{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,14]],"date-time":"2026-02-14T04:00:27Z","timestamp":1771041627185,"version":"3.50.1"},"reference-count":0,"publisher":"Maad Rayan Publishing Company","content-domain":{"domain":["apb.tbzmed.ac.ir"],"crossmark-restriction":false},"short-container-title":["Adv Pharm Bull"],"published-print":{"date-parts":[[2020,10,19]]},"abstract":"<jats:p>Purpose: This study aims to evaluate the role of high-sensitivity troponin T (hsTnT) as a complementary tool for determining cardiotoxicity in non-Hodgkin lymphoma (NHL) patients receiving cyclophosphamide, doxorubicin, vincristine and prednisone (CHOP) regimen chemotherapy. Methods: We included 35 patients diagnosed with NHL who received CHOP chemotherapy. Left ventricular ejection fraction (LVEF) and hsTnT were measured at two time points: before the first cycle (pre-test) and after the fourth cycle (post-test). The LVEF and hsTnT were analysed using IBM SPSS version 24 through the paired-sample T-test, Wilcoxon signed-rank test, Pearson\u2019s correlation and Spearman\u2019s correlation. Results: There was a significant difference in both LVEF and hsTnT between pre-chemotherapy and post-4th chemotherapy cycles (p = 0.001). However, more contrast difference from the baseline value of hsTnT compared to LVEF could be observed. LVEF did not detect any deterioration in myocardial function. However, 10 out of 35 subjects exhibit hsTnT higher than the 99th percentile of the population (&gt;14 pg\/ml), suggesting that myocardial injury (MI) could be detected. There was no correlation between LVEF and hsTnT (p &gt; 0.05). Conclusion: HsTnT, together with LVEF, could complement each other and offer better coverage for detecting cardiotoxicity during the administration of CHOP in NHL patients. An insignificant correlation between hsTnT and LVEF showed that cardiotoxicity existed in a broad spectrum including cellular damage and functional impairment, as hsTnT represents cellular damage, and LVEF reflects heart functional capacity. <\/jats:p>","DOI":"10.34172\/apb.2022.017","type":"journal-article","created":{"date-parts":[[2021,7,10]],"date-time":"2021-07-10T13:23:57Z","timestamp":1625923437000},"update-policy":"https:\/\/doi.org\/10.34172\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["High Sensitivity Troponin T as Complementary Modality for Determining Doxorubicin Regimen Cardiotoxicity in Non-Hodgkin Lymphoma Patients"],"prefix":"10.34172","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0508-4496","authenticated-orcid":true,"given":"Ami Ashariati","family":"Prayogo","sequence":"first","affiliation":[{"name":"Division of Hematology-Oncology, Department of Internal Medicine, Dr. Soetomo Teaching Hospital, Surabaya, East Java, Indonesia."},{"name":"Department of Internal Medicine, Airlangga University Hospital, Surabaya, East Java, Indonesia."},{"name":"Faculty of Medicine, Airlangga University, Surabaya, East Java, Indonesia."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Satriyo Dwi","family":"Suryantoro","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Airlangga University Hospital, Surabaya, East Java, Indonesia."},{"name":"Faculty of Medicine, Airlangga University, Surabaya, East Java, Indonesia."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Merlyna","family":"Savitri","sequence":"additional","affiliation":[{"name":"Division of Hematology-Oncology, Department of Internal Medicine, Dr. Soetomo Teaching Hospital, Surabaya, East Java, Indonesia."},{"name":"Faculty of Medicine, Airlangga University, Surabaya, East Java, Indonesia."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3867-7773","authenticated-orcid":true,"given":"Winona May","family":"Hendrata","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Airlangga University, Surabaya, East Java, Indonesia."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6463-6265","authenticated-orcid":true,"given":"Andi Yasmin","family":"Wijaya","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Airlangga University, Surabaya, East Java, Indonesia."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Budi Susetyo","family":"Pikir","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Airlangga University, Surabaya, East Java, Indonesia."},{"name":"Department of Cardiology and Vascular Medicine, Dr. Soetomo Teaching Hospital, Surabaya, East Java, Indonesia."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"20123","published-online":{"date-parts":[[2020,10,19]]},"container-title":["Advanced Pharmaceutical Bulletin"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/apb.tbzmed.ac.ir\/Inpress\/apb-28838.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/apb.tbzmed.ac.ir\/Inpress\/apb-28838.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,7,10]],"date-time":"2021-07-10T13:23:57Z","timestamp":1625923437000},"score":1,"resource":{"primary":{"URL":"https:\/\/apb.tbzmed.ac.ir\/Inpress\/apb-28838"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,10,19]]},"references-count":0,"URL":"https:\/\/doi.org\/10.34172\/apb.2022.017","relation":{},"ISSN":["2228-5881","2251-7308"],"issn-type":[{"value":"2228-5881","type":"print"},{"value":"2251-7308","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,10,19]]},"assertion":[{"value":"Tabriz University of Medical Sciences","name":"journal_owner","label":"Journal Owner"},{"value":"Tabriz University of Medical Sciences","name":"journal_publisher","label":"Journal Publisher"},{"value":"2020-04-18","order":1,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-10-17","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-10-19","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}