{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,21]],"date-time":"2026-02-21T08:45:18Z","timestamp":1771663518567,"version":"3.50.1"},"reference-count":27,"publisher":"Maad Rayan Publishing Company","issue":"1","content-domain":{"domain":["japid.tbzmed.ac.ir"],"crossmark-restriction":false},"short-container-title":["J Adv Periodontol Implant Dent"],"abstract":"<jats:p>Background. The current study tested netrin-1 as a reliable inflammatory marker of periodontal disease.  Methods. Gingival crevicular fluid (GCF) samples were taken at baseline from 30 systemically healthy individuals. Fifteen subjects had stage II grade A or B periodontitis, and 15 were periodontally and clinically healthy. Whole-mouth periodontal parameters [probing depth (PD), clinical attachment loss (CAL), plaque index (PI), and gingival index (GI)] were recorded. The GCF samples were re-collected, and clinical parameters were re-recorded after six weeks following full-mouth scaling and root planing (SRP) in the periodontitis group. Results. Netrin-1 GCF levels were significantly lower in periodontitis patients than periodontally healthy individuals at baseline with a significant increase in netrin-1 GCF levels after SRP (P&lt;0.05).  Conclusion. Netrin-1 may have a significant role in the inflammatory process of chronic periodontitis; thus, it could be a promising anti-inflammatory marker in periodontal disease.<\/jats:p>","DOI":"10.34172\/japid.2022.001","type":"journal-article","created":{"date-parts":[[2022,3,28]],"date-time":"2022-03-28T08:13:58Z","timestamp":1648455238000},"page":"1-6","update-policy":"https:\/\/doi.org\/10.34172\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Is netrin-1 a reliable inflammatory marker for periodontitis?"],"prefix":"10.34172","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7184-070X","authenticated-orcid":true,"given":"Sarah Yasser","family":"Abdulfattah","sequence":"first","affiliation":[{"name":"Department of Oral Medicine, Periodontology, Diagnosis and Oral Radiology, Faculty of Dentistry, Mansoura University, Mansoura, Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3700-2547","authenticated-orcid":true,"given":"Azza Abdel Baky","family":"Baiomy","sequence":"additional","affiliation":[{"name":"Department of Clinical Pathology, Faculty of Medicine, Mansoura University, Mansoura, Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0987-8616","authenticated-orcid":true,"given":"Jilan Mohammed","family":"Youssef","sequence":"additional","affiliation":[{"name":"Department of Oral Medicine, Periodontology, Diagnosis and Oral Radiology, Faculty of Dentistry, Mansoura University, Mansoura, Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"20123","published-online":{"date-parts":[[2022,1,24]]},"reference":[{"key":"R1","doi-asserted-by":"publisher","DOI":"10.1186\/s13073-015-0153-3"},{"key":"R2","doi-asserted-by":"crossref","first-page":"2041","DOI":"10.1111\/j.2041-1014.2012.00663.x","article-title":"Beyond the red complex and into more complexity: the polymicrobial synergy and dysbiosis (PSD) model of periodontal disease etiology","volume":"27","author":"Hajishengallis G","year":"2012","journal-title":"Molecular oral microbiology"},{"key":"R3","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2008.080173"},{"key":"R4","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0757.2006.00166.x"},{"key":"R5","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0757.2008.00252.x"},{"key":"R6","doi-asserted-by":"publisher","DOI":"10.1590\/s1678-77572012000200002"},{"key":"R7","first-page":"37","article-title":"Modulating the host response as an adjunctive treatment for periodontitis","volume":"22","author":"Grant-Thomson R","year":"2001","journal-title":"Periodontology"},{"key":"R8","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(94)90420-0"},{"key":"R9","doi-asserted-by":"publisher","DOI":"10.1038\/nm.3467"},{"key":"R10","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/525891"},{"key":"R11","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0506233102"},{"key":"R12","doi-asserted-by":"publisher","DOI":"10.1177\/2048004020959574"},{"key":"R13","doi-asserted-by":"publisher","DOI":"10.1038\/ki.2012.423"},{"key":"R14","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2016.160081"},{"key":"R15","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2011-300012"},{"key":"R16","doi-asserted-by":"publisher","DOI":"10.1007\/s10753-013-9771-3"},{"key":"R17","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.m116.738518"},{"key":"R18","doi-asserted-by":"crossref","first-page":"602","DOI":"10.1902\/jop.1967.38.6_part2.602","article-title":"The periodontal disease index (PDI)","volume":"38","author":"Ramfjord SP","year":"1967","journal-title":"The Journal of Periodontology"},{"key":"R19","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1034\/j.1600-0528.2000.280101.x","article-title":"Analysis strategies for longitudinal attachment loss data","volume":"28","author":"Beck JD","year":"2000","journal-title":"Community Dentistry and Oral Epidemiology"},{"key":"R20","doi-asserted-by":"crossref","first-page":"121","DOI":"10.3109\/00016356408993968","article-title":"Periodontal disease in pregnancy II. 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