{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T12:00:49Z","timestamp":1788177649421,"version":"build-2803163510"},"reference-count":0,"publisher":"Maad Rayan Publishing Company","content-domain":{"domain":["apb.tbzmed.ac.ir"],"crossmark-restriction":false},"short-container-title":["Adv Pharm Bull"],"published-print":{"date-parts":[[2021,10,2]]},"abstract":"<jats:p>The concept of immunomodulation was proposed by Edward Jenner, while working on polio vaccine in 1796. Many of the autoimmune diseases such as rheumatoid arthritis, inflammatory bowel diseases, psoriatic arthritis and system lupus erythematosus, viral diseases and, some cancers are characterized with elevated levels of \"immunocytokine\" gene expression, including, tumor necrosis factor-\u03b1, various interleukins, cytotoxic T-cell antigen-4, B-cell activating factor. For the treatment of these diseases, the immunologically-based therapies play the major role. In these lines, the usage of phytomedicines as immunostimulants \/immunosuppressants have been enhanced considerably in last few decades and also used as a prophylactic treatment for various ailments. Phytochemicals such as flavonoids, terpenoids, polysaccharides, lactones, alkaloids, glycosides and saponins present in several plants, have been confirmed to exhibit immunomodulating properties. This review focuses on the traditional plants and their constituents which have been extensively used as immunomodulators. We have also highlighted the mechanism of action (MOA) of these plant constituents related to autophagy and adjuvanticity of drugs.<\/jats:p>","DOI":"10.34172\/apb.2022.074","type":"journal-article","created":{"date-parts":[[2021,10,21]],"date-time":"2021-10-21T07:44:26Z","timestamp":1634802266000},"update-policy":"https:\/\/doi.org\/10.34172\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Plant Derived Immunomodulators; A Critical Review"],"prefix":"10.34172","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2696-4193","authenticated-orcid":true,"given":"Akey Krishna","family":"Swaroop","sequence":"first","affiliation":[{"name":"Department of Pharmaceutical Chemistry, JSS College of Pharmacy, JSS Academy of Higher Education & Research Ooty, Nilgiris, Tamilnadu, India."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chaitanya","family":"Motamarri Venkata Naga Lalitha","sequence":"additional","affiliation":[{"name":"Department of Pharmacognosy, Chitkara College of pharmacy, Chitkara University, Punjab, India."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meena","family":"Shanmugam","sequence":"additional","affiliation":[{"name":"Pharmacy College, Female Sector, Shaqra University, Al Dawadmi, KSA-17431."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gomathy","family":"Subramanian","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Chemistry, JSS College of Pharmacy, JSS Academy of Higher Education & Research Ooty, Nilgiris, Tamilnadu, India."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jawahar","family":"Natarajan","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutics, JSS College of Pharmacy, JSS Academy of Higher Education & Research Ooty, Nilgiris, Tamilnadu, India."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4633-6621","authenticated-orcid":true,"given":"Jubie","family":"Selvaraj","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Chemistry, JSS College of Pharmacy, JSS Academy of Higher Education & Research Ooty, Nilgiris, Tamilnadu, India."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"20123","published-online":{"date-parts":[[2021,10,2]]},"container-title":["Advanced Pharmaceutical Bulletin"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/apb.tbzmed.ac.ir\/Inpress\/apb-32199.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/apb.tbzmed.ac.ir\/Inpress\/apb-32199.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,31]],"date-time":"2022-03-31T06:14:15Z","timestamp":1648707255000},"score":1,"resource":{"primary":{"URL":"https:\/\/apb.tbzmed.ac.ir\/Inpress\/apb-32199"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,10,2]]},"references-count":0,"URL":"https:\/\/doi.org\/10.34172\/apb.2022.074","relation":{},"ISSN":["2228-5881","2251-7308"],"issn-type":[{"value":"2228-5881","type":"print"},{"value":"2251-7308","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,10,2]]},"assertion":[{"value":"Tabriz University of Medical Sciences","name":"journal_owner","label":"Journal Owner"},{"value":"Tabriz University of Medical Sciences","name":"journal_publisher","label":"Journal Publisher"},{"value":"2021-03-05","order":1,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-09-27","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-10-02","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}