{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T19:15:08Z","timestamp":1784142908820,"version":"3.55.0"},"reference-count":0,"publisher":"Maad Rayan Publishing Company","issue":"4","content-domain":{"domain":["hpp.tbzmed.ac.ir"],"crossmark-restriction":false},"short-container-title":["Health Promot Perspect"],"abstract":"<jats:p>Background: Sodium-glucose cotransporter-2 (SGLT-2) acts as a key element in the reabsorption of glucose in the kidney. Currently, SGLT-2 inhibitors are FDA-approved for the treatment of type 2 diabetes. It is suggested that the mechanism of action may operate in the treatment of type 1 diabetes mellitus (T1DM), as well. This study aimed to evaluate the application of empagliflozin as an adjunctive to insulin in patients with T1D. Methods: In this double-blind placebo-controlled randomized clinical study, 60 type 1 diabetic patients were randomly assigned to have either once-daily empagliflozin 10 mg or placebo, as an addition to insulin for 12 weeks. The hemoglobin A1C, fasting blood sugar (FBS), 2-hour post-prandial blood sugar, and anthropometric indices were measured before and after 12 weeks intervention. Results: After 12 weeks, empagliflozin resulted in significant reductions of hemoglobin A1C -0.18 (95% CI: -0.37, 0.005, P=0.009), FBS \u20132.60 mg\/dL (95% CI: -6.48, 1.28, P=0.035), 2-hour post-prandial blood sugar -22.56 mg\/dL (95% CI: -35.15, 8.97, P&lt;0.0001), and total daily insulin dose \u20137.6 units (95% CI: -12.4, 2.8, P=0.003). Furthermore, empagliflozin reduced body mass index (BMI) by -0.560 kg (95% CI: -0.640, 1.46, P&lt;0.0001). Empagliflozin was well tolerated in the patients. Also, no case of hypoglycemia, genital and urinary infections, or diabetic ketoacidosis (DKA) was reported. Conclusion: The present study supported the use of empagliflozin alongside insulin as a treatment option for individuals with T1D. Trial Registration: http:\/\/ www.irct.ir, identifier: irct20130610013612N12, Registration date: 12\/9\/2022). <\/jats:p>","DOI":"10.34172\/hpp.42486","type":"journal-article","created":{"date-parts":[[2025,2,4]],"date-time":"2025-02-04T07:17:35Z","timestamp":1738653455000},"page":"380-387","update-policy":"https:\/\/doi.org\/10.34172\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["The effects of empagliflozin in patients with type 1 diabetes: Results of a 12-week, double-blind, randomized, placebo-controlled clinical trial"],"prefix":"10.34172","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9831-933X","authenticated-orcid":true,"given":"Mostafa","family":"Najafipour","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, Faculty of Medicine, Azad Ardabil University of Medical Sciences, Ardabil, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1950-0702","authenticated-orcid":true,"given":"Farzad","family":"Najafipour","sequence":"additional","affiliation":[{"name":"Endocrine Research Center, Tabriz University of Medical Sciences, Tabriz, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alireza","family":"Ostadrahimi","sequence":"additional","affiliation":[{"name":"Nutrition Research Center, Department of Clinical Nutrition, Faculty of Nutrition and Food Science, Tabriz University of Medical Sciences, Tabriz, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maryam","family":"Ghavami","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Faculty of Medicine, Azad Ardabil University of Medical Sciences, Ardabil, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zohreh","family":"Razaghi","sequence":"additional","affiliation":[{"name":"Endocrine Research Center, Tabriz University of Medical Sciences, Tabriz, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helda","family":"Tutunchi","sequence":"additional","affiliation":[{"name":"Endocrine Research Center, Tabriz University of Medical Sciences, Tabriz, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2563-8193","authenticated-orcid":true,"given":"Naimeh","family":"Mesri Alamdari","sequence":"additional","affiliation":[{"name":"Endocrine Research Center, Tabriz University of Medical Sciences, Tabriz, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"20123","published-online":{"date-parts":[[2024,12,30]]},"container-title":["Health Promotion Perspectives"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/hpp.tbzmed.ac.ir\/PDF\/hpp-14-380.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/hpp.tbzmed.ac.ir\/PDF\/hpp-14-380.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,4]],"date-time":"2025-02-04T07:17:36Z","timestamp":1738653456000},"score":1,"resource":{"primary":{"URL":"https:\/\/hpp.tbzmed.ac.ir\/Article\/hpp-42486"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12,30]]},"references-count":0,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2024,12,30]]}},"URL":"https:\/\/doi.org\/10.34172\/hpp.42486","relation":{},"ISSN":["2228-6497"],"issn-type":[{"value":"2228-6497","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,12,30]]},"assertion":[{"value":"Tabriz University of Medical Sciences","name":"journal_owner","label":"Journal Owner"},{"value":"Tabriz University of Medical Sciences","name":"journal_publisher","label":"Journal Publisher"},{"value":"2024-09-04","order":1,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-11-08","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-12-30","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}