{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,5]],"date-time":"2026-02-05T09:44:10Z","timestamp":1770284650759,"version":"3.49.0"},"reference-count":23,"publisher":"Maad Rayan Publishing Company","issue":"2","content-domain":{"domain":["bi.tbzmed.ac.ir"],"crossmark-restriction":false},"short-container-title":["Bioimpacts"],"published-print":{"date-parts":[[2020,4,20]]},"abstract":"<jats:p>Introduction: Thalassemia is associated with a genetic decline in the rate of synthesis of one or more types of natural hemoglobin polypeptide chains. One of the major complications in thalassemia patients is alloimmunization, which is antibody production by the patient against transfused red blood cells (RBCs). These RBCs are unknown by the recipient and the formed antibodies against them are called alloantibodies. This study aimed to evaluate the frequency of alloantibodies against RBCs in beta-thalassemia patients referred to Tehran Regional Blood Transfusion Center. Methods: In this study, antibody screening tests (Dia-cell I, II, and III) were performed on 184 thalassemia patients. An identification test by the Dia panel consisting of 11 different O RBCs groups to examine sera with Dia cells (I, II, or III) was performed. Results: In our study, males and females patients comprised 66 (35.87%) and 118 (64.13%), respectively, of whom 116 (63%) had alloimmunization. In addition, 68 thalassemia subjects (37%) lacked alloantibodies. Among 184 patients with beta-thalassemia major, anti-K (Kell system), anti-D, and anti-E (Rhesus system) had the most abundant alloantibody variants with an incidence of 24 (13%), 11 (5.98%), and 10 (5.4%), respectively. Conclusion: Before RBC transfusion, regular RBC antigen phenotypes, as well as problem-solving of alloantibody production by receiving compatible blood for Kell and RH subgroups, are suggested for all cases of transfusion-derived thalassemia.<\/jats:p>","DOI":"10.34172\/bi.2021.20","type":"journal-article","created":{"date-parts":[[2021,5,12]],"date-time":"2021-05-12T12:22:18Z","timestamp":1620822138000},"page":"129-133","update-policy":"https:\/\/doi.org\/10.34172\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Red cell alloantibodies in beta-thalassaemia major patients\u2019 blood referring to the regional blood transfusion center of Tehran, Iran"],"prefix":"10.34172","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5527-1508","authenticated-orcid":true,"given":"Parisa","family":"Ebrahimisadr","sequence":"first","affiliation":[{"name":"Blood Transfusion Research Center, High Institute for Research and Education in Transfusion Medicine, Tehran, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zahra","family":"Bakhshandeh","sequence":"additional","affiliation":[{"name":"Blood Transfusion Research Center, High Institute for Research and Education in Transfusion Medicine, Tehran, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hamidreza","family":"Majidiani","sequence":"additional","affiliation":[{"name":"Departments of Parasitology, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"20123","published-online":{"date-parts":[[2020,4,20]]},"reference":[{"key":"R1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1995.tb24832.x"},{"key":"R2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(17)31822-6"},{"key":"R3","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra050436"},{"key":"R4","doi-asserted-by":"publisher","DOI":"10.5114\/aoms.2010.14473"},{"key":"R5","doi-asserted-by":"publisher","DOI":"10.1016\/S0950-3536(98)80073-5"},{"key":"R6","doi-asserted-by":"publisher","DOI":"10.1016\/S0037-1963(01)90029-0"},{"key":"R7","doi-asserted-by":"publisher","DOI":"10.1186\/cc2847"},{"key":"R8","first-page":"57","article-title":"Evaluation of Transfusion Reactions in Thalassemic Patients Referred to the Tehran Adult Thalssemia Clinic","volume":"16","author":"Azarkeivan A","year":"2008","journal-title":"J Adv Med Biomed Res"},{"key":"R9","doi-asserted-by":"publisher","DOI":"10.1046\/j.1537-2995.1999.39070763.x"},{"key":"R10","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2006.00764.x"},{"key":"R11","doi-asserted-by":"publisher","DOI":"10.1043\/1543-2165(2007)131[708:NCOBT]2.0.CO;2"},{"key":"R12","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.161.2.285"},{"key":"R13","doi-asserted-by":"publisher","DOI":"10.1046\/j.1537-2995.2003.00443.x"},{"key":"R14","doi-asserted-by":"publisher","DOI":"10.1053\/j.seminhematol.2005.04.006"},{"key":"R15","doi-asserted-by":"publisher","DOI":"10.1111\/j.1423-0410.1987.tb02999.x"},{"key":"R16","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3148.1995.tb00210.x"},{"key":"R17","doi-asserted-by":"publisher","DOI":"10.3109\/08880018.2011.568595"},{"key":"R18","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2257.2006.00856.x"},{"key":"R19","doi-asserted-by":"publisher","DOI":"10.1097\/MPH.0b013e3182755f1e"},{"key":"R20","doi-asserted-by":"publisher","DOI":"10.1046\/j.1537-2995.2003.00549.x"},{"key":"R21","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3148.2006.00656.x"},{"key":"R22","first-page":"487","article-title":"Frequency of red cell allo- and autoimmunization in patients with transfusion-dependent beta thalassemia and affecting factors","volume":"56","author":"Kocyigit C","year":"2014","journal-title":"Turk J Pediatr"},{"key":"R23","doi-asserted-by":"publisher","DOI":"10.1016\/j.transci.2017.01.003"}],"container-title":["BioImpacts"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/bi.tbzmed.ac.ir\/PDF\/bi-11-129.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/bi.tbzmed.ac.ir\/PDF\/bi-11-129.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,5,12]],"date-time":"2021-05-12T12:22:21Z","timestamp":1620822141000},"score":1,"resource":{"primary":{"URL":"https:\/\/bi.tbzmed.ac.ir\/Article\/bi-19754"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,4,20]]},"references-count":23,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2021,3]]}},"URL":"https:\/\/doi.org\/10.34172\/bi.2021.20","relation":{},"ISSN":["2228-5660","2228-5652"],"issn-type":[{"value":"2228-5660","type":"print"},{"value":"2228-5652","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,4,20]]},"assertion":[{"value":"Tabriz University of Medical Sciences","name":"journal_owner","label":"Journal Owner"},{"value":"Tabriz University of Medical Sciences","name":"journal_publisher","label":"Journal Publisher"},{"value":"2019-01-17","order":1,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-04-04","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-04-20","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}