{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T02:03:53Z","timestamp":1773108233607,"version":"3.50.1"},"reference-count":0,"publisher":"Maad Rayan Publishing Company","issue":"2","content-domain":{"domain":["japid.tbzmed.ac.ir"],"crossmark-restriction":false},"short-container-title":["J Adv Periodontol Implant Dent"],"published-print":{"date-parts":[[2020,12,10]]},"abstract":"<jats:p>Background. The present study aimed to assess the clinical and radiographic effect of strontium ranelate and metal-substituted hydroxyapatite as bone graft materials on treating chronic periodontitis among diabetes mellitus patients. Methods. A randomized split-mouth study was conducted on 20 sites in 10 controlled type II diabetic patients suffering from chronic periodontitis. After phase I therapy, the sites were randomly allocated by a computer-generated table into two groups. Group 1: A mucoperiosteal flap was elevated in 10 sites, followed by the placement of strontium ranelate mixed with Gengigel. Group 2: A mucoperiosteal flap was elevated in 10 opposite sites, followed by the placement of metal-substituted hydroxyapatite mixed with Gengigel. Clinical parameters were assessed at baseline and 3- and 6-month intervals. Cone-beam computed tomography (CBCT) was used at baseline and after six months to assess bone gain. Results. The two treatment modalities resulted in a statistically significant reduction in clinical parameters at the 3- and 6-month intervals compared to the mean baseline value. Intergroup comparison showed a significant reduction in probing pocket depth and clinical attachment loss in group 1 compared to group 2. Comparison of the two sides by CBCT showed a significant increase in the alveolar bone height in the SR group than the metal-substituted hydroxyapatite group.  Conclusion. Clinical and radiographic results showed a significant improvement in the two groups and provided evidence that strontium ranelate is promising in treating periodontal diseases.<\/jats:p>","DOI":"10.34172\/japid.2020.015","type":"journal-article","created":{"date-parts":[[2021,5,12]],"date-time":"2021-05-12T13:44:25Z","timestamp":1620827065000},"page":"51-57","update-policy":"https:\/\/doi.org\/10.34172\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Clinical and radiographic diagnostic study of strontium ranelate and metal-substituted hydroxyapatite bone graft materials in diabetes mellitus with chronic periodontitis"],"prefix":"10.34172","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6580-7401","authenticated-orcid":true,"given":"Omar","family":"Khashaba","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Atef","family":"Alasfar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6970-3893","authenticated-orcid":true,"given":"Enas Ahmed","family":"Elgendy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bassant","family":"Mowafey","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"20123","published-online":{"date-parts":[[2020,12,10]]},"container-title":["Journal of Advanced Periodontology &amp; Implant Dentistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/japid.tbzmed.ac.ir\/PDF\/japid-12-51.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/japid.tbzmed.ac.ir\/PDF\/japid-12-51.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,5,12]],"date-time":"2021-05-12T13:44:27Z","timestamp":1620827067000},"score":1,"resource":{"primary":{"URL":"https:\/\/japid.tbzmed.ac.ir\/Article\/japid-1121"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,12,10]]},"references-count":0,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2020,12]]}},"URL":"https:\/\/doi.org\/10.34172\/japid.2020.015","relation":{},"ISSN":["2645-5390"],"issn-type":[{"value":"2645-5390","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,12,10]]},"assertion":[{"value":"Tabriz University of Medical Sciences","name":"journal_owner","label":"Journal Owner"},{"value":"Tabriz University of Medical Sciences","name":"journal_publisher","label":"Journal Publisher"},{"value":"2020-10-04","order":1,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-11-15","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-12-10","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}