{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T22:15:10Z","timestamp":1789769710287,"version":"4.0.1"},"reference-count":0,"publisher":"Maad Rayan Publishing Company","issue":"3","content-domain":{"domain":["apb.tbzmed.ac.ir"],"crossmark-restriction":false},"short-container-title":["Adv Pharm Bull"],"published-print":{"date-parts":[[2023,7,10]]},"abstract":"<jats:p>Periodontal disease is the most common oral disease. This disease can be considered as an inflammatory disease. The immune response to bacteria accumulated in the gum line plays a key role in the pathogenesis of periodontal disease. In addition to immune cells, periodontal ligament cells and gingival epithelial cells are also involved in the pathogenesis of this disease. miRNAs which are small RNA molecules with around 22 nucleotides have a considerable relationship with the immune system affecting a wide range of immunological events. These small molecules are also in relation with periodontium tissues especially periodontal ligament cells. Extensive studies have been performed in recent years on the role of miRNAs in the pathogenesis of periodontal disease. In this review paper, we have reviewed the results of these studies and discussed the role of miRNAs in the immunopathogenesis of periodontal disease comprehensively. miRNAs play an important role in the pathogenesis of periodontal disease and maybe helpful therapeutic targets for the treatment of periodontal disease.<\/jats:p>","DOI":"10.34172\/apb.2023.048","type":"journal-article","created":{"date-parts":[[2022,8,28]],"date-time":"2022-08-28T05:09:05Z","timestamp":1661663345000},"page":"423-434","update-policy":"https:\/\/doi.org\/10.34172\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["MicroRNAs and Periodontal Disease: Helpful Therapeutic Targets?"],"prefix":"10.34172","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4271-0559","authenticated-orcid":true,"given":"Abdolhakim","family":"Palideh","sequence":"first","affiliation":[{"name":"Faculty of Dentistry, Babol University of Medical Sciences, Babol, Iran."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mostafa","family":"Vaghari-Tabari","sequence":"additional","affiliation":[{"name":"Department of Clinical Biochemistry and Laboratory Medicine, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran."},{"name":"Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali","family":"Nosrati Andevari","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Faculty of Medicine, Hormozgan University of Medical Sciences, Bandar Abbas, Iran."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Durdi","family":"Qujeq","sequence":"additional","affiliation":[{"name":"Cellular and Molecular Biology Research Center (CMBRC), Health Research Institute, Babol University of Medical Sciences, Babol, Iran."},{"name":"Department of Clinical Biochemistry, School of Medicine, Babol University of Medical Sciences, Babol, Iran."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zatollah","family":"Asemi","sequence":"additional","affiliation":[{"name":"Research Center for Biochemistry and Nutrition in Metabolic Diseases, Kashan University of Medical Sciences, Kashan, Iran."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Forough","family":"Alemi","sequence":"additional","affiliation":[{"name":"Department of Clinical Biochemistry and Laboratory Medicine, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hemmatollah","family":"Rouhani Otaghsara","sequence":"additional","affiliation":[{"name":"Shahid Rajayee Hospital, Babol University of Medical Sciences, Babol, Iran."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1189-1836","authenticated-orcid":true,"given":"Sona","family":"Rafieyan","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Pathology, School of Dentistry, Zanjan University of Medical Sciences, Zanjan, Iran."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4220-1527","authenticated-orcid":true,"given":"Bahman","family":"Yousefi","sequence":"additional","affiliation":[{"name":"Department of Clinical Biochemistry and Laboratory Medicine, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"20123","published-online":{"date-parts":[[2022,7,2]]},"container-title":["Advanced Pharmaceutical Bulletin"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/apb.tbzmed.ac.ir\/PDF\/apb-13-423.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/apb.tbzmed.ac.ir\/PDF\/apb-13-423.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,7,22]],"date-time":"2023-07-22T02:03:44Z","timestamp":1689991424000},"score":1,"resource":{"primary":{"URL":"https:\/\/apb.tbzmed.ac.ir\/Article\/apb-33028"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,7,2]]},"references-count":0,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2023,7,10]]},"published-print":{"date-parts":[[2023,7,10]]}},"URL":"https:\/\/doi.org\/10.34172\/apb.2023.048","relation":{},"ISSN":["2228-5881","2251-7308"],"issn-type":[{"value":"2228-5881","type":"print"},{"value":"2251-7308","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,7,2]]},"assertion":[{"value":"Tabriz University of Medical Sciences","name":"journal_owner","label":"Journal Owner"},{"value":"Tabriz University of Medical Sciences","name":"journal_publisher","label":"Journal Publisher"},{"value":"2021-08-23","order":1,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-07-01","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-07-02","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}