{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T02:05:38Z","timestamp":1789524338068,"version":"build-2803163510"},"reference-count":52,"publisher":"Maad Rayan Publishing Company","issue":"1","content-domain":{"domain":["hpp.tbzmed.ac.ir"],"crossmark-restriction":false},"short-container-title":["Health Promot Perspect"],"abstract":"<jats:p>Background: The present clinical trial aimed to examine whether adherence to Dietary Approaches to Stop Hypertension (DASH) diet could improve lipid profile, the Pro-oxidant-antioxidant balance (PAB) as well as liver function in obese adults with non-alcoholic fatty liver disease (NAFLD). Methods: Sixty two patients with NAFLD were equally allocated into either DASH or low-calorie diet (LCD) group for 8 weeks. The primary and secondary outcomes were determined before and after the trial. Results: Forty patients completed the trial. Significant within group differences were found in dietary saturated fat, selenium, vitamins A and E as well as body weight and body mass index (BMI) and waist circumference (WC) after the intervention (P&lt;0.05). DASH diet showed greater significant change in systolic and diastolic blood pressure without significant differences between the groups after 8 weeks. Apart from serum high-density lipoprotein cholesterol (HDL-C) and triglyceride\/HDL-C, greater reductions were found not only in serum lipids and atherogenic indices (P&lt;0.05) but also in serum aspartate aminotransferase (AST), AST to platelet ratio index (APRI) and lipid accumulation product (LAP) in DASH group in comparison to control group (P=0.008, P=0.019 and P=0.003, respectively). Nevertheless, there was not any difference in PAB level between the groups. Furthermore, adherence to DASH diet was more effective in alleviating liver steatosis compared with usual LCD (P=0.012). Conclusion: Adherence to DASH diet appears to be more effective in improving obesity, atherogenic and liver steatosis biomarkers but not oxidative stress (OS) than usual LCD.<\/jats:p>","DOI":"10.34172\/hpp.2023.10","type":"journal-article","created":{"date-parts":[[2023,6,10]],"date-time":"2023-06-10T06:25:02Z","timestamp":1686378302000},"page":"77-87","update-policy":"https:\/\/doi.org\/10.34172\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["The effect of DASH diet on atherogenic indices, pro-oxidant-antioxidant balance, and liver steatosis in obese adults with non-alcoholic fatty liver disease: A double-blind controlled randomized clinical trial"],"prefix":"10.34172","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-0096-087X","authenticated-orcid":true,"given":"Taghi","family":"Badali","sequence":"first","affiliation":[{"name":"Student Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0962-5571","authenticated-orcid":true,"given":"Sara","family":"Arefhosseini","sequence":"additional","affiliation":[{"name":"Student Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Farnaz","family":"Rooholahzadegan","sequence":"additional","affiliation":[{"name":"Student Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4795-1757","authenticated-orcid":true,"given":"Helda","family":"Tutunchi","sequence":"additional","affiliation":[{"name":"Endocrine Research Center, Tabriz University of Medical Sciences, Tabriz, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0311-1289","authenticated-orcid":true,"given":"Mehrangiz","family":"Ebrahimi-Mameghani","sequence":"additional","affiliation":[{"name":"Nutrition Research Center, Department of Biochemistry and Diet Therapy, Faculty of Nutrition and Food Sciences, Tabriz University of Medical Sciences, Tabriz, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"20123","published-online":{"date-parts":[[2023,4,30]]},"reference":[{"key":"R1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v20.i27.9050"},{"key":"R2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms20081948"},{"key":"R3","doi-asserted-by":"publisher","DOI":"10.1155\/2021\/6613827"},{"key":"R4","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2015.04.004"},{"key":"R5","doi-asserted-by":"publisher","DOI":"10.1002\/hep.30251"},{"key":"R6","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v16.i38.4773"},{"key":"R7","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2005.41500.x"},{"key":"R8","doi-asserted-by":"publisher","DOI":"10.1002\/hep.31420"},{"key":"R9","doi-asserted-by":"publisher","DOI":"10.1016\/j.cccn.2004.12.022"},{"key":"R10","doi-asserted-by":"publisher","DOI":"10.1097\/01.mcg.0000212608.59090.08"},{"key":"R11","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinbiochem.2006.10.017"},{"key":"R12","doi-asserted-by":"publisher","DOI":"10.1159\/000443344"},{"key":"R13","doi-asserted-by":"publisher","DOI":"10.1002\/hep.29367"},{"key":"R14","doi-asserted-by":"publisher","DOI":"10.3390\/nu12123860"},{"key":"R15","doi-asserted-by":"publisher","DOI":"10.1016\/s0002-8223(99)00414-9"},{"key":"R16","doi-asserted-by":"publisher","DOI":"10.1016\/s0895-7061(99)00284-8"},{"key":"R17","doi-asserted-by":"publisher","DOI":"10.1053\/jada.2003.50065"},{"key":"R18","doi-asserted-by":"crossref","unstructured":"Arjmand G, Abbas-Zadeh M, Fardaei M, Eftekhari MH. Randomized controlled trial effect of short-term MIND diet intervention on hunger hormones, anthropometric parameters, and brain structures in middle-aged obese women. medRxiv [Preprint]. July 7, 2020. Available from: https:\/\/www.medrxiv.org\/content\/10.1101\/2020.06.28.20142018v1.","DOI":"10.1101\/2020.06.28.20142018"},{"key":"R19","doi-asserted-by":"publisher","DOI":"10.3390\/nu12030825"},{"key":"R20","doi-asserted-by":"publisher","DOI":"10.1093\/cdn\/nzaa024"},{"key":"R21","doi-asserted-by":"publisher","DOI":"10.1111\/liv.12990"},{"key":"R22","doi-asserted-by":"publisher","DOI":"10.1007\/s40200-022-01028-w"},{"key":"R23","doi-asserted-by":"publisher","DOI":"10.2174\/0929867328666210825111350"},{"key":"R24","doi-asserted-by":"publisher","DOI":"10.1111\/obr.12391"},{"key":"R25","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2007.01526.x"},{"key":"R26","first-page":"124","article-title":"Pro-oxidant antioxidant balance in patients with non-alcoholic fatty liver disease","volume":"12","author":"Nobakht Motlagh Ghoochani BF","year":"2019","journal-title":"Gastroenterol Hepatol Bed Bench"},{"key":"R27","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/51.2.241"},{"key":"R28","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/137.11.2443"},{"key":"R29","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwr148"},{"key":"R30","doi-asserted-by":"publisher","DOI":"10.1056\/nejm200101043440101"},{"key":"R31","unstructured":"IPAQ Research Committee. Guidelines for Data Processing Analysis of the International Physical Activity Questionnaire (IPAQ)-Short and Long Forms. 2005. Available from: http:\/\/www.ipaq.ki.se\/scoring.pdf."},{"key":"R32","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1016\/S1665-2681(19)31836-8","article-title":"AST to platelet ratio index (APRI) for the noninvasive evaluation of liver fibrosis","volume":"7","author":"Loaeza-del-Castillo A","year":"2008","journal-title":"Ann Hepatol"},{"key":"R33","doi-asserted-by":"publisher","DOI":"10.3803\/EnM.2014.29.4.443"},{"key":"R34","doi-asserted-by":"publisher","DOI":"10.3390\/nu12010102"},{"key":"R35","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-006-0198-3"},{"key":"R36","doi-asserted-by":"publisher","DOI":"10.3945\/ajcn.115.124677"},{"key":"R37","doi-asserted-by":"publisher","DOI":"10.1111\/j.1753-4887.2001.tb07001.x"},{"key":"R38","doi-asserted-by":"publisher","DOI":"10.2174\/1573402115666191007144608"},{"key":"R39","doi-asserted-by":"publisher","DOI":"10.3390\/nu11020338"},{"key":"R40","doi-asserted-by":"publisher","DOI":"10.1016\/j.obmed.2020.100272"},{"key":"R41","doi-asserted-by":"publisher","DOI":"10.1155\/2021\/4963641"},{"key":"R42","doi-asserted-by":"publisher","DOI":"10.1016\/j.dsx.2021.102332"},{"key":"R43","doi-asserted-by":"publisher","DOI":"10.1161\/01.hyp.0000053450.19998.11"},{"key":"R44","doi-asserted-by":"publisher","DOI":"10.1017\/s0954422418000148"},{"key":"R45","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-021-97686-6"},{"key":"R46","doi-asserted-by":"publisher","DOI":"10.1515\/dmpt-2018-0040"},{"key":"R47","doi-asserted-by":"publisher","DOI":"10.3390\/nu12061659"},{"key":"R48","doi-asserted-by":"publisher","DOI":"10.1016\/j.dsx.2020.10.031"},{"key":"R49","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-022-06035-8"},{"key":"R50","doi-asserted-by":"publisher","DOI":"10.1186\/s12937-020-00631-y"},{"key":"R51","doi-asserted-by":"publisher","DOI":"10.1017\/s1368980019002568"},{"key":"R52","doi-asserted-by":"publisher","DOI":"10.1017\/s0007114521004839"}],"container-title":["Health Promotion Perspectives"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/hpp.tbzmed.ac.ir\/PDF\/hpp-13-77.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/hpp.tbzmed.ac.ir\/PDF\/hpp-13-77.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,6,10]],"date-time":"2023-06-10T06:25:09Z","timestamp":1686378309000},"score":1,"resource":{"primary":{"URL":"https:\/\/hpp.tbzmed.ac.ir\/Article\/hpp-40834"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,4,30]]},"references-count":52,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2023,4,30]]}},"URL":"https:\/\/doi.org\/10.34172\/hpp.2023.10","relation":{},"ISSN":["2228-6497"],"issn-type":[{"value":"2228-6497","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,4,30]]},"assertion":[{"value":"Tabriz University of Medical Sciences","name":"journal_owner","label":"Journal Owner"},{"value":"Tabriz University of Medical Sciences","name":"journal_publisher","label":"Journal Publisher"},{"value":"2022-10-13","order":1,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-01-24","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-04-30","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}