{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T19:13:34Z","timestamp":1787858014973,"version":"build-2784847793"},"reference-count":0,"publisher":"Maad Rayan Publishing Company","issue":"1","content-domain":{"domain":["japid.tbzmed.ac.ir"],"crossmark-restriction":false},"short-container-title":["J Adv Periodontol Implant Dent"],"abstract":"<jats:p>\n            <jats:bold>Background.<\/jats:bold>  This study aimed to assess the association of haptoglobin (HP) and natural resistance-associated macrophage protein 1 (NRAMP1) alleles with the presence of heme-consuming periodontal pathogens in a group of Iranian patients with chronic periodontitis and peri-implantitis. <jats:bold>Methods.<\/jats:bold>  This cross-sectional study evaluated 69 eligible chronic periodontitis and peri-implantitis patients selected from Shahid Beheshti Dental School. The periodontally diseased individuals had at least three teeth with clinical attachment loss of \u22653 mm and a probing pocket depth (PPD) of \u22653 mm in at least two quadrants. Peri-implant PPD of at least one site was \u22655 mm with or without suppuration and bleeding on probing. A plaque index of &gt;20% and a radiographic crestal bone loss was present in at least one site around the implant. The paper point method was used for sampling from the deepest periodontal\/peri-implant pocket of each tooth or implant for the DNA checkerboard hybridization technique. Statistical analyses were performed with PASW Statistics 18.0. The variables were presented as absolute and relative frequencies (%). <jats:bold>Results.<\/jats:bold>  An Aggregatibacter actinomycetemcomitans (A. actinomycetemcomitans) score of 1\u20132 was 5.8 times more frequent in HP 2, rs1723540 G, and rs2276631 G alleles. A Porphyromonas gingivalis (P. gingivalis) score of 1\u20132 was 4.8 times more common in the subjects carrying HP 2, rs1723540 G, and rs2276631 G alleles compared with HP 1, rs1723540 A, and rs2276631 A alleles. <jats:bold>Conclusion.<\/jats:bold>  Within the limitations of this study, it seems that there was a relationship between HP and NRAMP1 allele frequencies and the presence of heme-consuming periodontal pathogens in the Iranian patients with chronic periodontitis and peri-implantitis evaluated in the present study.<\/jats:p>","DOI":"10.34172\/japid.2020.006","type":"journal-article","created":{"date-parts":[[2020,5,26]],"date-time":"2020-05-26T10:57:58Z","timestamp":1590490678000},"page":"39-44","update-policy":"https:\/\/doi.org\/10.34172\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Association of haptoglobin and natural resistance-associated macrophage protein 1 alleles with heme-consuming periodontal pathogens in chronic periodontitis and peri-implantitis: A pilot study"],"prefix":"10.34172","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6131-2791","authenticated-orcid":true,"given":"Mahdi","family":"Kadkhodazadeh","sequence":"first","affiliation":[{"name":"Dental Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1969-0545","authenticated-orcid":true,"given":"Ahmad Reza","family":"Ebadian","sequence":"additional","affiliation":[{"name":"Private Practice, Tehran, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5480-0247","authenticated-orcid":true,"given":"Zahra","family":"Alizadeh Tabari","sequence":"additional","affiliation":[{"name":"Department of Periodontics, Dental School, Qazvin University of Medical Sciences, Qazvin, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8053-3928","authenticated-orcid":true,"given":"Reza","family":"Amid","sequence":"additional","affiliation":[{"name":"Department of Periodontics, Dental School, Shahid Beheshti University of Medical Sciences, Tehran, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1327-5014","authenticated-orcid":true,"given":"Anahita","family":"Moscowchi","sequence":"additional","affiliation":[{"name":"Department of Periodontics, Dental School, Shahid Beheshti University of Medical Sciences, Tehran, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"20123","published-online":{"date-parts":[[2020,4,25]]},"container-title":["Journal of Advanced Periodontology &amp; Implant Dentistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/japid.tbzmed.ac.ir\/PDF\/japid-12-39.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/japid.tbzmed.ac.ir\/PDF\/japid-12-39.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,26]],"date-time":"2020-05-26T10:57:58Z","timestamp":1590490678000},"score":1,"resource":{"primary":{"URL":"https:\/\/japid.tbzmed.ac.ir\/Article\/japid-1093"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,4,25]]},"references-count":0,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2020,6]]}},"URL":"https:\/\/doi.org\/10.34172\/japid.2020.006","relation":{},"ISSN":["2645-5390"],"issn-type":[{"value":"2645-5390","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,4,25]]},"assertion":[{"value":"Tabriz University of Medical Sciences","name":"journal_owner","label":"Journal Owner"},{"value":"Tabriz University of Medical Sciences","name":"journal_publisher","label":"Journal Publisher"}]}}