{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T19:29:02Z","timestamp":1790710142156,"version":"4.1.0"},"reference-count":207,"publisher":"Maad Rayan Publishing Company","content-domain":{"domain":["bi.tbzmed.ac.ir"],"crossmark-restriction":false},"short-container-title":["Bioimpacts"],"published-print":{"date-parts":[[2026,5,17]]},"abstract":"<jats:p>Breast cancer, a complex and heterogeneous disease marked by uncontrolled cell growth in breast tissue, presents a significant global health challenge due to its high mortality rate. Metastasis, a major driver of cancer progression and mortality, poses a significant challenge in clinical oncology. This complex process involves profound changes in cytoskeletal dynamics and interactions with the extracellular matrix, including integrin-mediated adhesion and the activity of matrix metalloproteinases (MMPs). Circular RNAs (circRNAs) are a type of endogenous non-coding RNA with a covalently closed-loop structure. They serve as critical regulators of gene expression and modulate essential cellular processes, including proliferation, cell cycle control, and invasion. Through intricate interactions with key signaling pathways, including Wnt\/\u03b2-catenin, PI3K\/AKT, TGF-\u03b2\/SMAD, and the MEK-MAPK pathway, circRNAs modulate these processes, particularly epithelial-to-mesenchymal transition (EMT), which is crucial in breast cancer metastasis. Mechanistically, circRNAs activate transcription factors associated with EMT, such as Slug, Snail, Twist, and Zeb. Moreover, circRNAs have emerged as promising clinical biomarkers in breast cancer, offering new opportunities for early diagnosis, prognostic assessment, and the development of targeted therapeutic strategies. In this article, the role of circRNAs in modulating EMT-regulating signaling pathways in the context of breast cancer metastasis will be reviewed.<\/jats:p>","DOI":"10.34172\/bi.32903","type":"journal-article","created":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T11:48:44Z","timestamp":1784634524000},"page":"32903","update-policy":"https:\/\/doi.org\/10.34172\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["The involvement of circular RNAs in breast cancer metastasis: Insight into EMT-related signaling pathways"],"prefix":"10.34172","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-3923-7549","authenticated-orcid":true,"given":"Mehran","family":"Molavand","sequence":"first","affiliation":[{"name":"Department of Clinical Biochemistry and Laboratory Medicine, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran"},{"name":"Student Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9776-5816","authenticated-orcid":true,"given":"Maryam","family":"Majidinia","sequence":"additional","affiliation":[{"name":"Solid Tumor Research Center, Cellular and Molecular Medicine Institute, Urmia University of Medical Sciences, Urmia, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4220-1527","authenticated-orcid":true,"given":"Bahman","family":"Yousefi","sequence":"additional","affiliation":[{"name":"Department of Clinical Biochemistry and Laboratory Medicine, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"20123","published-online":{"date-parts":[[2026,5,17]]},"reference":[{"key":"R1","doi-asserted-by":"publisher","DOI":"10.1053\/j.tvir.2013.12.002"},{"key":"R2","unstructured":"Khan YS, Fakoya AO, Sajjad H. Anatomy, Thorax: Mammary Gland. StatPearls. Treasure Island (FL): StatPearls Publishing Copyright \u00a9 2026, StatPearls Publishing LLC.; 2026."},{"key":"R3","doi-asserted-by":"publisher","DOI":"10.4161\/cbt.10.10.13879"},{"key":"R4","doi-asserted-by":"crossref","unstructured":"Christgen M, Cserni G, Floris G, Marchio C, Djerroudi L, Kreipe H, et al. Lobular Breast Cancer: Histomorphology and Different Concepts of a Special Spectrum of Tumors. Cancers (Basel) 2021; 13. doi:10.3390\/cancers13153695.","DOI":"10.3390\/cancers13153695"},{"key":"R5","doi-asserted-by":"publisher","DOI":"10.4137\/CPath.S31563"},{"key":"R6","doi-asserted-by":"publisher","DOI":"10.1016\/j.soc.2014.03.003"},{"key":"R7","doi-asserted-by":"publisher","DOI":"10.1038\/s41572-019-0111-2"},{"key":"R8","doi-asserted-by":"crossref","unstructured":"Dogan I, Yirgin IK, Ozkurt S, Ib\u0131s K, Vatansever S, Saip P, et al. Outcomes and prognostic factors in patients with HER2-positive metastatic breast cancer with brain metastasis. Journal of Clinical Oncology. 40: e14002\u2013e. doi:10.1200\/JCO.2022.40.16_suppl.e14002.","DOI":"10.1200\/JCO.2022.40.16_suppl.e14002"},{"key":"R9","doi-asserted-by":"crossref","unstructured":"Orr\u00f9 S, Pascariello E, Sotgiu G, Piras D, Saderi L, Muroni MR, et al. Prognostic Role of Androgen Receptor Expression in HER2\u2005+\u2005Breast Carcinoma Subtypes. Biomedicines 2022; 10. doi:10.3390\/biomedicines10010164.","DOI":"10.3390\/biomedicines10010164"},{"key":"R10","doi-asserted-by":"crossref","unstructured":"Bennett C, Carroll C, Wright C, Awad B, Park JM, Farmer M, et al. Breast Cancer Genomics: Primary and Most Common Metastases. Cancers (Basel) 2022; 14. doi:10.3390\/cancers14133046.","DOI":"10.3390\/cancers14133046"},{"key":"R11","doi-asserted-by":"crossref","unstructured":"Fontanella C, Gade S, Von Minckwitz G, Lederer B, Blohmer JU, Costa SD, et al. Prognostic score for Luminal A-like breast cancer patients. Journal of Clinical Oncology. 32: 525\u2013. doi:10.1200\/jco.2014.32.15_suppl.525.","DOI":"10.1200\/jco.2014.32.15_suppl.525"},{"key":"R12","doi-asserted-by":"publisher","DOI":"10.1177\/10732748221106267"},{"key":"R13","doi-asserted-by":"publisher","DOI":"10.1038\/s41698-018-0047-0"},{"key":"R14","doi-asserted-by":"publisher","DOI":"10.1186\/s13058-023-01636-1"},{"key":"R15","doi-asserted-by":"publisher","DOI":"10.7150\/ijbs.21635"},{"key":"R16","doi-asserted-by":"publisher","DOI":"10.1080\/14737140.2025.2519860"},{"key":"R17","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-024-01955-5"},{"key":"R18","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.16375"},{"key":"R19","doi-asserted-by":"publisher","DOI":"10.1038\/s41418-022-00948-7"},{"key":"R20","doi-asserted-by":"publisher","DOI":"10.1007\/s12032-024-02513-3"},{"key":"R21","doi-asserted-by":"crossref","unstructured":"Brodowska A, Grabowska M, Bittel K, Cie\u0107wie\u017c S, Brodowski J, Szczuko M, et al. Estrogen and Progesterone Receptor Immunoexpression in Fallopian Tubes among Postmenopausal Women Based on Time since the Last Menstrual Period. Int J Environ Res Public Health 2021; 18. doi:10.3390\/ijerph18179195.","DOI":"10.3390\/ijerph18179195"},{"key":"R22","doi-asserted-by":"publisher","DOI":"10.2217\/17455057.4.2.151"},{"key":"R23","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdp427"},{"key":"R24","doi-asserted-by":"crossref","unstructured":"Chimento A, De Luca A, Avena P, De Amicis F, Casaburi I, Sirianni R, et al. Estrogen Receptors-Mediated Apoptosis in Hormone-Dependent Cancers. Int J Mol Sci 2022; 23. doi:10.3390\/ijms23031242.","DOI":"10.3390\/ijms23031242"},{"key":"R25","doi-asserted-by":"publisher","DOI":"10.1016\/j.mce.2016.10.017"},{"key":"R26","doi-asserted-by":"publisher","DOI":"10.1016\/j.toxlet.2022.03.003"},{"key":"R27","doi-asserted-by":"publisher","DOI":"10.1289\/ehp4861"},{"key":"R28","doi-asserted-by":"publisher","DOI":"10.1007\/s00204-020-02752-z"},{"key":"R29","doi-asserted-by":"publisher","DOI":"10.1016\/j.envpol.2021.117386"},{"key":"R30","doi-asserted-by":"publisher","DOI":"10.2147\/tacg.S13226"},{"key":"R31","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMsr1501341"},{"key":"R32","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-74250-2"},{"key":"R33","doi-asserted-by":"publisher","DOI":"10.7314\/apjcp.2015.16.6.2177"},{"key":"R34","doi-asserted-by":"publisher","DOI":"10.1038\/nrc1670"},{"key":"R35","doi-asserted-by":"crossref","unstructured":"Park M, Kim D, Ko S, Kim A, Mo K, Yoon H. Breast Cancer Metastasis: Mechanisms and Therapeutic Implications. Int J Mol Sci 2022; 23. doi:10.3390\/ijms23126806.","DOI":"10.3390\/ijms23126806"},{"key":"R36","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2020.113886"},{"key":"R37","doi-asserted-by":"publisher","DOI":"10.3892\/ol.2015.3486"},{"key":"R38","doi-asserted-by":"crossref","unstructured":"Marconi GD, Fonticoli L, Rajan TS, Pierdomenico SD, Trubiani O, Pizzicannella J, et al. Epithelial-Mesenchymal Transition (EMT): The Type-2 EMT in Wound Healing, Tissue Regeneration and Organ Fibrosis. Cells 2021; 10. doi:10.3390\/cells10071587.","DOI":"10.3390\/cells10071587"},{"key":"R39","doi-asserted-by":"publisher","DOI":"10.1038\/nrm3758"},{"key":"R40","doi-asserted-by":"crossref","unstructured":"Usman S, Waseem NH, Nguyen TKN, Mohsin S, Jamal A, Teh MT, et al. Vimentin Is at the Heart of Epithelial Mesenchymal Transition (EMT) Mediated Metastasis. Cancers (Basel) 2021; 13. doi:10.3390\/cancers13194985.","DOI":"10.3390\/cancers13194985"},{"key":"R41","doi-asserted-by":"crossref","unstructured":"Ilnitskaya AS, Litovka NI, Rubtsova SN, Zhitnyak IY, Gloushankova NA. Actin Cytoskeleton Remodeling Accompanied by Redistribution of Adhesion Proteins Drives Migration of Cells in Different EMT States. Cells 2024; 13. doi:10.3390\/cells13090780.","DOI":"10.3390\/cells13090780"},{"key":"R42","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.98.4.1853"},{"key":"R43","doi-asserted-by":"publisher","DOI":"10.1186\/s12964-023-01183-4"},{"key":"R44","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.120907"},{"key":"R45","doi-asserted-by":"publisher","DOI":"10.1017\/erm.2017.6"},{"key":"R46","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2023.12.052"},{"key":"R47","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.Can-09-2123"},{"key":"R48","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-021-25189-z"},{"key":"R49","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M104094200"},{"key":"R50","doi-asserted-by":"publisher","DOI":"10.1007\/s12307-011-0085-4"},{"key":"R51","doi-asserted-by":"crossref","unstructured":"Butturini E, Carcereri de Prati A, Boriero D, Mariotto S. Tumor Dormancy and Interplay with Hypoxic Tumor Microenvironment. Int J Mol Sci 2019; 20. doi:10.3390\/ijms20174305.","DOI":"10.3390\/ijms20174305"},{"key":"R52","doi-asserted-by":"publisher","DOI":"10.1111\/febs.14191"},{"key":"R53","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2018.02977"},{"key":"R54","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2021.709512"},{"key":"R55","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkz311"},{"key":"R56","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2013.08.017"},{"key":"R57","doi-asserted-by":"crossref","unstructured":"Papatsirou M, Artemaki PI, Karousi P, Scorilas A, Kontos CK. Circular RNAs: Emerging Regulators of the Major Signaling Pathways Involved in Cancer Progression. Cancers (Basel) 2021; 13. doi:10.3390\/cancers13112744.","DOI":"10.3390\/cancers13112744"},{"key":"R58","doi-asserted-by":"publisher","DOI":"10.1186\/s12935-021-02017-4"},{"key":"R59","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbamcr.2020.118876"},{"key":"R60","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2020.105143"},{"key":"R61","doi-asserted-by":"publisher","DOI":"10.1016\/j.bdq.2019.100085"},{"key":"R62","doi-asserted-by":"publisher","DOI":"10.15252\/embr.202052072"},{"key":"R63","doi-asserted-by":"publisher","DOI":"10.1111\/febs.70012"},{"key":"R64","doi-asserted-by":"publisher","DOI":"10.1002\/cpz1.181"},{"key":"R65","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4939-7562-4_10"},{"key":"R66","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkv1458"},{"key":"R67","doi-asserted-by":"publisher","DOI":"10.1038\/s41592-022-01487-2"},{"key":"R68","doi-asserted-by":"publisher","DOI":"10.1186\/s12915-023-01804-x"},{"key":"R69","doi-asserted-by":"publisher","DOI":"10.55705\/cmbr.2025.460043.1248"},{"key":"R70","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-021-82057-y"},{"key":"R71","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.919145"},{"key":"R72","doi-asserted-by":"publisher","DOI":"10.3389\/fgene.2024.1417415"},{"key":"R73","doi-asserted-by":"crossref","unstructured":"Savagner P, Gilles C, Newgreen DF, Sato H, Thompson EW. Matrix metalloproteases and epithelial-to-mesenchymal transition: implications for carcinoma metastasis. Rise Fall Epithelial Phenotype 2005; 297-315.","DOI":"10.1007\/0-387-28671-3_20"},{"key":"R74","doi-asserted-by":"crossref","unstructured":"Datta A, Deng S, Gopal V, Yap KC, Halim CE, Lye ML, et al. Cytoskeletal Dynamics in Epithelial-Mesenchymal Transition: Insights into Therapeutic Targets for Cancer Metastasis. Cancers (Basel) 2021; 13. doi:10.3390\/cancers13081882.","DOI":"10.3390\/cancers13081882"},{"key":"R75","doi-asserted-by":"publisher","DOI":"10.1186\/s12964-021-00713-2"},{"key":"R76","doi-asserted-by":"publisher","DOI":"10.1016\/j.ceb.2024.102325"},{"key":"R77","doi-asserted-by":"publisher","DOI":"10.1007\/s11033-026-11431-8"},{"key":"R78","doi-asserted-by":"publisher","DOI":"10.1177\/172460080902400106"},{"key":"R79","doi-asserted-by":"publisher","DOI":"10.1098\/rsob.130001"},{"key":"R80","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-023-48279-y"},{"key":"R81","doi-asserted-by":"crossref","unstructured":"Fu A, Yao B, Dong T, Chen Y, Yao J, Liu Y, et al. Tumor-resident intracellular microbiota promotes metastatic colonization in breast cancer. Cell 2022; 185: 1356-1372.e26. doi:10.1016\/j.cell.2022.02.027.","DOI":"10.1016\/j.cell.2022.02.027"},{"key":"R82","unstructured":"Klub\u00ed\u010dkov\u00e1 N. The role of microtubule dynamics in cancer metastasis [thesis]. Univerzita Karlova, P\u0159\u00edrodov\u011bdeck\u00e1 fakulta; 2020."},{"key":"R83","doi-asserted-by":"publisher","DOI":"10.1177\/1010428317705501"},{"key":"R84","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2022.791272"},{"key":"R85","doi-asserted-by":"crossref","unstructured":"Heldin CH, Moustakas A. Signaling Receptors for TGF-\u03b2 Family Members. Cold Spring Harb Perspect Biol 2016; 8. doi:10.1101\/cshperspect.a022053.","DOI":"10.1101\/cshperspect.a022053"},{"key":"R86","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M116.773085"},{"key":"R87","doi-asserted-by":"crossref","unstructured":"Hata A, Chen YG. TGF-\u03b2 Signaling from Receptors to Smads. Cold Spring Harb Perspect Biol 2016; 8. doi:10.1101\/cshperspect.a022061.","DOI":"10.1101\/cshperspect.a022061"},{"key":"R88","doi-asserted-by":"crossref","unstructured":"Howe PH. CHAPTER 49 - Transforming growth factor \u03b2. In: Thomson AW, MT Lotze, editors. The Cytokine Handbook (Fourth Edition). London: Academic Press. 2003. p. 1119-52d.","DOI":"10.1016\/B978-012689663-3\/50053-3"},{"key":"R89","doi-asserted-by":"publisher","DOI":"10.4161\/cc.20546"},{"key":"R90","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.114.24.4359"},{"key":"R91","doi-asserted-by":"publisher","DOI":"10.1093\/emboj\/16.17.5353"},{"key":"R92","doi-asserted-by":"publisher","DOI":"10.1016\/j.cytogfr.2009.10.010"},{"key":"R93","doi-asserted-by":"publisher","DOI":"10.4161\/cc.9.12.12050"},{"key":"R94","doi-asserted-by":"publisher","DOI":"10.1186\/s12943-018-0914-x"},{"key":"R95","first-page":"3592\u20138","article-title":"USF1 prompt melanoma through upregulating TGF-\u03b2 signaling pathway","volume":"20","author":"Ren YQ","year":"2016","journal-title":"Eur Rev Med Pharmacol Sci"},{"key":"R96","doi-asserted-by":"publisher","DOI":"10.1139\/bcb-2020-0219"},{"key":"R97","doi-asserted-by":"publisher","DOI":"10.1016\/j.reth.2022.02.003"},{"key":"R98","doi-asserted-by":"publisher","DOI":"10.2147\/ott.S239789"},{"key":"R99","doi-asserted-by":"publisher","DOI":"10.1186\/s12943-018-0889-7"},{"key":"R100","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymthe.2021.01.031"},{"key":"R101","doi-asserted-by":"publisher","DOI":"10.1186\/s12943-022-01495-y"},{"key":"R102","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-021-00762-6"},{"key":"R103","doi-asserted-by":"publisher","DOI":"10.1002\/iub.70074"},{"key":"R104","doi-asserted-by":"publisher","DOI":"10.1016\/s1359-6101(00)00011-3"},{"key":"R105","doi-asserted-by":"publisher","DOI":"10.1016\/j.devcel.2009.06.016"},{"key":"R106","doi-asserted-by":"crossref","unstructured":"Marineau A, Khan KA, Servant MJ. Roles of GSK-3 and \u03b2-Catenin in Antiviral Innate Immune Sensing of Nucleic Acids. Cells 2020; 9. doi:10.3390\/cells9040897.","DOI":"10.3390\/cells9040897"},{"key":"R107","doi-asserted-by":"crossref","unstructured":"Shishido A, Miyo M, Oishi K, Nishiyama N, Wu M, Yamamoto H, et al. The Relationship between LRP6 and Wnt\/\u03b2-Catenin Pathway in Colorectal and Esophageal Cancer. Life (Basel) 2023; 13. doi:10.3390\/life13030615.","DOI":"10.3390\/life13030615"},{"key":"R108","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2021.670960"},{"key":"R109","doi-asserted-by":"publisher","DOI":"10.1016\/j.prp.2022.154185"},{"key":"R110","doi-asserted-by":"publisher","DOI":"10.4149\/neo_2018_180710N460"},{"key":"R111","doi-asserted-by":"publisher","DOI":"10.1080\/15384101.2020.1815147"},{"key":"R112","doi-asserted-by":"publisher","DOI":"10.26355\/eurrev_201906_18198"},{"key":"R113","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-021-03680-1"},{"key":"R114","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymthe.2021.08.026"},{"key":"R115","doi-asserted-by":"publisher","DOI":"10.1186\/s12935-022-02657-0"},{"key":"R116","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-021-03794-6"},{"key":"R117","doi-asserted-by":"publisher","DOI":"10.1080\/21691401.2019.1669620"},{"key":"R118","doi-asserted-by":"publisher","DOI":"10.1186\/s12864-021-07880-z"},{"key":"R119","doi-asserted-by":"publisher","DOI":"10.26355\/eurrev_201904_17700"},{"key":"R120","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2019.116692"},{"key":"R121","doi-asserted-by":"publisher","DOI":"10.1016\/j.ctrv.2003.07.007"},{"key":"R122","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2017.04.001"},{"key":"R123","doi-asserted-by":"publisher","DOI":"10.3892\/ol.2013.1552"},{"key":"R124","doi-asserted-by":"publisher","DOI":"10.18632\/aging.100853"},{"key":"R125","doi-asserted-by":"publisher","DOI":"10.3233\/cbm-182293"},{"key":"R126","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-022-05246-1"},{"key":"R127","doi-asserted-by":"publisher","DOI":"10.1111\/cas.14589"},{"key":"R128","doi-asserted-by":"publisher","DOI":"10.1186\/s12943-019-0946-x"},{"key":"R129","doi-asserted-by":"publisher","DOI":"10.3892\/ijmm.2014.1638"},{"key":"R130","doi-asserted-by":"publisher","DOI":"10.1080\/21655979.2021.2008738"},{"key":"R131","doi-asserted-by":"publisher","DOI":"10.1186\/s12935-021-01902-2"},{"key":"R132","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygeno.2020.12.006"},{"key":"R133","doi-asserted-by":"publisher","DOI":"10.1016\/j.gene.2020.145113"},{"key":"R134","doi-asserted-by":"publisher","DOI":"10.18632\/aging.203996"},{"key":"R135","doi-asserted-by":"publisher","DOI":"10.1016\/j.cellsig.2022.110494"},{"key":"R136","doi-asserted-by":"publisher","DOI":"10.1186\/s12943-021-01332-8"},{"key":"R137","doi-asserted-by":"publisher","DOI":"10.3892\/ol.2021.12680"},{"key":"R138","doi-asserted-by":"publisher","DOI":"10.1091\/mbc.01-11-0552"},{"key":"R139","doi-asserted-by":"publisher","DOI":"10.1016\/j.febslet.2014.06.025"},{"key":"R140","doi-asserted-by":"publisher","DOI":"10.1186\/2045-3701-1-42"},{"key":"R141","doi-asserted-by":"publisher","DOI":"10.1016\/j.cyto.2020.155287"},{"key":"R142","doi-asserted-by":"publisher","DOI":"10.3390\/genes10120961"},{"key":"R143","doi-asserted-by":"publisher","DOI":"10.1016\/j.heliyon.2024.e28785"},{"key":"R144","doi-asserted-by":"publisher","DOI":"10.3892\/or.2020.7807"},{"key":"R145","doi-asserted-by":"publisher","DOI":"10.18632\/aging.102539"},{"key":"R146","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2021.649242"},{"key":"R147","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-023-06085-4"},{"key":"R148","doi-asserted-by":"publisher","DOI":"10.21037\/tlcr.2019.11.04"},{"key":"R149","doi-asserted-by":"publisher","DOI":"10.1186\/s12943-018-0935-5"},{"key":"R150","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-020-2607-9"},{"key":"R151","doi-asserted-by":"publisher","DOI":"10.1016\/j.heliyon.2024.e33195"},{"key":"R152","doi-asserted-by":"publisher","DOI":"10.3892\/ol.2020.11394"},{"key":"R153","doi-asserted-by":"publisher","DOI":"10.1186\/s12967-021-03133-5"},{"key":"R154","doi-asserted-by":"publisher","DOI":"10.1186\/s12943-020-01183-9"},{"key":"R155","doi-asserted-by":"publisher","DOI":"10.1111\/pin.13011"},{"key":"R156","doi-asserted-by":"publisher","DOI":"10.2147\/ott.S150678"},{"key":"R157","doi-asserted-by":"publisher","DOI":"10.1016\/j.hbpd.2019.03.003"},{"key":"R158","doi-asserted-by":"publisher","DOI":"10.1080\/15384101.2022.2087280"},{"key":"R159","doi-asserted-by":"publisher","DOI":"10.1093\/toxsci\/kfad060"},{"key":"R160","doi-asserted-by":"publisher","DOI":"10.1186\/s12935-023-03026-1"},{"key":"R161","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2020.00605"},{"key":"R162","first-page":"2554\u201369","article-title":"CircAPLP2 regulates the proliferation and metastasis of colorectal cancer by targeting miR-101-3p to activate the Notch signalling pathway","volume":"12","author":"Wu HB","year":"2020","journal-title":"Am J Transl Res"},{"key":"R163","doi-asserted-by":"publisher","DOI":"10.2147\/ott.S280434"},{"key":"R164","doi-asserted-by":"publisher","DOI":"10.1007\/s13577-022-00835-w"},{"key":"R165","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-020-2441-0"},{"key":"R166","doi-asserted-by":"publisher","DOI":"10.1007\/s11010-020-03886-5"},{"key":"R167","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2019.117179"},{"key":"R168","doi-asserted-by":"publisher","DOI":"10.3892\/mmr.2019.9965"},{"key":"R169","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymthe.2020.03.002"},{"key":"R170","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2018.08.030"},{"key":"R171","doi-asserted-by":"publisher","DOI":"10.1002\/jcb.28822"},{"key":"R172","doi-asserted-by":"publisher","DOI":"10.2217\/epi-2017-0167"},{"key":"R173","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2022.108530"},{"key":"R174","doi-asserted-by":"publisher","DOI":"10.1186\/s12935-022-02686-9"},{"key":"R175","doi-asserted-by":"publisher","DOI":"10.1186\/s13062-023-00397-3"},{"key":"R176","doi-asserted-by":"publisher","DOI":"10.1007\/s12026-021-09237-w"},{"key":"R177","doi-asserted-by":"crossref","unstructured":"Dong LF, Chen FF, Fan YF, Zhang K, Chen HH. circ-0000512 inhibits PD-L1 ubiquitination through sponging miR-622\/CMTM6 axis to promote triple-negative breast cancer and immune escape. J Immunother Cancer 2023; 11. doi:10.1136\/jitc-2022-005461.","DOI":"10.1136\/jitc-2022-005461"},{"key":"R178","doi-asserted-by":"publisher","DOI":"10.1007\/s00262-024-03705-6"},{"key":"R179","doi-asserted-by":"publisher","DOI":"10.1038\/s41420-024-02197-8"},{"key":"R180","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.med.49.1.407"},{"key":"R181","doi-asserted-by":"publisher","DOI":"10.1111\/jcmm.14875"},{"key":"R182","doi-asserted-by":"publisher","DOI":"10.1007\/s12282-024-01574-6"},{"key":"R183","doi-asserted-by":"publisher","DOI":"10.1186\/s12943-019-1002-6"},{"key":"R184","doi-asserted-by":"publisher","DOI":"10.3389\/fgene.2022.823238"},{"key":"R185","doi-asserted-by":"crossref","unstructured":"De Palma FD, Salvatore F, Pol JG, Kroemer G, Maiuri MC. Circular RNAs as Potential Biomarkers in Breast Cancer. Biomedicines [serial on the Internet] 2022; 10(3). doi:10.3390\/biomedicines10030725.","DOI":"10.3390\/biomedicines10030725"},{"key":"R186","doi-asserted-by":"publisher","DOI":"10.1186\/s12935-021-02015-6"},{"key":"R187","doi-asserted-by":"crossref","unstructured":"Wang L, Li X, Wang D, Feng H, Ma F, Cao J, et al. Identification of circular RNAs hsa-circ-000696 as a novel biomarker for breast cancer. Research Square 2019. doi:10.21203\/rs.2.13471\/v1.","DOI":"10.21203\/rs.2.13471\/v1"},{"key":"R188","doi-asserted-by":"publisher","DOI":"10.2147\/ijgm.S319801"},{"key":"R189","doi-asserted-by":"publisher","DOI":"10.1016\/j.cca.2017.10.011"},{"key":"R190","doi-asserted-by":"publisher","DOI":"10.3390\/cancers14133280"},{"key":"R191","doi-asserted-by":"publisher","DOI":"10.1177\/15330338251328500"},{"key":"R192","doi-asserted-by":"publisher","DOI":"10.7150\/thno.24106"},{"key":"R193","doi-asserted-by":"publisher","DOI":"10.1002\/jcla.22980"},{"key":"R194","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2021.691317"},{"key":"R195","doi-asserted-by":"publisher","DOI":"10.1002\/jcla.24008"},{"key":"R196","doi-asserted-by":"publisher","DOI":"10.1002\/tox.23509"},{"key":"R197","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2021.639961"},{"key":"R198","doi-asserted-by":"publisher","DOI":"10.1016\/j.tranon.2021.101045"},{"key":"R199","doi-asserted-by":"publisher","DOI":"10.1111\/jcmm.14171"},{"key":"R200","doi-asserted-by":"publisher","DOI":"10.15252\/embj.2022112408"},{"key":"R201","doi-asserted-by":"publisher","DOI":"10.20892\/j.issn.2095-3941.2020.0275"},{"key":"R202","doi-asserted-by":"publisher","DOI":"10.1111\/1759-7714.13603"},{"key":"R203","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-023-06006-5"},{"key":"R204","doi-asserted-by":"publisher","DOI":"10.1111\/1759-7714.13475"},{"key":"R205","doi-asserted-by":"publisher","DOI":"10.1177\/15330338241252423"},{"key":"R206","doi-asserted-by":"publisher","DOI":"10.2147\/OTT.S201310"},{"key":"R207","doi-asserted-by":"publisher","DOI":"10.1186\/s12864-022-08558-w"}],"container-title":["BioImpacts"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/bi.tbzmed.ac.ir\/PDF\/bi-16-32903.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/bi.tbzmed.ac.ir\/PDF\/bi-16-32903.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T11:48:54Z","timestamp":1784634534000},"score":1,"resource":{"primary":{"URL":"https:\/\/bi.tbzmed.ac.ir\/Article\/bi-32903"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,17]]},"references-count":207,"URL":"https:\/\/doi.org\/10.34172\/bi.32903","relation":{},"ISSN":["2228-5652","2228-5660"],"issn-type":[{"value":"2228-5652","type":"print"},{"value":"2228-5660","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5,17]]},"assertion":[{"value":"Tabriz University of Medical Sciences","name":"journal_owner","label":"Journal Owner"},{"value":"Tabriz University of Medical Sciences","name":"journal_publisher","label":"Journal Publisher"},{"value":"2025-10-05","order":1,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-12-30","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-05-17","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}