"Hajebrahimi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0652-7693","authenticated-orcid":true,"given":"Fateme","family":"Tahmasbi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8209-2150","authenticated-orcid":true,"given":"Elham","family":"Jahantabi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gholamreza","family":"Hosseinpour","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8835-8151","authenticated-orcid":true,"given":"Rajesh","family":"LotfiTaneja","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9030-2106","authenticated-orcid":true,"given":"Hanieh","family":"Salehi-Pourmehr","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"20123","published-online":{"date-parts":[[2025,9,3]]},"container-title":["Advanced Pharmaceutical Bulletin"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/apb.tbzmed.ac.ir\/Inpress\/apb-45444.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/apb.tbzmed.ac.ir\/Inpress\/apb-45444.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,3]],"date-time":"2025-09-03T10:58:36Z","timestamp":1756897116000},"score":1,"resource":{"primary":{"URL":"https:\/\/apb.tbzmed.ac.ir\/Inpress\/apb-45444"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9,3]]},"references-count":0,"URL":"https:\/\/doi.org\/10.34172\/apb.025.45444","relation":{},"ISSN":["2228-5881","2251-7308"],"issn-type":[{"type":"print","value":"2228-5881"},{"type":"electronic","value":"2251-7308"}],"subject":[],"published":{"date-parts":[[2025,9,3]]},"assertion":[{"value":"Tabriz University of Medical Sciences","name":"journal_owner","label":"Journal Owner"},{"value":"Tabriz University of Medical Sciences","name":"journal_publisher","label":"Journal Publisher"},{"value":"2025-03-23","order":1,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-08-27","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-09-03","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}