{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T15:14:41Z","timestamp":1792595681848,"version":"4.5.0"},"reference-count":49,"publisher":"Maad Rayan Publishing Company","issue":"2","content-domain":{"domain":["japid.tbzmed.ac.ir"],"crossmark-restriction":false},"short-container-title":["J Adv Periodontol Implant Dent"],"abstract":"<jats:p>Background. The vehicle in a local drug delivery (LDD) system plays a vital role in delivering the active drug component at the diseased site. Liquid\/injectable platelet-rich fibrin (i-PRF), an autologous fibrin matrix, might be used as a vehicle to enmesh drugs and deliver locally at the periodontally diseased sites. This study evaluated the efficacy of the drug (ciprofloxacin [Cip])-loaded i-PRF as a LDD system adjunct to subgingival debridement in subjects with periodontal pockets. Methods. In a parallel design study, 79 periodontally diseased pocket sites were randomized to 3 groups: group 1 (n=25), scaling and root planing (SRP)+i-PRF+Cip; group 2 (n=25), SRP+i-PRF; group 3 (n=25), SRP without any adjunctive intervention. Clinical parameters (probing depth [PD], clinical attachment level [CAL], gingival index [GI], plaque index [PI]) and microbial quantification (relative quantification of levels of Aggregatibacter actinomycetemcomitans) were assessed from baseline to 6th and 12th weeks of follow-up. Results. All the treatment groups showed significant improvements in the clinical and microbial parameters assessed. Group 1 showed significantly higher PD and GI reduction with CAL gain and decreased in relative levels of A. actinomycetemcomitans in the 12th week, followed by group 2 compared to group 3. Conclusion. Thus, within the limits of this study, it can be concluded that i-PRF could be considered a potential LDD vehicle for the delivery of ciprofloxacin in periodontal pocket therapy.<\/jats:p>","DOI":"10.34172\/japid.2024.021","type":"journal-article","created":{"date-parts":[[2024,10,22]],"date-time":"2024-10-22T06:57:36Z","timestamp":1729580256000},"page":"94-102","update-policy":"https:\/\/doi.org\/10.34172\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Efficacy of injectable platelet-rich fibrin (i-PRF) as a novel vehicle for local drug delivery in non-surgical periodontal pocket therapy: A randomized controlled clinical trial"],"prefix":"10.34172","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6134-3539","authenticated-orcid":true,"given":"Murugan","family":"Thamaraiselvan","sequence":"first","affiliation":[{"name":"Department of Periodontics, Saveetha Dental College & Hospitals, Saveetha Institute of Medical and Technical Sciences, Chennai, Tamilnadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nadathur Doraisamy","family":"Jayakumar","sequence":"additional","affiliation":[{"name":"Department of Periodontics, Saveetha Dental College & Hospitals, Saveetha Institute of Medical and Technical Sciences, Chennai, Tamilnadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"20123","published-online":{"date-parts":[[2024,9,11]]},"reference":[{"key":"R1","doi-asserted-by":"publisher","DOI":"10.1111\/prd.12119"},{"key":"R2","doi-asserted-by":"publisher","DOI":"10.1111\/prd.12221"},{"key":"R3","doi-asserted-by":"publisher","DOI":"10.1046\/j.0906-6713.2002.03202.x"},{"key":"R4","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2008.01347.x"},{"key":"R5","first-page":"152","article-title":"Factors determining the outcome of scaling and root planing","volume":"26","author":"Zappa UE","year":"1992","journal-title":"Probe"},{"key":"R6","first-page":"74","article-title":"Scaling and root planing: removal of calculus and subgingival organisms","volume":"1","author":"Drisko CL","year":"1991","journal-title":"Curr Opin Dent"},{"key":"R7","first-page":"45","article-title":"The microbiological status of patients with periodontitis in southern Estonia after non-surgical periodontal therapy","volume":"7","author":"L\u00f5ivukene K","year":"2005","journal-title":"Stomatologija"},{"key":"R8","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.13384"},{"key":"R9","doi-asserted-by":"publisher","DOI":"10.1002\/jper.19-0141"},{"key":"R10","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.13232"},{"key":"R11","doi-asserted-by":"publisher","DOI":"10.3390\/dj7040108"},{"key":"R12","doi-asserted-by":"publisher","DOI":"10.1111\/jre.12221"},{"key":"R13","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2006.068001"},{"key":"R14","doi-asserted-by":"publisher","DOI":"10.1186\/s12903-020-01127-1"},{"key":"R15","doi-asserted-by":"publisher","DOI":"10.1034\/j.1601-0825.9.s1.6.x"},{"key":"R16","doi-asserted-by":"publisher","DOI":"10.1007\/s13346-021-01053-x"},{"key":"R17","doi-asserted-by":"publisher","DOI":"10.1590\/1678-7757-2021-0349"},{"key":"R18","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2019.118564"},{"key":"R19","doi-asserted-by":"publisher","DOI":"10.1517\/17425247.2012.665367"},{"key":"R20","doi-asserted-by":"crossref","unstructured":"Miron RJ, Choukroun J. 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