{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,14]],"date-time":"2025-12-14T16:43:21Z","timestamp":1765730601572,"version":"3.48.0"},"reference-count":20,"publisher":"Maad Rayan Publishing Company","issue":"4","content-domain":{"domain":["japid.tbzmed.ac.ir"],"crossmark-restriction":false},"short-container-title":["J Adv Periodontol Implant Dent"],"abstract":"<jats:p>Background. Suture materials in the oral cavity can promote bacterial adhesion and contamination. While antimicrobial-coated sutures are effective, their use is limited by cost, availability, and toxicity. Platelet-rich fibrin (PRF) derivatives have shown antimicrobial activity against periodontal pathogens. This study compared the antimicrobial efficacy of sutures soaked in saline, i-PRF, and PRF lysate. Methods. An in vitro study was used to determine the minimum inhibitory concentration (MIC) of sutures soaked in saline, i-PRF, and PRF lysate. The sutures were tested against Streptococcus mutans, Prevotella intermedia, and Porphyromonas gingivalis by measuring inhibition zones. Non-absorbable 3-0 black silk sutures were cut and soaked for 10 minutes in saline (group A), i-PRF (group B), or PRF lysate (group C), then incubated anaerobically at 37 \u00b0C for 24 hours. Additionally, samples from all three groups were incubated at 37 \u00b0C in 5 mL of saliva from patients with chronic periodontitis, and colony-forming units (CFUs) were assessed on days 1, 3, 5, and 7. Results. Sutures soaked in i-PRF and PRF lysate demonstrated a statistically significant increase in the zone of inhibition and a reduction in CFU against S. mutans, P. intermedia, and P. gingivalis. Scanning electron microscopy analyses showed a fibrin network on sutures soaked in i-PRF and PRF lysate. Conclusion. The antimicrobial efficacy of i-PRF- and PRF lysate-treated sutures against oral pathogens appears promising. These biologically enhanced sutures may serve as effective alternatives to conventional antimicrobial sutures.<\/jats:p>","DOI":"10.34172\/japid.025.2240","type":"journal-article","created":{"date-parts":[[2025,12,14]],"date-time":"2025-12-14T16:40:03Z","timestamp":1765730403000},"page":"182-187","update-policy":"https:\/\/doi.org\/10.34172\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Evaluation of antimicrobial activity of sutures soaked in injectable platelet rich fibrin or platelet rich fibrin lysate against common oral pathogens: A pilot study"],"prefix":"10.34172","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9330-7858","authenticated-orcid":true,"given":"Megha Hulumanderi","family":"Ravikumar","sequence":"first","affiliation":[{"name":"Department of Periodontology, Bapuji Dental College and Hospital, Davangere, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5197-1785","authenticated-orcid":true,"given":"Raison","family":"Thomas","sequence":"additional","affiliation":[{"name":"Department of Periodontology, Bapuji Dental College and Hospital, Davangere, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8538-8021","authenticated-orcid":true,"given":"Rucha","family":"Shah","sequence":"additional","affiliation":[{"name":"Department of Periodontology, Bapuji Dental College and Hospital, Davangere, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1886-139X","authenticated-orcid":true,"given":"Chandan","family":"Shivamallu","sequence":"additional","affiliation":[{"name":"Department of Biotechnology & Bioinformatics, Jagadguru Sri Shivaratreeshwara Academy of Higher Education & Research, Mysuru, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4790-1941","authenticated-orcid":true,"given":"Chandan","family":"Dharmashekhar","sequence":"additional","affiliation":[{"name":"Department of Life Sciences, JSS Medical College and Hospital, Mysuru, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3207-0137","authenticated-orcid":true,"given":"Triveni Mavinakote","family":"Gowda","sequence":"additional","affiliation":[{"name":"Department of Periodontology, Bapuji Dental College and Hospital, Davangere, India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"20123","published-online":{"date-parts":[[2025,9,15]]},"reference":[{"key":"R1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2005.76.12.2187"},{"key":"R2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051x.1982.tb02099.x"},{"key":"R3","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-198107000-00007"},{"key":"R4","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-196702000-00005"},{"key":"R5","doi-asserted-by":"publisher","DOI":"10.4172\/2161-1122.1000267"},{"key":"R6","doi-asserted-by":"publisher","DOI":"10.1089\/sur.2005.6.313"},{"key":"R7","unstructured":"ToxServices LLC. 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