{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T21:53:03Z","timestamp":1792792383643,"version":"4.5.0"},"reference-count":40,"publisher":"Maad Rayan Publishing Company","issue":"2","content-domain":{"domain":["japid.tbzmed.ac.ir"],"crossmark-restriction":false},"short-container-title":["J Adv Periodontol Implant Dent"],"abstract":"<jats:p>Background. Peri-implant diseases, such as peri-implant mucositis and peri-implantitis, are inflammatory conditions caused by biofilms that can lead to the loss of surrounding soft tissues and bone. The most effective treatment involves non-surgical mechanical debridement to remove plaque, but other treatment modalities have shown limited success. This study investigated the anti-inflammatory and immunomodulatory effects of atorvastatin (ATV) gel as an additional treatment for peri-implant mucositis. Methods. In this double-masked, randomized clinical trial, 49 patients with peri-implant mucositis were randomly divided into two treatment groups: mechanical debridement (MD)+placebo or MD+ATV gel. At baseline, 1 month, and 3 months after the intervention, periodontal parameters, including probing depth (PD), bleeding on probing (BOP), clinical attachment level (CAL), and pain on probing (POP), were measured. Data were analyzed using independent t-test and paired t-test. Results. Statistically significant improvements in CAL and POP were observed from baseline to each time point throughout the study period (P\u22640.001). PD and BOP were statistically significant 1 month and 3 months after the intervention, respectively (P&lt;0.05). Conclusion. The clinical parameters associated with peri-implant mucosal inflammation further improved when ATV gel was used with MD.<\/jats:p>","DOI":"10.34172\/japid.2024.017","type":"journal-article","created":{"date-parts":[[2024,10,22]],"date-time":"2024-10-22T10:57:36Z","timestamp":1729594656000},"page":"116-122","update-policy":"https:\/\/doi.org\/10.34172\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Effect of atorvastatin gel in non-surgical treatment of peri-implant mucositis: A randomized controlled clinical trial"],"prefix":"10.34172","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2232-9117","authenticated-orcid":true,"given":"Azin","family":"Khorramdel","sequence":"first","affiliation":[{"name":"Department of Periodontics, Faculty of Dentistry, Tabriz University of Medical Sciences, Tabriz, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3754-9190","authenticated-orcid":true,"given":"Katayoun","family":"Mogharrab Alile","sequence":"additional","affiliation":[{"name":"Dentist, Faculty of Dentistry, Tabriz Medical Sciences, Islamic Azad University, Tabriz, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5664-9667","authenticated-orcid":true,"given":"Yousef","family":"Kananizadeh","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Tabriz Medical Sciences, Islamic Azad University, Tabriz, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3086-0979","authenticated-orcid":true,"given":"Seyed Amin","family":"Mousavi","sequence":"additional","affiliation":[{"name":"Department of Prosthodontics, Faculty of Dentistry, Tabriz University of Medical Sciences, Tabriz, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4829-2009","authenticated-orcid":true,"given":"Fatima","family":"Molavi","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutics, Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"20123","published-online":{"date-parts":[[2024,9,11]]},"reference":[{"key":"R1","doi-asserted-by":"publisher","DOI":"10.3290\/j.qi.a45428"},{"key":"R2","doi-asserted-by":"publisher","DOI":"10.1016\/j.sdentj.2019.09.008"},{"key":"R3","doi-asserted-by":"publisher","DOI":"10.1007\/s40496-020-00272-4"},{"key":"R4","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.12957"},{"key":"R5","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdsr.2021.05.002"},{"key":"R6","doi-asserted-by":"publisher","DOI":"10.1111\/clr.13397"},{"key":"R7","doi-asserted-by":"publisher","DOI":"10.1111\/prd.12280"},{"key":"R8","doi-asserted-by":"publisher","DOI":"10.1002\/jper.18-0236"},{"key":"R9","doi-asserted-by":"publisher","DOI":"10.3390\/antibiotics9110835"},{"key":"R10","doi-asserted-by":"publisher","DOI":"10.1111\/idj.12490"},{"key":"R11","doi-asserted-by":"publisher","DOI":"10.1016\/j.pdpdt.2019.101587"},{"key":"R12","doi-asserted-by":"publisher","DOI":"10.1007\/s00784-019-03060-2"},{"key":"R13","doi-asserted-by":"publisher","DOI":"10.23736\/s0026-4970.20.04340-x"},{"key":"R14","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.13295"},{"key":"R15","first-page":"123","article-title":"Nonsurgical treatment for peri-implant mucositis: a systematic review and meta-analysis","volume":"13","author":"Barootchi S","year":"2020","journal-title":"Int J Oral Implantol (Berl)"},{"key":"R16","doi-asserted-by":"publisher","DOI":"10.1016\/j.job.2021.06.002"},{"key":"R17","doi-asserted-by":"publisher","DOI":"10.3390\/dj9090100"},{"key":"R18","doi-asserted-by":"publisher","DOI":"10.1111\/jicd.12304"},{"key":"R19","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2016.150706"},{"key":"R20","doi-asserted-by":"publisher","DOI":"10.1111\/clr.12155"},{"key":"R21","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2012.120393"},{"key":"R22","unstructured":"Allen LV Jr, Ansel HC. Parenterals. In: Howes S, ed. Ansel\u2019s Pharmaceutical Dosage Forms and Drug Delivery Systems. 10th ed. Philadelphia: Lippincott Williams & Wilkins; 2013. p. 508-77."},{"key":"R23","unstructured":"Lowe R, Taylor K. Parenteral drug delivery. In: Aulton ME, Taylor K, eds. Aulton\u2019s Pharmaceutics: The Design and Manufacture of Medicines. 4th ed. Elsevier; 2013. p. 623-37."},{"key":"R24","doi-asserted-by":"crossref","unstructured":"Nagarsenkar MS, Dhawan VV. Parenteral preparations. In: Adejare A, ed. Remington: The Science and Practice of Pharmacy. 23rd ed. Academic Press; 2021. p. 577-603. doi: 10.1016\/b978-0-12-820007-0.00029-5.","DOI":"10.1016\/B978-0-12-820007-0.00029-5"},{"key":"R25","doi-asserted-by":"publisher","DOI":"10.4103\/0976-237x.137959"},{"key":"R26","doi-asserted-by":"publisher","DOI":"10.1111\/jre.12514"},{"key":"R27","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdent.2017.08.011"},{"key":"R28","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2015.140503"},{"key":"R29","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2009.01484.x"},{"key":"R30","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2016.130227"},{"key":"R31","doi-asserted-by":"publisher","DOI":"10.1186\/1472-6831-8-16"},{"key":"R32","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2005.76.11.1861"},{"key":"R33","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2006.050140"},{"key":"R34","doi-asserted-by":"publisher","DOI":"10.1111\/fcp.12050"},{"key":"R35","doi-asserted-by":"publisher","DOI":"10.1016\/j.archoralbio.2013.03.002"},{"key":"R36","doi-asserted-by":"publisher","DOI":"10.4103\/0976-500x.162011"},{"key":"R37","doi-asserted-by":"publisher","DOI":"10.1177\/0003319715599863"},{"key":"R38","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2008.070659"},{"key":"R39","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2010.01619.x"},{"key":"R40","doi-asserted-by":"publisher","DOI":"10.1590\/s0103-64402010000300003"}],"container-title":["Journal of Advanced Periodontology &amp; Implant Dentistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/japid.tbzmed.ac.ir\/PDF\/japid-16-116.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/japid.tbzmed.ac.ir\/PDF\/japid-16-116.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,2]],"date-time":"2025-01-02T06:48:15Z","timestamp":1735800495000},"score":1,"resource":{"primary":{"URL":"https:\/\/japid.tbzmed.ac.ir\/Article\/japid-3523"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,9,11]]},"references-count":40,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2024,11,24]]}},"URL":"https:\/\/doi.org\/10.34172\/japid.2024.017","relation":{},"ISSN":["2645-5390"],"issn-type":[{"value":"2645-5390","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,9,11]]},"assertion":[{"value":"Tabriz University of Medical Sciences","name":"journal_owner","label":"Journal Owner"},{"value":"Tabriz University of Medical Sciences","name":"journal_publisher","label":"Journal Publisher"},{"value":"2024-02-20","order":1,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-07-21","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-09-11","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}