{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T17:09:32Z","timestamp":1782407372108,"version":"3.54.5"},"reference-count":0,"publisher":"Maad Rayan Publishing Company","content-domain":{"domain":["bi.tbzmed.ac.ir"],"crossmark-restriction":false},"short-container-title":["Bioimpacts"],"published-print":{"date-parts":[[2021,9,25]]},"abstract":"<jats:p>Introduction: Mesenchymal stromal cells (MSCs) administration is an effective option for the treatment of diabetic foot ulcers (DFUs). However, to date, studies assessing long-term outcomes and evaluating skin parameters after cell-based therapy are lacking. We presented the clinical outcomes of 3 patients, treated for DFUs with the bone marrow MSCs 3 years earlier. Methods: Ultrasound examination was used to compare collagen density and epidermal thickness in areas of healed ulcers in comparison with non-affected skin used as a control. Ultrasound and dermatoscopy were used to exclude neoplasm formation, to assess scar contracture and wound recurrence. Results: In all patients, no ulcer recurrence was detected, which was lower than the expected 60% rate of re-ulceration in diabetic patients in a 3-year period (OD [odds ratio] = 0.095, P = 0.12). No neoplasm formation, no contracture of hypertrophic scar, and adjacent tissue were registered. Collagen ultrasound density was decreased by 57% (P = 0.053) and epidermal thickness was increased by 72% (P = 0.01) in the area of healed ulcers in all patients.  Conclusion: MSCs therapy alone did not result in the complete restoration of the skin parameters within a 3-year period. MSCs may represent important adjuvant to the therapy, however, other novel approaches are required to achieve better results.<\/jats:p>","DOI":"10.34172\/bi.2021.22167","type":"journal-article","created":{"date-parts":[[2021,9,30]],"date-time":"2021-09-30T11:45:19Z","timestamp":1633002319000},"update-policy":"https:\/\/doi.org\/10.34172\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Mesenchymal stromal cells therapy alone does not lead to the complete restoration of the skin parameters in diabetic foot patients within a 3-year follow-up period"],"prefix":"10.34172","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4276-0625","authenticated-orcid":true,"given":"Nadezhda V.","family":"Maksimova","sequence":"first","affiliation":[{"name":"Department of Endocrinology, Sechenov First Moscow State Medical University (Sechenov University), Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna V.","family":"Michenko","sequence":"additional","affiliation":[{"name":"Moscow Scientific and Practical Center of Dermatovenerology and Cosmetology, Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8069-9952","authenticated-orcid":true,"given":"Olga A.","family":"Krasilnikova","sequence":"additional","affiliation":[{"name":"Department of Regenerative Technologies and Biofabrication, National Medical Research Radiological Center, Obninsk, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2888-7999","authenticated-orcid":true,"given":"Ilya D.","family":"Klabukov","sequence":"additional","affiliation":[{"name":"Department of Regenerative Technologies and Biofabrication, National Medical Research Radiological Center, Obninsk, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2782-4179","authenticated-orcid":true,"given":"Igor Yu.","family":"Gadaev","sequence":"additional","affiliation":[{"name":"Chair of Hospital Therapy \u21161, Sechenov First Moscow State Medical University (Sechenov University), Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3574-4013","authenticated-orcid":true,"given":"Michael E.","family":"Krasheninnikov","sequence":"additional","affiliation":[{"name":"Research and Educational Resource Center for Cellular Technologies, Peoples\u2019 Friendship University of Russia, Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pavel A.","family":"Belkov","sequence":"additional","affiliation":[{"name":"Company ANTA-Med, Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0102-5491","authenticated-orcid":true,"given":"Aleksey V.","family":"Lyundup","sequence":"additional","affiliation":[{"name":"Research and Educational Resource Center for Cellular Technologies, Peoples\u2019 Friendship University of Russia, Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"20123","published-online":{"date-parts":[[2021,9,25]]},"container-title":["BioImpacts"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/bi.tbzmed.ac.ir\/Inpress\/bi-22167.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/bi.tbzmed.ac.ir\/Inpress\/bi-22167.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,9,30]],"date-time":"2021-09-30T11:45:20Z","timestamp":1633002320000},"score":1,"resource":{"primary":{"URL":"https:\/\/bi.tbzmed.ac.ir\/Inpress\/bi-22167"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,9,25]]},"references-count":0,"URL":"https:\/\/doi.org\/10.34172\/bi.2021.22167","relation":{},"ISSN":["2228-5660","2228-5652"],"issn-type":[{"value":"2228-5660","type":"print"},{"value":"2228-5652","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,9,25]]},"assertion":[{"value":"Tabriz University of Medical Sciences","name":"journal_owner","label":"Journal Owner"},{"value":"Tabriz University of Medical Sciences","name":"journal_publisher","label":"Journal Publisher"},{"value":"2020-05-26","order":1,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-07-29","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-09-25","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}