{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T16:15:53Z","timestamp":1780676153784,"version":"3.54.1"},"reference-count":0,"publisher":"Maad Rayan Publishing Company","issue":"1","content-domain":{"domain":["japid.tbzmed.ac.ir"],"crossmark-restriction":false},"short-container-title":["J Adv Periodontol Implant Dent"],"abstract":"<jats:p>Background. This study compared human \u03b2-defensin 1 (hBD-1) salivary levels in patients with periodontitis before and after phase I periodontal therapy. Methods. This controlled before-and-after study included 16 patients in the intervention group and 28 participants in the control group. Patients in the intervention group had stage 3 grade B periodontitis with no systemic diseases and had not taken any medications in the last six months. The control group included participants with healthy periodontium. Before and after phase I periodontal therapy, salivary samples were collected from the intervention group. ELISA was used to measure hBD-1 levels. Results. Salivary levels of hBD-1 decreased after phase I periodontal treatment in periodontitis patients, approaching those in healthy individuals. However, this reduction was not statistically significant (P=0.389). In patients with a probing depth (PD) of at least 3 mm, salivary levels of hBD-1 decreased significantly (P=0.019) following the intervention. There was no significant correlation between changes in hBD-1 levels and clinical indices, such as clinical attachment loss (CAL), probing depth, or bleeding index (BI) (P\u02c30.05). Conclusion. The current study demonstrated promising results concerning a probable link between hBD-1 and periodontitis. However, more research with sufficiently large sample sizes and more robust study designs is necessary.<\/jats:p>","DOI":"10.34172\/japid.2024.002","type":"journal-article","created":{"date-parts":[[2024,6,29]],"date-time":"2024-06-29T11:24:10Z","timestamp":1719660250000},"page":"30-35","update-policy":"https:\/\/doi.org\/10.34172\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Comparison of salivary beta-defensin-1 levels in patients with periodontitis before and after phase I periodontal therapy"],"prefix":"10.34172","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6072-7055","authenticated-orcid":true,"given":"Somaye","family":"Ansari Moghadam","sequence":"first","affiliation":[{"name":"Department of Periodontology, Oral and Dental Disease Research Center, Zahedan University of Medical Sciences, Zahedan, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sina","family":"Pishadast","sequence":"additional","affiliation":[{"name":"Oral and Dental Disease Research Center, Zahedan University of Medical Sciences, Zahedan, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leila","family":"Gholami","sequence":"additional","affiliation":[{"name":"Department of Oral Biological and Medical Sciences, Faculty of Dentistry, University of British Columbia, Vancouver, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ebrahim","family":"Alijani","sequence":"additional","affiliation":[{"name":"Department of Clinical Immunology Research Center, Zahedan University of Medical Sciences, Zahedan, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alireza","family":"Ansari Moghadam","sequence":"additional","affiliation":[{"name":"Department of Health Promotion Research Center, Zahedan University of Medical Sciences, Zahedan, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9018-3450","authenticated-orcid":true,"given":"Mahdi","family":"Hadilou","sequence":"additional","affiliation":[{"name":"Faculty of Dentistry, Tabriz University of Medical Sciences, Tabriz, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"20123","published-online":{"date-parts":[[2024,1,29]]},"container-title":["Journal of Advanced Periodontology &amp; Implant Dentistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/japid.tbzmed.ac.ir\/PDF\/japid-16-30.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/japid.tbzmed.ac.ir\/PDF\/japid-16-30.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,29]],"date-time":"2024-06-29T11:24:11Z","timestamp":1719660251000},"score":1,"resource":{"primary":{"URL":"https:\/\/japid.tbzmed.ac.ir\/Article\/japid-2293"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,1,29]]},"references-count":0,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2024,5,28]]}},"URL":"https:\/\/doi.org\/10.34172\/japid.2024.002","relation":{},"ISSN":["2645-5390"],"issn-type":[{"value":"2645-5390","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,1,29]]},"assertion":[{"value":"Tabriz University of Medical Sciences","name":"journal_owner","label":"Journal Owner"},{"value":"Tabriz University of Medical Sciences","name":"journal_publisher","label":"Journal Publisher"},{"value":"2022-12-12","order":1,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-01-18","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-01-29","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}